| Line 1: |
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| | __TOC__ | | __TOC__ |
| | + | |
| | + | ==Translocations== |
| | | | |
| | {| class="wikitable" | | {| class="wikitable" |
| | |+Translocations | | |+Translocations |
| | |- | | |- |
| − | |'''Anomaly''' | + | |'''ANOMALY''' |
| − | |'''Associated Disorders''' | + | |'''ASSOCIATED DISORDERS with FISH test''' |
| | + | |'''GENES''' |
| | + | |- |
| | + | |[[der(1)t(1;1)(p36;q21)]] |
| | + | |[[NHL]] |
| | + | |- |
| | + | |[[t(1;3)(p36;q21)]] |
| | + | |[[MDS]],[[ AML]] |
| | + | |[[PRDM16(MEL1)-RPN1]] |
| | + | |- |
| | + | |[[t(1;3;5)(p36;p21;q33) ]] |
| | + | |[[CEL]] |
| | + | |[[WDR48-PDGFRB]] |
| | + | |- |
| | + | |[[t(1;5)(q21;q33)]] |
| | + | |[[MPD]] |
| | + | |[[TPM3-PDGFRB ]] |
| | + | |- |
| | + | |[[t(1;5)(q22;q33)]] |
| | + | |[[MPD with eosinophilia]],[[ CEL]],[[ B-ALL]] |
| | + | |[[PDE4DIP-PDGFRB]] |
| | + | |- |
| | + | |[[der(1;7)(q10;p10)]] |
| | + | |[[MDS]],[[ AML]],[[ MPD]] |
| | + | |- |
| | + | |[[t(1;8)(p13;q24.1)]] |
| | + | |Missing |
| | + | | [[MYC(C-MYC)]] |
| | + | |- |
| | + | |[[t(1;14)(q21;q32) A B C D]] |
| | + | |[[B-ALL]],[[ NHL]] |
| | + | |[[BCL9-IGH]],[[ FCGR2B-IGH]],[[ FCRL4-IGH]],[[ MUC1/IGH]] |
| | + | |- |
| | + | |[[t(1;19)(q23;p13.3) ]] |
| | + | |[[B-ALL]] |
| | + | |[[PBX1-TCF3(E2A)]] |
| | + | |- |
| | + | |[[der(1;22)(q10;p10)]] |
| | + | |- |
| | + | |[[t(2;5)(p23;q35)]] |
| | + | |[[ALCL]],[[ NHL]] |
| | + | |[[ALK-NPM1]] |
| | + | |- |
| | + | |[[t(2;8)(p12;q24.1)]] |
| | + | |[[BL]],[[ B-ALL]],[[ NHL ]] |
| | + | |[[MYC(C-MYC)]] |
| | + | |- |
| | + | |[[t(2;11)(p21;q23)]] |
| | + | |[[MDS]],[[ AML]],[[ B-ALL]] |
| | + | |[[MLL]] |
| | + | |- |
| | + | |[[t(2;14)(p15;q32)]] |
| | + | |[[CLL]],[[ NHL]],[[ B-ALL]],[[ T-ALL]],[[ AML]] |
| | + | |- |
| | + | |[[t(3;3)(q21;q26.2) ]] |
| | + | |[[MDS]],[[ AML]] |
| | + | |[[RPN1-MECOM(EVI1)]] |
| | |- | | |- |
| − | |Bread | + | |[[t(3;5)(p21-25;q32-35)]] |
| − | |Pie | + | |[[MPD]] |
| | + | |[[GOLGA4-PDGFRB ]] |
| | |- | | |- |
| − | |Butter | + | |[[t(3;21)(q26.2;q22) A ]] |
| − | |Ice cream | + | |[[ t-AML]],[[ t-MDS]] |
| | + | |[[RPL22(EAP)-RUNX1(AML1)]] |
| | |- | | |- |
| − | |der(1)t(1;1)(p36;q21) | + | |[[t(4;11)(q21;q23)]] |
| − | |[[NHL]],MDS | + | |[[B-ALL]],[[ T-ALL]] |
| | + | |[[AFF1(AF4)-MLL]] |
| | + | |- |
| | + | |[[t(4;14)(p16.3;q32)]] |
| | + | |[[MM]] |
| | + | |[[ FGFR3-IGH]] |
| | + | |- |
| | + | |[[t(4;22)(q12;q11)]] |
| | + | |[[atypical MPD]] |
| | + | |[[ PDGFRA -BCR]] |
| | + | |- |
| | + | |[[t(4;5;5)(q23;q31;q33)]] |
| | + | |[[chronic basophilic leukemia]] |
| | + | |[[PRKG2-PDGFRB]] |
| | + | |- |
| | + | |[[t(5;7)(q33;q11.2)]] |
| | + | |[[CMML]] |
| | + | |[[HIP1-PDGFRB]] |
| | + | |- |
| | + | |[[t(5;10)(q33;q21)]] |
| | + | |[[atypical MPD]] |
| | + | |[[CCD6-PDGFRB]] |
| | + | |- |
| | + | |[[t(5;12)(q31;p13)]] |
| | + | |[[CEL]],[[ MPD]] |
| | + | |[[ETV6(TEL)-ACSL6 ]] |
| | + | |- |
| | + | |[[t(5;12)(q33;q24)]] |
| | + | |[[MPD with eosinophilia ]] |
| | + | |[[GIT2-PDGFRB]] |
| | + | |- |
| | + | |[[t(5;12)(q33;p13)]] |
| | + | |[[CMML]],[[ MDS]],[[ MPD]] |
| | + | |[[ETV6(TEL)-PDGFRB]] |
| | + | |- |
| | + | |[[t(5;14)(q33;q24)]] |
| | + | |[[MPD]],[[ atypical MPD]] |
| | + | |[[NIN-PDGFRB]] |
| | + | |- |
| | + | |[[t(5;14)(q33;q32)]] |
| | + | |[[CCDC88C(KIAA1509)-PDGFRB]] |
| | + | |- |
| | + | |[[t(5;15)(q33;q22)]] |
| | + | |[[CMML atypical MPD]] |
| | + | |[[TP53BP1-PDGFRB]] |
| | + | |- |
| | + | |[[t(5;14)(q35;q32)]] |
| | + | |[[T-cell lymphoma]] |
| | + | |[[TLX3(HOX11L2)-BCL11B]] |
| | + | |- |
| | + | |[[t(5;16)(q33;q22)]] |
| | + | |[[AML]] |
| | + | |[[CBFB]] |
| | + | |- |
| | + | |[[der(5;17)(p10;q10)]] |
| | + | |[[MDS]],[[ AML]] |
| | + | |[[NPM1(NPM)-RARA]] |
| | + | |- |
| | + | |[[t(5;17)(q33;p11.2)]] |
| | + | |[[JMML ]] |
| | + | |[[SPECC1-PDGFRB]] |
| | + | |- |
| | + | |[[t(5;17)(q33;p13)]] |
| | + | |[[CMML]],[[ atypical MPD]] |
| | + | |[[RABEP1-PDGFRB ]] |
| | + | |- |
| | + | |[[der(6)t(1;6)(q21;p21.3)]] |
| | + | |[[PMF]] |
| | + | |- |
| | + | |[[t(6;9)(p23;q34) ]] |
| | + | |[[MDS]],[[ AML]] |
| | + | |[[DEK-NUP214 (CAN)]] |
| | + | |- |
| | + | |[[t(6;11)(q27;q23) ]] |
| | + | |[[AML]],[[ t-AML]],[[ T-ALL]] |
| | + | |[[MLLT4(AF6)-MLL]] |
| | + | |- |
| | + | |[[t(7;11)(p15;p15)]] |
| | + | |[[AML]] |
| | + | |[[NUP98-HOXA9]] |
| | + | |- |
| | + | |[[t(8;14)(q24.1;q32) ]] |
| | + | |[[BL]],[[ B-ALL]],[[ NHL]] |
| | + | |[[MYC(C-MYC)- IGH]] |
| | + | |- |
| | + | |[[t(8;16)(p11.2;p13.3) A]] |
| | + | |[[AML M4]],[[ M5a]],[[ M5b]],[[ t-MDS]] |
| | + | |[[KAT6A(MYST3)-CREBBP(CBP)]] |
| | + | |- |
| | + | |[[t(8;21)(q22;q22) A ]] |
| | + | |[[AML M2 mostly]],[[ rarely M1]],[[ M4]] |
| | + | |[[RUNX1(AML)-RUNX1T1(ETO)]] |
| | + | |- |
| | + | |[[t(8;22)(q24.1;q11.2) ]] |
| | + | |[[BL]],[[ B-ALL]],[[ NHL]],[[ MM]] |
| | + | |[[MYC(C-MYC)-IGL(IGL)]] |
| | + | |- |
| | + | |[[add(9)(p24)]] |
| | + | |[[JAK2]] |
| | + | |- |
| | + | |[[t(9;11)(p22;q23)]] |
| | + | |[[AML mostly M5]],[[ M4]],[[ B-ALL]] |
| | + | |[[MLLT3(AF9)-MLL]] |
| | + | |- |
| | + | |[[t(9;14)(p13;q32)]] |
| | + | |[[MM]],[[ CLL]],[[ DLBCL]],[[ FL]],[[ MCL splenic MZL]] |
| | + | |[[PAX5-IGH]] |
| | + | |- |
| | + | |[[t(9;22)(q34;q11.2) A B ]] |
| | + | |[[CML]],[[ B-ALL]],[[ T-ALL]] |
| | + | |[[ABL1(ABL)-BCR]] |
| | + | |- |
| | + | |[[t(11;14)(q13;q32) A ]] |
| | + | |[[MCL]],[[ MM]] |
| | + | |[[CCND1(BCL1)- IGH]] |
| | + | |- |
| | + | |[[t(11;14)(q23;q32)]] |
| | + | |[[t-AML]] |
| | + | |[[MLL-KIAA0284]] |
| | + | |- |
| | + | |[[t(11;16)(q23;p13.3)]] |
| | + | |[[t-MDS]],[[ t-AML]] |
| | + | |[[MLL-CREBBP(CBP)]] |
| | + | |- |
| | + | |[[t(11;17)(q23;q21)]] |
| | + | |[[APL]] |
| | + | |[[ZBTB16(PLZF)-RARA]] |
| | + | |- |
| | + | |[[t(11;18)(q21;q21)]] |
| | + | |[[MALT]] |
| | + | |[[BIRC3(API2)-MALT1]] |
| | + | |- |
| | + | |[[t(11;19)(q23;p13.1) ]] |
| | + | |[[AML]] |
| | + | |[[MLL-ELL]] |
| | + | |- |
| | + | |[[t(11;19)(q23;p13.3) ]] |
| | + | |[[B-ALL]],[[ AML]],[[ T-ALL]] |
| | + | |[[MLL-MLLT1(ENL)]] |
| | + | |- |
| | + | |[[t(14;16)(q32;q23)]] |
| | + | |[[MM]] |
| | + | |[[IGH-MAF]] |
| | + | |- |
| | + | |[[t(14;18)(q32;q21) ]] |
| | + | |[[BL]],[[ DLBCL]],[[ FL]],[[ CLL]] |
| | + | |[[IGH-BCL2]] |
| | + | |- |
| | + | |[[t(14;19)(q32;q13.3)]] |
| | + | |[[CLL]],[[ DLBCL]],[[ MCL]],[[ MZL]],[[ SLVL]] |
| | + | |- |
| | + | |[[t(14;22)(q32;q11.2)]] |
| | + | |[[B-ALL]],[[ CLL]],[[ HCL]],[[ AML]],[[ NHL]],[[ DLBCL]] |
| | + | |[[IGH-IGL]] |
| | + | |- |
| | + | |[[t(15;17)(q24;q21)]] |
| | + | |[[APL]] |
| | + | |[[PML-RARA]] |
| | + | |- |
| | + | |[[t(16;16)(p13.1;q22) ]] |
| | + | |[[AML M4Eo]] |
| | + | |[[MYH11-CBFB]] |
| | + | |- |
| | + | |[[der(19)t(1;19)(q23;p13.3)]] |
| | + | |[[B-ALL]],[[ L3-like ALL]],[[ T-ALL]],[[ NHL]],[[ AML]] |
| | + | |[[PBX1-TCF3(E2A)]] |
| | + | |- |
| | + | |[[der(Y)t(Y;1)(q12;q12) ]] |
| | + | |[[MDS]] |
| | | | |
| | |} | | |} |
| | | | |
| − | ==Myelodysplastic Syndromes (MDS)==
| |
| | | | |
| − | : [[+11 or trisomy 11 (solely) KMT2A]]
| + | ==Inversions== |
| − | : [[+13 or trisomy 13]]
| |
| − | : [[+14 or trisomy 14 (solely)]]
| |
| − | : [[+15 or trisomy 15 (as sole autosomal abnormality)]]
| |
| − | : [[+16 or trisomy 16 (solely)]]
| |
| − | : [[+18 or trisomy 18 in lymphoproliferative disorders]]
| |
| − | : [[+20 or trisomy 20 (solely)]]
| |
| − | : [[+21 or trisomy 21]]
| |
| − | : [[+6 or trisomy 6]]
| |
| − | : [[+7 or trisomy 7 (solely)]]
| |
| − | : [[+8 or trisomy 8]]
| |
| − | : [[+9 or trisomy 9]]
| |
| − | : [[-21 or monosomy 21 (solely)]]
| |
| − | : [[-7/del(7q) in adults]]
| |
| − | : [[-7/del(7q) in childhood]]
| |
| − | : [[11q23 rearrangements (KMT2A) in leukaemia]]
| |
| − | : [[12p abnormalities in myeloid malignancies]]
| |
| − | : [[1q translocations (unbalanced) in myeloid malignancies]]
| |
| − | : [[1q triplication in hematologic malignancies]]
| |
| − | : [[3q26 rearrangements (MECOM) in myeloid malignancies]]
| |
| − | : [[Atypical Chronic Myeloid Leukemia (aCML)]]
| |
| − | : [[Childhood myelodysplastic syndromes]]
| |
| − | : [[Classification of myelodysplasic syndromes]]
| |
| − | : [[Congenital leukaemias]]
| |
| − | : [[Infant leukaemias]]
| |
| − | : [[Isolated tetrasomy 8 in AML, MDS and MPD]]
| |
| − | : [[MLL amplification in leukemia]]
| |
| − | : [[Monosomal karyotype (MK) in myeloid malignancies]]
| |
| − | : [[Neonatal leukaemias]]
| |
| − | : [[Refractory anemia (RA)]]
| |
| − | : [[Refractory anemia with excess blasts (RAEB)]]
| |
| − | : [[Refractory anemia with ringed sideroblasts (RARS)]]
| |
| − | : [[Trisomy 19]]
| |
| − | : [[Trisomy 2]]
| |
| − | : [[Y loss in leukemia]]
| |
| − | : [[del (3q)]]
| |
| − | : [[del (13q)]]
| |
| − | : [[del(13q) in myeloid malignancies]]
| |
| − | : [[del(16)(q22) CBFB/MYH11]]
| |
| − | : [[del(17p) in myeloid malignancies]]
| |
| − | : [[del(20q) in myeloid malignancies]]
| |
| − | : [[del(21)(q21q22) USP16/RUNX1]]
| |
| − | : [[del(5q) in myeloid neoplasms]]
| |
| − | : [[del(9q) solely]]
| |
| − | : [[dic(17;20)(p11.2;q11.2)]]
| |
| − | : [[dic(1;15)(p11;p11)]]
| |
| − | : [[i(17q) solely in myeloid malignancies]]
| |
| − | : [[i(5)(p10) in acute myeloid leukemia]]
| |
| − | : [[ider(20q) in Myeloid Malignancies]]
| |
| − | : [[idic(X)(q13)]]
| |
| − | : [[ins(3;3)(q26;q21q26) PSMD2/MECOM]]
| |
| − | : [[inv(11)(p15q22) NUP98/DDX10]]
| |
| − | : [[inv(11)(q21q23) KMT2A/MAML2 in therapy related leukemias]]
| |
| − | : [[inv(12)(p13q15) ETV6/PTPRR]]
| |
| − | : [[inv(16)(p13q22) CBFB/MYH11]]
| |
| − | : [[inv(18)(p11q21)]]
| |
| − | : [[inv(3)(q21q26) PSMD2/MECOM]]
| |
| − | : [[inv(6)(p15q13)]]
| |
| − | : [[inv(6)(p25q13)]]
| |
| − | : [[t(10;12)(q24;p13) ETV6/GOT1]]
| |
| − | : [[t(10;16)(q22;p13) KAT6B/CREBBP]]
| |
| − | : [[t(11;11)(p15;q22) NUP98/DDX10]]
| |
| − | : [[t(11;14)(p15;q22) AP2A2/NID2]]
| |
| − | : [[t(11;16)(q23;p13.3) KMT2A/CREBBP]]
| |
| − | : [[t(11;17)(q23;q25) KMT2A/SEPT9]]
| |
| − | : [[t(11;20)(p15;q11) NUP98/TOP1]]
| |
| − | : [[t(11;21)(q13;q22) RUNX1/MACROD1]]
| |
| − | : [[t(12;12)(p13;q13) ETV6/BAZ2A]]
| |
| − | : [[t(12;12)(p13;q13) HMGA2/?]]
| |
| − | : [[t(12;13)(p12;q12-14) ETV6/CDX2]]
| |
| − | : [[t(12;13)(p13;q14) LIN00598/ETV6]]
| |
| − | : [[t(12;14)(q13;q31) HMGA2/?]]
| |
| − | : [[t(12;17)(p13;p13) ETV6/PER1]]
| |
| − | : [[t(12;18)(p13;q12) ETV6/SETBP1]]
| |
| − | : [[t(12;20)(q15;q11.2) HMGA2 truncated]]
| |
| − | : [[t(12;22)(p13;q12) MN1/ETV6]]
| |
| − | : [[t(14;21)(q22;q22) RUNX1/?]]
| |
| − | : [[t(15;21)(q22;q22) RUNX1/?]]
| |
| − | : [[t(16;16)(p13;q22) CBFB/MYH11]]
| |
| − | : [[t(16;21)(q24;q22) RUNX1/CBFA2T3]]
| |
| − | : [[t(1;11)(p32;q23) KMT2A/EPS15]]
| |
| − | : [[t(1;12)(p36;p13) ETV6/MDS2]]
| |
| − | : [[t(1;12)(q21;p13) ETV6/ARNT]]
| |
| − | : [[t(1;12)(q21;q24)]]
| |
| − | : [[t(1;16)(q11;q11)]]
| |
| − | : [[t(1;18)(q10;q10)]]
| |
| − | : [[t(1;19)(p13;p13.1)]]
| |
| − | : [[t(1;2)(p36;p21) PRDM16 and LINC00982/?]]
| |
| − | : [[t(1;21)(p36;q22) RUNX1/PRDM16]]
| |
| − | : [[t(1;3)(p36;p21)]]
| |
| − | : [[t(1;3)(p36;q21) PSMD2/PRDM16]]
| |
| − | : [[t(1;6)(p36;p21)]]
| |
| − | : [[t(1;7)(q10;p10)]]
| |
| − | : [[t(20;21)(q13.2;q22.12) ZFP64/RUNX1]]
| |
| − | : [[t(20;21)(q13;q22) RUNX1/?]]
| |
| − | : [[t(2;11)(p21;q23) KMT2A/?]]
| |
| − | : [[t(2;11)(q31;p15) NUP98/HOXD11]]
| |
| − | : [[t(2;11)(q31;p15) NUP98/HOXD13]]
| |
| − | : [[t(2;12)(q31;p13) ETV6/?]]
| |
| − | : [[t(2;3)(p15-23;q26-27) ?/MECOM]]
| |
| − | : [[t(2;3)(p15-23;q26-27) ?/MECOM]]
| |
| − | : [[t(2;4)(p23;q25-q35)]]
| |
| − | : [[t(3;11)(p25;p15) ANKRD28/NUP98]]
| |
| − | : [[t(3;11)(q12;p15) NUP98/LNP1]]
| |
| − | : [[t(3;12)(q26;p13) ETV6/EVI1]]
| |
| − | : [[t(3;12)(q26;p13) ETV6/MECOM]]
| |
| − | : [[t(3;16)(q21;q22)]]
| |
| − | : [[t(3;18)(q26;q11) ?/MECOM]]
| |
| − | : [[t(3;21)(q26;q22) RUNX1/MECOM]]
| |
| − | : [[t(3;3)(p24;q26) ?/MECOM]]
| |
| − | : [[t(3;3)(q21;q26) PSMD2/MECOM]]
| |
| − | : [[t(3;4)(p21;q34)]]
| |
| − | : [[t(3;5)(q21;q31)]]
| |
| − | : [[t(3;5)(q25;q34) NPM1/MLF1]]
| |
| − | : [[t(3;8)(q26;q24) PVT1/MECOM]]
| |
| − | : [[t(4;11)(p12;q23) KMT2A/FRYL]]
| |
| − | : [[t(4;5)(q31;q31)]]
| |
| − | : [[t(5;11)(q31;q23) KMT2A/ARHGAP26]]
| |
| − | : [[t(5;12)(q13;p13) ?/ETV6]]
| |
| − | : [[t(5;12)(q31;p13) ETV6/ACSL6 in MDS,AML and AEL]]
| |
| − | : [[t(5;12)(q33;p13) ETV6/PDGFRB]]
| |
| − | : [[t(5;16)(q32;p13) NDE1/PDGFRB]]
| |
| − | : [[t(5;17)(q33;p11.2) SPECC1/PDGFRB]]
| |
| − | : [[t(5;17)(q33;p13) RABEP1/PDGFRB]]
| |
| − | : [[t(5;21)(q13;q22) RUNX1/?]]
| |
| − | : [[t(5;7)(q33;q11) HIP1/PDGFRB]]
| |
| − | : [[t(6;12)(p21;p13) CCND3/ETV6 in lymphoid malignancies]]
| |
| − | : [[t(6;20)(q13;q12) LMBRD1/CHD6]]
| |
| − | : [[t(6;21)(p22;q22) RUNX1-?]]
| |
| − | : [[t(6;8)(q27;p12) FGFR1OP/FGFR1]]
| |
| − | : [[t(6;9)(p22;q34) DEK/NUP214]]
| |
| − | : [[t(7;12)(p12;q13) HMGA2 truncated]]
| |
| − | : [[t(7;12)(q36;p13) MNX1/ETV6]]
| |
| − | : [[t(8;12)(q12;p13)]]
| |
| − | : [[t(8;12)(q22;q13) HMGA2/?]]
| |
| − | : [[t(8;13)(p11;q12) ZMYM2/FGFR1]]
| |
| − | : [[t(8;21)(q23;q22) RUNX1/ZFPM2]]
| |
| − | : [[t(8;9)(p22;p24) PCM1/JAK2]]
| |
| − | : [[t(9;12)(p24;p13) ETV6/JAK2]]
| |
| − | : [[t(9;12)(q22;p12) ETV6/SYK]]
| |
| − | : [[t(9;12)(q34;p13) ETV6/ABL1]]
| |
| − | : [[t(X;20)(q13;q13.3)]]
| |
| − | : [[t(Y;1)(q12;q12)]]
| |
| | | | |
| − | ==Treatment Related Leukaemias (t-ANLL)== | + | {| class="wikitable" |
| | + | |+INVERSIONS |
| | + | |- |
| | + | |'''ANOMALY''' |
| | + | |'''ASSOCIATED DISORDERS with FISH test''' |
| | + | |'''GENES''' |
| | + | |- |
| | + | |[[inv(3)(q21q26.2) ]] |
| | + | |[[MDS]],[[ AML]] |
| | + | |[[RPN1-MECOM(EVI1)]] |
| | + | |- |
| | + | |[[inv(11)(q21q23) ]] |
| | + | |[[MDS]],[[ AML M2]],[[ T-ALL]] |
| | + | |[[MAML2-MLL]] |
| | + | |- |
| | + | |[[inv(14)(q11.2q32) ]] |
| | + | |[[PLL]] |
| | + | |[[TRA-TCL1A(TCL1)]] |
| | + | |- |
| | + | |[[inv(16)(p13.1q22)]] |
| | + | |[[AML M4Eo]] |
| | + | |[[MYH11]],[[ CBFB]] |
| | + | |} |
| | | | |
| − | : [[+11 or trisomy 11 (solely) KMT2A]]
| + | ==Duplications== |
| − | : [[+20 or trisomy 20 (solely)]]
| |
| − | : [[+4 or trisomy 4]]
| |
| − | : [[+8 or trisomy 8]]
| |
| − | : [[-7/del(7q) in adults]]
| |
| − | : [[-7/del(7q) in childhood]]
| |
| − | : [[11p15 rearrangements (NUP98) in treatment related leukemia]]
| |
| − | : [[11q23 rearrangements (KMT2A) in leukaemia]]
| |
| − | : [[11q23 rearrangements (KMT2A) in therapy related leukaemias]]
| |
| − | : [[12p abnormalities in myeloid malignancies]]
| |
| − | : [[12p13 rearrangements (ETV6) in treatment related leukemia]]
| |
| − | : [[21q22 rearrangements (RUNX1) in treatment related leukemia]]
| |
| − | : [[3q21q26 rearrangements (RPN1/MECOM) in treatment related leukemia]]
| |
| − | : [[Biphenotypic Acute Leukaemia (BAL)]]
| |
| − | : [[Childhood myelodysplastic syndromes]]
| |
| − | : [[Classification of acute myeloid leukemias]]
| |
| − | : [[Classification of myelodysplasic syndromes]]
| |
| − | : [[MLL amplification in leukemia]]
| |
| − | : [[del(13q) in myeloid malignancies]]
| |
| − | : [[del(16)(q22) CBFB/MYH11]]
| |
| − | : [[del(17p) in myeloid malignancies]]
| |
| − | : [[del(5q) in myeloid neoplasms]]
| |
| − | : [[dic(17;20)(p11.2;q11.2)]]
| |
| − | : [[inv(11)(q21q23) KMT2A/MAML2 in therapy related leukemias]]
| |
| − | : [[inv(16)(p13q22) CBFB/MYH11]]
| |
| − | : [[inv(16)(p13q22) CBFB/MYH11 in treatment related leukemia]]
| |
| − | : [[inv(6)(p15q13)]]
| |
| − | : [[t(10;11)(p12;q23) KMT2A/MLLT10]]
| |
| − | : [[t(11;11)(q13;q23) KMT2A/ARHGEF17]]
| |
| − | : [[t(11;12)(p15;q13) NUP98/?]]
| |
| − | : [[t(11;12)(q23;q13) /HMGA2]]
| |
| − | : [[t(11;14)(q23;q32) KMT2A/CEP170B]]
| |
| − | : [[t(11;15)(q23;q14) KMT2A/CASC5]]
| |
| − | : [[t(11;16)(q23;p13.3) KMT2A/CREBBP]]
| |
| − | : [[t(11;17)(q23;p13) KMT2A/GAS7]]
| |
| − | : [[t(11;17)(q23;q25) KMT2A/SEPT9]]
| |
| − | : [[t(11;19)(q23;p13.1) KMT2A/ELL]]
| |
| − | : [[t(11;19)(q23;p13.3) KMT2A/MLLT1]]
| |
| − | : [[t(11;20)(p15;q11) NUP98/TOP1]]
| |
| − | : [[t(11;22)(q23;q13) KMT2A/EP300]]
| |
| − | : [[t(12;13)(p13;q14) LIN00598/ETV6]]
| |
| − | : [[t(12;21)(q24;q22) RUNX1/?]]
| |
| − | : [[t(14;21)(q22;q22) RUNX1/?]]
| |
| − | : [[t(15;17)(q22;q21) in treatment related leukemia]]
| |
| − | : [[t(15;17)(q24;q21) PML/RARA]]
| |
| − | : [[t(15;21)(q22;q22) RUNX1/?]]
| |
| − | : [[t(16;16)(p13;q22) CBFB/MYH11]]
| |
| − | : [[t(16;21)(q24;q22) RUNX1/CBFA2T3]]
| |
| − | : [[t(17;21)(q11.2;q22) RUNX1/?]]
| |
| − | : [[t(18;21)(q21;q22) RUNX1/?]]
| |
| − | : [[t(19;21)(q13.4;q22) RUNX1 truncated]]
| |
| − | : [[t(1;11)(q23;p15) NUP98/PRRX1]]
| |
| − | : [[t(1;12)(q21;q24)]]
| |
| − | : [[t(1;21)(p22;q22) RUNX1/CLCA2]]
| |
| − | : [[t(1;21)(p36;q22) RUNX1/PRDM16]]
| |
| − | : [[t(1;3)(p36;p21)]]
| |
| − | : [[t(1;3)(p36;q21) PSMD2/PRDM16]]
| |
| − | : [[t(1;6)(p36;p21)]]
| |
| − | : [[t(1;7)(p36;q34)]]
| |
| − | : [[t(1;7)(q10;p10)]]
| |
| − | : [[t(2;11)(q31;p15) NUP98/HOXD11]]
| |
| − | : [[t(2;11)(q31;p15) NUP98/HOXD13]]
| |
| − | : [[t(2;11)(q37;q23) KMT2A/SEPT2]]
| |
| − | : [[t(2;19)(p11;p13)]]
| |
| − | : [[t(2;3)(p15-23;q26-27) ?/MECOM]]
| |
| − | : [[t(2;3)(p15-23;q26-27) ?/MECOM]]
| |
| − | : [[t(2;8)(p23;p11) KAT6A/ASXL2]]
| |
| − | : [[t(3;11)(p21;q23) KMT2A/NCKIPSD]]
| |
| − | : [[t(3;11)(q25;q23) KMT2A/GMPS]]
| |
| − | : [[t(3;11)(q28;q23) KMT2A/LPP]]
| |
| − | : [[t(3;12)(q26;q21) ?/MECOM]]
| |
| − | : [[t(3;17)(q26;q22) ?/MECOM]]
| |
| − | : [[t(3;21)(q26;q22) RUNX1/MECOM]]
| |
| − | : [[t(3;21)(q26;q22) RUNX1/MECOM in treatment related leukemia]]
| |
| − | : [[t(3;6)(q25;q26) ?/MECOM]]
| |
| − | : [[t(4;11)(p12;q23) KMT2A/FRYL]]
| |
| − | : [[t(4;11)(q21;q23) KMT2A/AFF1]]
| |
| − | : [[t(4;12)(q12;p13) CHIC2/ETV6]]
| |
| − | : [[t(5;11)(q31;q23) KMT2A/ARHGAP26]]
| |
| − | : [[t(6;11)(q27;q23) KMT2A/MLLT4]]
| |
| − | : [[t(6;21)(p22;q22) RUNX1-?]]
| |
| − | : [[t(6;9)(p22;q34) DEK/NUP214]]
| |
| − | : [[t(8;16)(p11;p13) KAT6A/CREBBP]]
| |
| − | : [[t(8;16)(p11;p13) KAT6A/CREBBP in treatment related leukemia]]
| |
| − | : [[t(8;21)(q22;q22) RUNX1/RUNX1T1]]
| |
| − | : [[t(8;21)(q22;q22) RUNX1/RUNX1T1 in treatment related leukemia]]
| |
| − | : [[t(9;11)(p22;q23) KMT2A/MLLT3]]
| |
| − | : [[t(9;21)(p22;q22)]]
| |
| − | : [[t(9;22)(q34;q11) BCR/ABL1 in treatment related leukemia]]
| |
| | | | |
| − | ==Acute Non Lymphocytic Leukaemias (ANLL)== | + | {| class="wikitable" |
| | + | |+DUPLICATIONS |
| | + | |- |
| | + | |'''ANOMALY''' |
| | + | |'''ASSOCIATED DISORDERS with FISH test''' |
| | + | |'''GENES''' |
| | + | |- |
| | + | |[[dup(1)(q11q44) ]] |
| | + | |- |
| | + | |[[dup(1)(q21q32) ]] |
| | + | |[[B-ALL]],[[ NHL]] |
| | + | |- |
| | + | |[[dup(1)(q21q42)]] |
| | + | |- |
| | + | |[[dup(1)(q23q32)]] |
| | + | |- |
| | + | |[[dup(1)(q23q42)]] |
| | + | |[[NHL ]] |
| | + | |- |
| | + | |[[dup(11)(q13q25)]] |
| | + | |[[NHL ]] |
| | + | |[[MLL]] |
| | + | |- |
| | + | |[[dup(12)(q13q22)]] |
| | + | |} |
| | | | |
| − | : [[+10 or trisomy 10 (solely)]]
| |
| − | : [[+11 or trisomy 11 (solely) KMT2A]]
| |
| − | : [[+13 or trisomy 13]]
| |
| − | : [[+13,+13 or tetrasomy 13]]
| |
| − | : [[+14 or trisomy 14 (solely)]]
| |
| − | : [[+15 or trisomy 15 (as sole autosomal abnormality)]]
| |
| − | : [[+16 or trisomy 16 (solely)]]
| |
| − | : [[+18 or trisomy 18 in lymphoproliferative disorders]]
| |
| − | : [[+21 or trisomy 21]]
| |
| − | : [[+22 or trisomy 22 (solely?)]]
| |
| − | : [[+4 or trisomy 4]]
| |
| − | : [[+6 or trisomy 6]]
| |
| − | : [[+7 or trisomy 7 (solely)]]
| |
| − | : [[+8 or trisomy 8]]
| |
| − | : [[+9 or trisomy 9]]
| |
| − | : [[-21 or monosomy 21 (solely)]]
| |
| − | : [[-7/del(7q) in adults]]
| |
| − | : [[-7/del(7q) in childhood]]
| |
| − | : [[11q23 rearrangements (KMT2A) in de novo childhood acute myeloid leukemia]]
| |
| − | : [[11q23 rearrangements (KMT2A) in leukaemia]]
| |
| − | : [[12p abnormalities in myeloid malignancies]]
| |
| − | : [[15q13-15 Rearrangements]]
| |
| − | : [[1q translocations (unbalanced) in myeloid malignancies]]
| |
| − | : [[1q triplication in hematologic malignancies]]
| |
| − | : [[3q26 rearrangements (MECOM) in myeloid malignancies]]
| |
| − | : [[Acute Erythroid leukaemias]]
| |
| − | : [[Acute basophilic leukemia]]
| |
| − | : [[Acute megakaryoblastic leukemia (AMegL)]]
| |
| − | : [[Acute promyelocytic leukemia (APL)]]
| |
| − | : [[Biphenotypic Acute Leukaemia (BAL)]]
| |
| − | : [[Classification of acute myeloid leukemias]]
| |
| − | : [[Congenital leukaemias]]
| |
| − | : [[Infant leukaemias]]
| |
| − | : [[Isolated tetrasomy 8 in AML, MDS and MPD]]
| |
| − | : [[M0 acute non lymphocytic leukemia (M0-ANLL)]]
| |
| − | : [[M3/M3v acute myeloid leukemia (AML M3/M3v)]]
| |
| − | : [[M3/M3v acute non lymphocytic leukemia (M3-ANLL)]]
| |
| − | : [[M7 acute non lymphocytic leukemia (M7-ANLL)]]
| |
| − | : [[MLL amplification in leukemia]]
| |
| − | : [[Monosomal karyotype (MK) in myeloid malignancies]]
| |
| − | : [[Neonatal leukaemias]]
| |
| − | : [[Systemic mast cell disease (SMCD)]]
| |
| − | : [[Trisomy 19]]
| |
| − | : [[Trisomy 2]]
| |
| − | : [[Trisomy 5]]
| |
| − | : [[Y loss in leukemia]]
| |
| − | : [[del (13q)]]
| |
| − | : [[del(11)(q23q23) KMT2A/ARHGEF12]]
| |
| − | : [[del(11)(q23q23) KMT2A/CBL]]
| |
| − | : [[del(16)(q22) CBFB/MYH11]]
| |
| − | : [[del(17)(q21q24) PRKAR1A/RARA]]
| |
| − | : [[del(17p) in myeloid malignancies]]
| |
| − | : [[del(20q) in myeloid malignancies]]
| |
| − | : [[del(21)(q21q22) USP16/RUNX1]]
| |
| − | : [[del(4)(q12q12) FIP1L1/PDGFRA]]
| |
| − | : [[del(5q) in myeloid neoplasms]]
| |
| − | : [[del(9q) solely]]
| |
| − | : [[dic(17;20)(p11.2;q11.2)]]
| |
| − | : [[dic(1;15)(p11;p11)]]
| |
| − | : [[dup(17)(q12q21) STAT5B/RARA]]
| |
| − | : [[i(5)(p10) in acute myeloid leukemia]]
| |
| − | : [[i(8)(q10) in acute myeloid leukaemia]]
| |
| − | : [[ider(20q) in Myeloid Malignancies]]
| |
| − | : [[idic(7)(q11.2)]]
| |
| − | : [[idic(X)(q13)]]
| |
| − | : [[ins(3;3)(q26;q21q26) PSMD2/MECOM]]
| |
| − | : [[ins(X;11)(q26;q23q23)]]
| |
| − | : [[inv(11)(p15q22) NUP98/DDX10]]
| |
| − | : [[inv(12)(p13q15) ETV6/PTPRR]]
| |
| − | : [[inv(14)(q11q32.1) TRA-TRD/TCL1A]]
| |
| − | : [[inv(16)(p13q22) CBFB/MYH11]]
| |
| − | : [[inv(16)(p13q24) CBFA2T3/GLIS2]]
| |
| − | : [[inv(2)(p23q13) RANBP2/ALK]]
| |
| − | : [[inv(3)(q21q26) PSMD2/MECOM]]
| |
| − | : [[inv(3)(q21q26) PSMD2/MECOM]]
| |
| − | : [[inv(6)(p25q13)]]
| |
| − | : [[inv(8)(p11q13) KAT6A/NCOA2]]
| |
| − | : [[t(10;11)(p11.2;q23) KMT2A/ABI1]]
| |
| − | : [[t(10;11)(p12;q23) KMT2A/MLLT10]]
| |
| − | : [[t(10;11)(p12;q23) KMT2A/NEBL]]
| |
| − | : [[t(10;11)(p13;q21) PICALM/MLLT10]]
| |
| − | : [[t(10;11)(q22;q23) KMT2A/TET1]]
| |
| − | : [[t(10;16)(q22;p13) KAT6B/CREBBP]]
| |
| − | : [[t(10;17)(p15;q21) ZMYND11/MBTD1]]
| |
| − | : [[t(11;11)(p15;q22) NUP98/DDX10]]
| |
| − | : [[t(11;11)(q23;q23) KMT2A/CBL]]
| |
| − | : [[t(11;12)(p15;p13) NUP98/KDM5A]]
| |
| − | : [[t(11;12)(q23;q13) KMT2A/SARNP]]
| |
| − | : [[t(11;16)(q23;p13.3) KMT2A/CREBBP]]
| |
| − | : [[t(11;17)(p15;p13) NUP98/PHF23]]
| |
| − | : [[t(11;17)(q13;q21) NUMA1/RARA]]
| |
| − | : [[t(11;17)(q23;p13) KMT2A/GAS7]]
| |
| − | : [[t(11;17)(q23;q12) KMT2A/RARA]]
| |
| − | : [[t(11;17)(q23;q12-21) KMT2A/LASP1]]
| |
| − | : [[t(11;17)(q23;q12-21) KMT2A/MMLT6]]
| |
| − | : [[t(11;17)(q23;q21) ZBTB16/RARA]]
| |
| − | : [[t(11;17)(q23;q25) KMT2A/SEPT9]]
| |
| − | : [[t(11;19)(q23;p13) KMT2A/SH3GL1]]
| |
| − | : [[t(11;19)(q23;p13.1) KMT2A/ELL]]
| |
| − | : [[t(11;19)(q23;p13.3) KMT2A/MLLT1]]
| |
| − | : [[t(11;20)(p15;q11) NUP98/TOP1]]
| |
| − | : [[t(11;21)(p14;q22) RUNX1/KIAA1549L]]
| |
| − | : [[t(11;21)(q13;q22) RUNX1/MACROD1]]
| |
| − | : [[t(11;21)(q21;q22) RUNX1/LPXN]]
| |
| − | : [[t(11;22)(q23;q11.2) KMT2A/SEPT5]]
| |
| − | : [[t(12;12)(p13;q13) ETV6/BAZ2A]]
| |
| − | : [[t(12;13)(p12;q12-14) ETV6/CDX2]]
| |
| − | : [[t(12;13)(p13;q14) LIN00598/ETV6]]
| |
| − | : [[t(12;15)(p13;q25) ETV6/NTRK3]]
| |
| − | : [[t(12;17)(p11;q11) in AML]]
| |
| − | : [[t(12;17)(p13;p13) ETV6/PER1]]
| |
| − | : [[t(12;17)(p13;q11) TAF15/ZNF384]]
| |
| − | : [[t(12;18)(p13;q12) ETV6/SETBP1]]
| |
| − | : [[t(12;19)(q13;q13)]]
| |
| − | : [[t(12;21)(q12;q22) RUNX1 truncated]]
| |
| − | : [[t(12;22)(p13;q12) EWSR1/ZNF384]]
| |
| − | : [[t(12;22)(p13;q12) MN1/ETV6]]
| |
| − | : [[t(14;14)(q11;q32.1) TRA-TRD/TCL1A]]
| |
| − | : [[t(14;22)(q32;q11) IGH/IGL]]
| |
| − | : [[t(15;17)(q24;q21) PML/RARA]]
| |
| − | : [[t(16;16)(p13;q22) CBFB/MYH11]]
| |
| − | : [[t(16;21)(p11;q22) FUS/ERG]]
| |
| − | : [[t(16;21)(q24;q22) RUNX1/CBFA2T3]]
| |
| − | : [[t(17;17)(q21;q21) STAT5B/RARA]]
| |
| − | : [[t(17;17)(q21;q24) PRKAR1A/RARA]]
| |
| − | : [[t(17;21)(q11.2;q22) RUNX1/?]]
| |
| − | : [[t(1;11)(p32;q23) KMT2A/EPS15]]
| |
| − | : [[t(1;11)(q21;q23) KMT2A/MLLT11]]
| |
| − | : [[t(1;12)(q21;q24)]]
| |
| − | : [[t(1;12)(q25;p13) ETV6/ABL2]]
| |
| − | : [[t(1;14)(q25;q32) IGH/LHX4]]
| |
| − | : [[t(1;16)(q12;q24)]]
| |
| − | : [[t(1;18)(q25;q23)]]
| |
| − | : [[t(1;19)(p13;p13.1)]]
| |
| − | : [[t(1;19)(q23;p13) TCF3/PBX1]]
| |
| − | : [[t(1;2)(q12;q37)]]
| |
| − | : [[t(1;21)(p32;q22) RUNX1/?]]
| |
| − | : [[t(1;21)(p35;q22) RUNX1/YTHDF2]]
| |
| − | : [[t(1;21)(p36;q22) RUNX1/PRDM16]]
| |
| − | : [[t(1;21)(q12;q22) RUNX1/?]]
| |
| − | : [[t(1;21)(q21;q22) RUNX1/ZNF687]]
| |
| − | : [[t(1;22)(p13;q13) RBM15/MKL1]]
| |
| − | : [[t(1;3)(p36;p21)]]
| |
| − | : [[t(1;3)(p36;q21) PSMD2/PRDM16]]
| |
| − | : [[t(1;7)(p36;q34)]]
| |
| − | : [[t(1;7)(q10;p10)]]
| |
| − | : [[t(1;8)(p22-p32;q22-q23)]]
| |
| − | : [[t(20;21)(q11;q22) RUNX1/?]]
| |
| − | : [[t(20;21)(q13;q22) RUNX1/?]]
| |
| − | : [[t(2;11)(p21;q23) KMT2A/?]]
| |
| − | : [[t(2;11)(q31;p15) NUP98/HOXD11]]
| |
| − | : [[t(2;11)(q31;p15) NUP98/HOXD13]]
| |
| − | : [[t(2;11)(q37;q23) KMT2A/SEPT2]]
| |
| − | : [[t(2;14)(p13-16;q32) IGH/BCL11A]]
| |
| − | : [[t(2;19)(p11;p13)]]
| |
| − | : [[t(2;2)(p23;q13) RANBP2/ALK]]
| |
| − | : [[t(2;21)(p11;q22) RUNX1/?]]
| |
| − | : [[t(2;3)(p15-23;q26-27) ?/MECOM]]
| |
| − | : [[t(2;3)(p16;q26) BCL11A/MECOM]]
| |
| − | : [[t(2;3)(p21;q26) THADA/MECOM]]
| |
| − | : [[t(2;4)(p23;q25-q35)]]
| |
| − | : [[t(3;11)(p25;p15) ANKRD28/NUP98]]
| |
| − | : [[t(3;11)(q12;p15) NUP98/LNP1]]
| |
| − | : [[t(3;11)(q13.13;q23) KMT2A/KIAA1524]]
| |
| − | : [[t(3;12)(q26;p13) ETV6/EVI1]]
| |
| − | : [[t(3;12)(q26;p13) ETV6/MECOM]]
| |
| − | : [[t(3;16)(q21;q22)]]
| |
| − | : [[t(3;17)(q26;q22) ?/MECOM]]
| |
| − | : [[t(3;21)(p12;q22) RUNX1/?]]
| |
| − | : [[t(3;21)(q26;q22) RUNX1/MECOM]]
| |
| − | : [[t(3;3)(q21;q26) PSMD2/MECOM]]
| |
| − | : [[t(3;4)(p21;q34)]]
| |
| − | : [[t(3;5)(p21;q32) RBM6/CSF1R]]
| |
| − | : [[t(3;5)(q21;q31)]]
| |
| − | : [[t(3;5)(q25;q34) NPM1/MLF1]]
| |
| − | : [[t(3;5)(q26;q34) ?/MECOM]]
| |
| − | : [[t(3;6)(q25;q26) ?/MECOM]]
| |
| − | : [[t(3;7)(q26;q21) MECOM/CDK6]]
| |
| − | : [[t(3;8)(q21;q24) in myeloid malignancies]]
| |
| − | : [[t(3;8)(q26;q24) PVT1/MECOM]]
| |
| − | : [[t(4;11)(q21;q23) KMT2A/AFF1]]
| |
| − | : [[t(4;11)(q35;q23) KMT2A/SORBS2]]
| |
| − | : [[t(4;12)(q12;p13) CHIC2/ETV6]]
| |
| − | : [[t(4;17)(q12;q21) FIP1L1/RARA]]
| |
| − | : [[t(4;21)(q31;q22) RUNX1/SH3D19]]
| |
| − | : [[t(4;5)(q31;q31)]]
| |
| − | : [[t(5;11)(q31;q23) KMT2A/ARHGAP26]]
| |
| − | : [[t(5;11)(q35;p15.5) NUP98/NSD1]]
| |
| − | : [[t(5;11)(q35;q12) NSD1/FEN1]]
| |
| − | : [[t(5;12)(p13;p13) NIPBL/ETV6]]
| |
| − | : [[t(5;12)(q13;p13) ?/ETV6]]
| |
| − | : [[t(5;12)(q31;p13) ETV6/ACSL6 in MDS,AML and AEL]]
| |
| − | : [[t(5;12)(q33;p13) ERC1/PDGFRB]]
| |
| − | : [[t(5;14)(q33;q32) PDGFRB/TRIP11]]
| |
| − | : [[t(5;14)(q35;q11) TRD/NKX2-5]]
| |
| − | : [[t(5;16)(q33;q22)]]
| |
| − | : [[t(5;17)(q35;q21) NPM1/RARA]]
| |
| − | : [[t(5;21)(q13;q22) RUNX1/?]]
| |
| − | : [[t(6;11)(q13;q23) KMT2A-SMAP1]]
| |
| − | : [[t(6;11)(q15;q23) KMT2A/?]]
| |
| − | : [[t(6;11)(q27;q23) KMT2A/MLLT4]]
| |
| − | : [[t(6;14)(q25-27;q32) BCL11B/?]]
| |
| − | : [[t(6;20)(q13;q12) LMBRD1/CHD6]]
| |
| − | : [[t(6;22)(p21;q11)]]
| |
| − | : [[t(6;8)(q27;p12) FGFR1OP/FGFR1]]
| |
| − | : [[t(6;9)(p22;q34) DEK/NUP214]]
| |
| − | : [[t(7;11)(p15;p15) NUP98/HOXA9]]
| |
| − | : [[t(7;12)(q36;p13) MNX1/ETV6]]
| |
| − | : [[t(7;14)(q21;q13)]]
| |
| − | : [[t(7;14)(q22;q11)]]
| |
| − | : [[t(7;14)(q35;q32.1) TRB/TCL1A]]
| |
| − | : [[t(7;21)(p15;q22) RUNX1/?]]
| |
| − | : [[t(7;21)(p22;q22) RUNX1/USP42]]
| |
| − | : [[t(7;8)(q34;p11) TRIM24/FGFR1]]
| |
| − | : [[t(8;11)(p11;p15) NUP98/WHSC1L1]]
| |
| − | : [[t(8;11)(p12;p15) ?/FGFR1]]
| |
| − | : [[t(8;12)(q12;p13)]]
| |
| − | : [[t(8;12)(q13;p13) ETV6/NCOA2]]
| |
| − | : [[t(8;16)(p11;p13) KAT6A/CREBBP]]
| |
| − | : [[t(8;19)(p11;q13) ERVK-6/FGFR1]]
| |
| − | : [[t(8;19)(p11;q13) KAT6A/?]]
| |
| − | : [[t(8;20)(p11;q13) KAT6A/NCOA3]]
| |
| − | : [[t(8;21)(q22;q22) RUNX1/RUNX1T1]]
| |
| − | : [[t(8;21)(q24;q22) RUNX1/TRPS1]]
| |
| − | : [[t(8;22)(p11;q13) KAT6A/EP300]]
| |
| − | : [[t(8;9)(p22;p24) PCM1/JAK2]]
| |
| − | : [[t(9;11)(p22;p15) NUP98/PSIP1]]
| |
| − | : [[t(9;11)(p22;q23) KMT2A/MLLT3]]
| |
| − | : [[t(9;11)(q34;p15) NUP98/PRRX2]]
| |
| − | : [[t(9;11)(q34;q23) FNBP1/KMT2A]]
| |
| − | : [[t(9;11)(q34;q23) KMT2A/DAB2IP]]
| |
| − | : [[t(9;12)(q34;p13) ETV6/ABL1]]
| |
| − | : [[t(9;21)(q34;q22) RUNX1 truncated]]
| |
| − | : [[t(9;22)(q34;q11) BCR/ABL1 in AML]]
| |
| − | : [[t(9;9)(q34;q34) SET/NUP214]]
| |
| − | : [[t(X;10)(p10;p10)]]
| |
| − | : [[t(X;11)(q13;q23) KMT2A/FOXO4]]
| |
| − | : [[t(X;11)(q22;q23) KMT2A/?]]
| |
| − | : [[t(X;11)(q24;q23) KMT2A/SEPT6]]
| |
| − | : [[t(X;11)(q26;q23)]]
| |
| − | : [[t(X;17)(p11;q21) BCOR/RARA]]
| |
| − | : [[t(X;21)(p22;q22) RUNX1/RPL22]]
| |
| − | : [[t(X;21)(q26;q22) ELF4/ERG]]
| |
| − | : [[t(X;6)(p11;q23) MYB/GATA1]]
| |
| | | | |
| − | ==B-Cell Acute Lymphocytic Leukaemias (B-ALL)== | + | ==Isochromsomes== |
| | | | |
| − | : [[+10 or trisomy 10 (solely)]]
| + | {| class="wikitable" |
| − | : [[+13 or trisomy 13]]
| + | |+ISOCHROMOSOMES |
| − | : [[+15 or trisomy 15 (as sole autosomal abnormality)]]
| + | |- |
| − | : [[+16 or trisomy 16 (solely)]]
| + | |'''ANOMALY''' |
| − | : [[+18 or trisomy 18 in lymphoproliferative disorders]]
| + | |'''ASSOCIATED DISORDERS with FISH test''' |
| − | : [[+21 or trisomy 21]]
| + | |'''GENES''' |
| − | : [[+4 or trisomy 4]]
| + | |- |
| − | : [[+6 or trisomy 6]]
| + | |[[i(1)(q10)]] |
| − | : [[+8 or trisomy 8]]
| + | |[[NHL ]] |
| − | : [[+9 or trisomy 9]]
| + | |- |
| − | : [[-21 or monosomy 21 (solely)]]
| + | |[[i(3)(q10)]] |
| − | : [[11q23 rearrangements (KMT2A) in childhood acute lymphoblastic leukemia]]
| + | |[[NHL ]] |
| − | : [[11q23 rearrangements (KMT2A) in leukaemia]]
| + | |- |
| − | : [[12p rearrangements (ETV6) in ALL]]
| + | |[[i(7)(q10) ]] |
| − | : [[15q13-15 Rearrangements]]
| + | |[[T-cell lymphoma]] |
| − | : [[9p Rearrangements in ALL]]
| + | |- |
| − | : [[Biphenotypic Acute Leukaemia (BAL)]]
| + | |[[i(8)(q10)]] |
| − | : [[Congenital leukaemias]]
| + | |[[T-PLL]],[[ AML]],[[ B-ALL]] |
| − | : [[High hyperdiploid acute lymphoblastic leukaemia]]
| + | |- |
| − | : [[Infant leukaemias]]
| + | |[[i(11)(q10) ]] |
| − | : [[Near haploid acute lymphoblastic leukaemia]]
| + | |[[AML M2]],[[ M4]],[[ MDS]] |
| − | : [[Neonatal leukaemias]]
| + | |- |
| − | : [[Severe hypodiploid acute lymphoblastic leukaemia]]
| + | |[[i(17)(q10)]] |
| − | : [[Trisomy 5]]
| + | |[[MDS]],[[ MPD]],[[ AML]],[[ CML]],[[ B-ALL]],[[ CLL]],[[ Hodgkin and NHL]] |
| − | : [[del(13q) in ALL]]
| + | |- |
| − | : [[del(6q) abnormalities in lymphoid malignancies]]
| + | |[[i(21)(q10)]] |
| − | : [[del(9)(p13p24) PAX5/JAK2]]
| + | |[[B-ALL]],[[ MDS]],[[ NHL]],[[ AML]],[[ CMML]] |
| − | : [[dic(3;9)(p14;p13) PAX5/FOXP1]]
| + | |- |
| − | : [[dic(7;9)(p11-12;p12-13) PAX5/LOC392027]]
| + | |[[idic(X)(q13)]] |
| − | : [[dic(7;9)(p11-13;p11)]]
| + | |[[AML M1]],[[ M2]],[[ M4]],[[ MDS]],[[ RARS]] |
| − | : [[dic(9;12)(p13;p12) PAX5/SLCO1B3]]
| + | |[[XIST]] |
| − | : [[dic(9;12)(p13;p13) PAX5/ETV6]]
| + | |} |
| − | : [[dic(9;16)(p13;q11) PAX5/?]]
| |
| − | : [[dic(9;17)(p13;q11) PAX5/TAOK1]]
| |
| − | : [[dic(9;18)(p13;q11) PAX5/ZNF521]]
| |
| − | : [[dic(9;20)(p11-13;q11) PAX5/Various]]
| |
| − | : [[dup(21q) amplified (RUNX1)]]
| |
| − | : [[i(6)(p10)]]
| |
| − | : [[i(9q) in ALL]]
| |
| − | : [[ins(5;11)(q31;q13q23) KMT2A/AFF4]]
| |
| − | : [[ins(X;11)(q26;q23q23)]]
| |
| − | : [[inv(11)(q13q23) KMT2A/BTBD18]]
| |
| − | : [[inv(14)(q11q32) CEBPE/IGH]]
| |
| − | : [[inv(14)(q11q32.1) TRA-TRD/TCL1A]]
| |
| − | : [[inv(19)(p13q13) TCF3/TFPT]]
| |
| − | : [[inv(9)(p13p24) PAX5/JAK2]]
| |
| − | : [[t(10;11)(p12;q23) KMT2A/MLLT10]]
| |
| − | : [[t(10;11)(p13;q21) PICALM/MLLT10]]
| |
| − | : [[t(10;11)(q22;q23) KMT2A/TET1]]
| |
| − | : [[t(11;16)(q23;p13.3) KMT2A/CREBBP]]
| |
| − | : [[t(11;17)(q23;p13) KMT2A/GAS7]]
| |
| − | : [[t(11;17)(q23;q25) KMT2A/SEPT9]]
| |
| − | : [[t(11;19)(q23;p13.3) KMT2A/ACER1]]
| |
| − | : [[t(11;19)(q23;p13.3) KMT2A/MLLT1]]
| |
| − | : [[t(11;20)(q23;q11) KMT2A/MAPRE1]]
| |
| − | : [[t(12;12)(p13;q13) ETV6/BAZ2A]]
| |
| − | : [[t(12;13)(p12;q12-14) ETV6/CDX2]]
| |
| − | : [[t(12;13)(p13;q14) LIN00598/ETV6]]
| |
| − | : [[t(12;14)(p13;q32) IGH/ETV6]]
| |
| − | : [[t(12;17)(p13;q11) TAF15/ZNF384]]
| |
| − | : [[t(12;17)(p13;q11-21) in ALL]]
| |
| − | : [[t(12;19)(p13;p13) TCF3/ZNF384]]
| |
| − | : [[t(12;21)(p13;q22) ETV6/RUNX1]]
| |
| − | : [[t(12;22)(p13;q12) EWSR1/ZNF384]]
| |
| − | : [[t(13;19)(q14;p13) TCF3/?]]
| |
| − | : [[t(14;14)(q11;q32) CEBPE/IGH]]
| |
| − | : [[t(14;14)(q11;q32.1) TRA-TRD/TCL1A]]
| |
| − | : [[t(14;18)(q32;q21) IGH/BCL2]]
| |
| − | : [[t(14;19)(q32;q13) IGH/CEBPA]]
| |
| − | : [[t(14;20)(q32;q13) IGH/CEBPB]]
| |
| − | : [[t(17;19)(q22;p13) TCF3/HLF]]
| |
| − | : [[t(18;22)(q21;q11) IGL/BCL2]]
| |
| − | : [[t(19;19)(p13;q13) TCF3/TFPT]]
| |
| − | : [[t(1;11)(p32;q23) KMT2A/EPS15]]
| |
| − | : [[t(1;14)(q21;q32)]]
| |
| − | : [[t(1;14)(q21;q32) BCL9/IGH]]
| |
| − | : [[t(1;14)(q25;q32) IGH/LHX4]]
| |
| − | : [[t(1;18)(q25;q23)]]
| |
| − | : [[t(1;19)(q23;p13) TCF3/PBX1]]
| |
| − | : [[t(1;2)(q12;q37)]]
| |
| − | : [[t(1;22)(q21;q11)]]
| |
| − | : [[t(1;22)(q21;q11) IGL/BCL9]]
| |
| − | : [[t(1;3)(p36;p21)]]
| |
| − | : [[t(1;5)(q22;q33) PDE4DIP/PDGFRB]]
| |
| − | : [[t(1;9)(p13;p12) PAX5/HIPK1]]
| |
| − | : [[t(1;9)(p34;q34) SFPQ/ABL1]]
| |
| − | : [[t(1;9)(q24;q34) RCSD1/ABL1]]
| |
| − | : [[t(2;11)(p21;q23) KMT2A/?]]
| |
| − | : [[t(2;14)(p13-16;q32) IGH/BCL11A]]
| |
| − | : [[t(2;18)(p11;q21) IGK/BCL2]]
| |
| − | : [[t(2;8)(p12;q24) IGK/MYC]]
| |
| − | : [[t(2;9)(p11;p13) PAX5/?]]
| |
| − | : [[t(2;9)(q37;q34) INPP5D-ABL1]]
| |
| − | : [[t(3;11)(q21;q23) KMT2A/EEFSEC]]
| |
| − | : [[t(4;11)(p12;q23) KMT2A/FRYL]]
| |
| − | : [[t(4;11)(q21;q23) KMT2A/AFF1]]
| |
| − | : [[t(4;12)(q12;p13) CHIC2/ETV6]]
| |
| − | : [[t(5;11)(q31;q23) KMT2A/ARHGAP26]]
| |
| − | : [[t(5;14)(q31;q32) IGH/IL3]]
| |
| − | : [[t(5;15)(p15;q11-13)]]
| |
| − | : [[t(5;9)(q14.1;p24) SSBP2/JAK2]]
| |
| − | : [[t(6;12)(p21;p13) CCND3/ETV6 in lymphoid malignancies]]
| |
| − | : [[t(6;14)(p22;q32) IGH/ID4]]
| |
| − | : [[t(6;14)(q25-27;q32) BCL11B/?]]
| |
| − | : [[t(6;22)(p21;q11)]]
| |
| − | : [[t(7;12)(q36;p13) MNX1/ETV6]]
| |
| − | : [[t(7;14)(q35;q32.1) TRB/TCL1A]]
| |
| − | : [[t(7;9)(q11.2;p13.2) PAX5/AUTS2]]
| |
| − | : [[t(7;9)(q11;p12) PAX5/POM121]]
| |
| − | : [[t(7;9)(q11;p13) PAX5/ELN]]
| |
| − | : [[t(8;12)(q13;p13) ETV6/NCOA2]]
| |
| − | : [[t(8;14)(q11;q32) IGH/CEBPD]]
| |
| − | : [[t(8;14)(q24;q11) TRA/MYC]]
| |
| − | : [[t(8;14)(q24;q32) IGH/MYC]]
| |
| − | : [[t(8;22)(q24;q11) IGL/MYC]]
| |
| − | : [[t(8;9)(p22;p24) PCM1/JAK2]]
| |
| − | : [[t(8;9)(q24;p13) ?/MYC]]
| |
| − | : [[t(8;9)(q24;q13)]]
| |
| − | : [[t(9;10)(q34;q22) ZMIZ1/ABL1]]
| |
| − | : [[t(9;12)(p24;p13) ETV6/JAK2]]
| |
| − | : [[t(9;12)(q34;p13) ETV6/ABL1]]
| |
| − | : [[t(9;13)(p12;q21) PAX5/DACH1]]
| |
| − | : [[t(9;15)(p13;q24) PAX5/GOLGA6A]]
| |
| − | : [[t(9;15)(p13;q24) PAX5/PML]]
| |
| − | : [[t(9;17)(p13;p12) PAX5/NCOR1]]
| |
| − | : [[t(9;22)(p13;q13) PAX5/BRD1]]
| |
| − | : [[t(9;22)(q34;q11) BCR/ABL1 in ALL]]
| |
| − | : [[t(9;9)(p13;p24) PAX5/JAK2]]
| |
| − | : [[t(X;11)(q22;q23) KMT2A/?]]
| |
| − | : [[t(X;11)(q26;q23)]]
| |
| − | : [[t(X;9)(q21;p13) PAX5/DACH2]]
| |
| | | | |
| − | ==T-Cell Acute Lymphocytic Leukaemias (T-ALL)== | + | ==Cryptic== |
| | | | |
| − | : [[+20 or trisomy 20 (solely)]]
| + | {| class="wikitable" |
| − | : [[+4 or trisomy 4]]
| + | |+CRYPTIC |
| − | : [[+7 or trisomy 7 (solely)]]
| + | |- |
| − | : [[+8 or trisomy 8]]
| + | |'''ANOMALY''' |
| − | : [[+9 or trisomy 9]]
| + | |'''ASSOCIATED DISORDERS with FISH test''' |
| − | : [[11q23 rearrangements (KMT2A) in childhood acute lymphoblastic leukemia]]
| + | |'''GENES''' |
| − | : [[11q23 rearrangements (KMT2A) in leukaemia]]
| + | |- |
| − | : [[12p rearrangements (ETV6) in ALL]]
| + | |[[t(12;21)(p13;q22)]] |
| − | : [[15q13-15 Rearrangements]]
| + | |[[B-ALL]] |
| − | : [[1p32 rearrangements]]
| + | |[[ETV6 (TEL)-RUNX1(AML1)]] |
| − | : [[9p Rearrangements in ALL]]
| + | |- |
| − | : [[Biphenotypic Acute Leukaemia (BAL)]]
| + | |[[t(X;14)]] |
| − | : [[NK cell neoplasias]]
| + | |[[B-ALL]] |
| − | : [[NUP214/ABL1 fusion gene on amplified episomes]]
| + | |[[CRLF2-IGH]] |
| − | : [[T-lineage acute lymphoblastic leukemia (T-ALL)]]
| + | |- |
| − | : [[del(11)(p12p13) LMO2]]
| + | |[[t(Y;14)]] |
| − | : [[del(13q) in ALL]]
| + | |[[B-ALL]] |
| − | : [[del(6q) abnormalities in lymphoid malignancies]]
| + | |[[CRLF2-IGH]] |
| − | : [[del(9q) solely]]
| + | |- |
| − | : [[dic(9;12)(p13;p13) PAX5/ETV6]]
| + | |[[t(5;14)(q35;q32)]] |
| − | : [[i(6)(p10)]]
| + | |[[T-ALL]] |
| − | : [[inv(14)(q11q32.1) TRA-TRD/TCL1A]]
| + | |[[TLX3-BCL11B]] |
| − | : [[inv(7)(p15q34) TRB/HOXA10]]
| + | |- |
| − | : [[t(10;11)(p13;q21) PICALM/MLLT10]]
| + | |[[del(1)(p32p32)]] |
| − | : [[t(10;11)(q25;p15) NUP98/ADD3]]
| + | |[[B-ALL]] |
| − | : [[t(10;14)(q24;q11) TRD/TLX1]]
| + | |[[TAL1-STIL]] |
| − | : [[t(11;14)(p13;q11) TRD/LMO2]]
| + | |} |
| − | : [[t(11;14)(p15;q11) TRD/LMO1]]
| |
| − | : [[t(11;18)(p15;q12) NUP98/SETBP1]]
| |
| − | : [[t(11;19)(q23;p13.3) KMT2A/MLLT1]]
| |
| − | : [[t(12;12)(p13;q13) ETV6/BAZ2A]]
| |
| − | : [[t(12;13)(p12;q12-14) ETV6/CDX2]]
| |
| − | : [[t(12;14)(p13;q11) TRA or TRD/CCND2]]
| |
| − | : [[t(14;14)(q11;q32.1) TRA-TRD/TCL1A]]
| |
| − | : [[t(14;21)(q11;q22) TRA/OLIG2]]
| |
| − | : [[t(1;12)(q21;p13) ETV6/ARNT]]
| |
| − | : [[t(1;14)(p32;q11) TRA/TAL1]]
| |
| − | : [[t(1;19)(q23;p13) TCF3/PBX1]]
| |
| − | : [[t(1;2)(p36;p21) PRDM16 and LINC00982/?]]
| |
| − | : [[t(1;3)(p32;p21) TCTA/TAL1]]
| |
| − | : [[t(1;5)(p32;q31) ?/TAL1]]
| |
| − | : [[t(1;7)(p32;q34) TRB/TAL1]]
| |
| − | : [[t(1;7)(p34;q34) TRB/LCK]]
| |
| − | : [[t(2;14)(p13-16;q32) IGH/BCL11A]]
| |
| − | : [[t(2;21)(q11;q22)]]
| |
| − | : [[t(3;11)(q12;p15) NUP98/LNP1]]
| |
| − | : [[t(3;11)(q29;p15) NUP98/IQCG]]
| |
| − | : [[t(4;11)(q21;p15) NUP98/RAP1GDS1]]
| |
| − | : [[t(4;11)(q21;q23) KMT2A/AFF1]]
| |
| − | : [[t(4;21)(q31;q22) RUNX1/?]]
| |
| − | : [[t(5;12)(q13;p13) ?/ETV6]]
| |
| − | : [[t(5;14)(q35;q11) TRD/NKX2-5]]
| |
| − | : [[t(5;14)(q35;q32) BCL11B/TLX3]]
| |
| − | : [[t(5;14)(q35;q32.2) BCL11B/TLX3 and NKX2-5]]
| |
| − | : [[t(5;17)(q13;q21)]]
| |
| − | : [[t(5;6)(q33-34;q23) CEP85L/PDGFRB]]
| |
| − | : [[t(5;7)(q35;q21) TLX3/CDK6]]
| |
| − | : [[t(6;11)(q27;q23) KMT2A/MLLT4]]
| |
| − | : [[t(6;7)(q23;q34) TRB/MYB and AHI1]]
| |
| − | : [[t(7;10)(q34;q24) TRD/TLX1]]
| |
| − | : [[t(7;11)(q35;p13) TBB/LMO2]]
| |
| − | : [[t(7;12)(q34;p13) TRB/CCND2]]
| |
| − | : [[t(7;14)(p15;q11) TRD/HOXA10]]
| |
| − | : [[t(7;14)(q35;q32.1) TRB/TCL1A]]
| |
| − | : [[t(7;19)(q34;p13) TRB/LYL1]]
| |
| − | : [[t(7;7)(p15;q34) TRB/HOXA10]]
| |
| − | : [[t(7;9)(q34;q32) TRB/TAL2]]
| |
| − | : [[t(7;9)(q34;q34) TRB-NOTCH1]]
| |
| − | : [[t(8;12)(q13;p13) ETV6/NCOA2]]
| |
| − | : [[t(8;14)(q24;q11) TRA/MYC]]
| |
| − | : [[t(8;21)(q24;q22) RUNX1/TRPS1]]
| |
| − | : [[t(8;9)(p22;p24) PCM1/JAK2]]
| |
| − | : [[t(9;12)(p24;p13) ETV6/JAK2]]
| |
| − | : [[t(9;12)(q34;p13) ETV6/ABL1]]
| |
| − | : [[t(9;14)(q34;q32) EML1/ABL1]]
| |
| − | : [[t(9;22)(q34;q11) BCR/ABL1 in ALL]]
| |
| − | : [[t(X;11)(q13;q23) KMT2A/FOXO4]]
| |
| − | : [[t(X;7)(q22;q34) IRS4/TRB]]
| |
| | | | |
| − | ==Non Hodgkin Lymphomas (NHL)==
| |
| | | | |
| − | : [[Classification of B-cell non-Hodgkin's lymphomas (NHL)]]
| + | ==Deletions== |
| − | : [[+12 or trisomy 12]]
| |
| − | : [[+18 or trisomy 18 in lymphoproliferative disorders]]
| |
| − | : [[+20 or trisomy 20 (solely)]]
| |
| − | : [[+3 or trisomy 3 in non Hodgkin's lymphoma (NHL)]]
| |
| − | : [[+8 or trisomy 8]]
| |
| − | : [[12p rearrangements in CLL]]
| |
| − | : [[15q13-15 Rearrangements]]
| |
| − | : [[1q triplication in hematologic malignancies]]
| |
| − | : [[3q27 rearrangements (BCL6) in non Hodgkin lymphoma]]
| |
| − | : [[ALK -positive diffuse large B-cell lymphoma]]
| |
| − | : [[Anaplastic B-cell lymphoma]]
| |
| − | : [[Anaplastic large cell lymphoma (ALCL)]]
| |
| − | : [[Angioimmunoblastic T-cell lymphoma]]
| |
| − | : [[Burkitt's lymphoma (BL)]]
| |
| − | : [[Centroblastic lymphoma]]
| |
| − | : [[Classification of B-cell non-Hodgkin lymphomas (NHL)]]
| |
| − | : [[Classification of T-Cell disorders]]
| |
| − | : [[Cutaneous T-cell lymphomas]]
| |
| − | : [[Diffuse large cell lymphoma]]
| |
| − | : [[Follicular lymphoma (FL)]]
| |
| − | : [[Hepatosplenic T-cell lymphoma (HSTCL)]]
| |
| − | : [[Hodgkin lymphoma]]
| |
| − | : [[Immunoblastic lymphoma]]
| |
| − | : [[Intestinal T-cell lymphoma]]
| |
| − | : [[Lymphoepithelioid lymphoma]]
| |
| − | : [[Lymphoplasmacytic lymphoma]]
| |
| − | : [[Mantle cell lymphoma (incomplete)]]
| |
| − | : [[Marginal Zone B-cell lymphoma]]
| |
| − | : [[Mucosa-associated lymphoid tissue (MALT) lymphoma]]
| |
| − | : [[Mycosis fungoides/Sezary's syndrome]]
| |
| − | : [[NK cell neoplasias]]
| |
| − | : [[Nasal T cell lymphoma]]
| |
| − | : [[Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS)]]
| |
| − | : [[Primary cutaneous CD30+ anaplastic large cell lymphoma]]
| |
| − | : [[Small lymphocytic lymphoma]]
| |
| − | : [[T-cell large granular lymphocyte leukaemia]]
| |
| − | : [[T-cell/histiocyte-rich large B cell lymphoma]]
| |
| − | : [[Waldenstrom's macroglobulinemia (WM)]]
| |
| − | : [[del (13q)]]
| |
| − | : [[del(11q) in non-Hodgkin's lymphoma (NHL)]]
| |
| − | : [[del(13q) in non-Hodgkin's lymphoma]]
| |
| − | : [[del(17p) in non-Hodgkin's lymphoma (NHL)]]
| |
| − | : [[del(3)(q27q27) ST6GAL1/BCL6]]
| |
| − | : [[del(6q) abnormalities in lymphoid malignancies]]
| |
| − | : [[del(7q) in non-Hodgkin's lymphoma (NHL)]]
| |
| − | : [[dic(9;12)(p13;p13) PAX5/ETV6]]
| |
| − | : [[ins(12;8)(p11;p12p22) FGFR1OP2/FGFR1]]
| |
| − | : [[inv(14)(q11q32.1) TRA-TRD/TCL1A]]
| |
| − | : [[inv(18)(p11q21)]]
| |
| − | : [[inv(2)(p23q35) ATIC/ALK]]
| |
| − | : [[inv(7)(p15q34) TRB/HOXA10]]
| |
| − | : [[t(10;11)(q22;q23) KMT2A/TET1]]
| |
| − | : [[t(10;14)(q24;q11) TRD/TLX1]]
| |
| − | : [[t(11;14)(q13;q32) IGH/CCND1]]
| |
| − | : [[t(11;18)(q21;q21) BIRC3/MALT1]]
| |
| − | : [[t(12;14)(p13;q32) IGH/CCND2]]
| |
| − | : [[t(12;22)(p13;q11) IGL/CCND2]]
| |
| − | : [[t(14;14)(q11;q32.1) TRA-TRD/TCL1A]]
| |
| − | : [[t(14;15)(q32;q11) IGH/NBEAP1]]
| |
| − | : [[t(14;18)(q32;q21) IGH/BCL2]]
| |
| − | : [[t(14;18)(q32;q21) IGH/MALT1]]
| |
| − | : [[t(14;19)(q32;q13) IGH/BCL3]]
| |
| − | : [[t(14;22)(q32;q11) IGH/IGL]]
| |
| − | : [[t(18;22)(q21;q11) IGL/BCL2]]
| |
| − | : [[t(19;22)(q13;q11) BCL3/IGL]]
| |
| − | : [[t(1;1)(p36;q21) in Non Hodgkin Lymphoma]]
| |
| − | : [[t(1;13)(q32;q14)]]
| |
| − | : [[t(1;14)(p22;q32) IGH/BCL10]]
| |
| − | : [[t(1;14)(q21;q32)]]
| |
| − | : [[t(1;14)(q21;q32) BCL9/IGH]]
| |
| − | : [[t(1;14)(q21;q32) FCGR2B/IGH]]
| |
| − | : [[t(1;14)(q21;q32) FCRL4/IGH]]
| |
| − | : [[t(1;14)(q21;q32) MUC1/IGH]]
| |
| − | : [[t(1;16)(q11;q11)]]
| |
| − | : [[t(1;19)(q23;p13) TCF3/PBX1]]
| |
| − | : [[t(1;2)(p22;p12) IGK/BCL10]]
| |
| − | : [[t(1;2)(q25;p23) TPM3/ALK]]
| |
| − | : [[t(1;22)(q21;q11)]]
| |
| − | : [[t(1;22)(q21;q11) IGL/BCL9]]
| |
| − | : [[t(1;3)(p36;p21)]]
| |
| − | : [[t(1;3)(q25;q27) GAS5/BCL6]]
| |
| − | : [[t(1;7)(q21;q22)]]
| |
| − | : [[t(1;8)(p22-p32;q22-q23)]]
| |
| − | : [[t(2;12)(p12;p13) IGK/CCND2]]
| |
| − | : [[t(2;12)(q31;p13) ETV6/?]]
| |
| − | : [[t(2;14)(p13-16;q32) IGH/BCL11A]]
| |
| − | : [[t(2;17)(p23;q23) CLTC/ALK]]
| |
| − | : [[t(2;17)(p23;q25) RNF213/ALK]]
| |
| − | : [[t(2;18)(p11;q21) IGK/BCL2]]
| |
| − | : [[t(2;18)(q11;q21) AFF3/BCL2]]
| |
| − | : [[t(2;19)(p12;q13) IGK/BCL3]]
| |
| − | : [[t(2;19)(p23;p13) TPM4/ALK]]
| |
| − | : [[t(2;22)(p23;q11) CLTCL1/ALK]]
| |
| − | : [[t(2;22)(p23;q11) MYH9/ALK]]
| |
| − | : [[t(2;3)(p12;q27) IGK/BCL6]]
| |
| − | : [[t(2;3)(p23;q21) TFG/ALK]]
| |
| − | : [[t(2;5)(p23;q35) NPM1/ALK]]
| |
| − | : [[t(2;5)(p23;q35) SQSTM1/ALK]]
| |
| − | : [[t(2;6)(p12;p25) IRF4/IGK]]
| |
| − | : [[t(2;8)(p12;q24) IGK/MYC]]
| |
| − | : [[t(2;8)(p15;q24) BCL11A/MYC]]
| |
| − | : [[t(2;9)(p23;q33) TRAF1/ALK]]
| |
| − | : [[t(3;11)(q27;q23) POU2AF1/BCL6]]
| |
| − | : [[t(3;12)(q27;p12) LRMP/BCL6]]
| |
| − | : [[t(3;12)(q27;p13) GAPDH/BCL6]]
| |
| − | : [[t(3;13)(q27;q14) LCP1/BCL6]]
| |
| − | : [[t(3;14)(p14;q32) IGH/FOXP1]]
| |
| − | : [[t(3;14)(q21;q32)]]
| |
| − | : [[t(3;14)(q27;q32) HSP90AA1/BCL6]]
| |
| − | : [[t(3;14)(q27;q32) IGH/BCL6]]
| |
| − | : [[t(3;16)(q27;p11) IL21R/BCL6]]
| |
| − | : [[t(3;16)(q27;p13) CIITA/BCL6]]
| |
| − | : [[t(3;19)(q27;q13) NAPA/BCL6]]
| |
| − | : [[t(3;22)(q27;q11) IGL/BCL6]]
| |
| − | : [[t(3;3)(q25;q27) MBNL1/BCL6]]
| |
| − | : [[t(3;3)(q27;q27) ST6GAL1/BCL6]]
| |
| − | : [[t(3;3)(q27;q28) EIF4A2/BCL6]]
| |
| − | : [[t(3;3)(q27;q29) TFRC/BCL6]]
| |
| − | : [[t(3;4)(q27;p13) RHOH/BCL6]]
| |
| − | : [[t(3;6)(q27;p21)]]
| |
| − | : [[t(3;6)(q27;p21) PIM1/BCL6]]
| |
| − | : [[t(3;6)(q27;p21) SRSF3/BCL6]]
| |
| − | : [[t(3;6)(q27;p22) HIST1H4I/BCL6]]
| |
| − | : [[t(3;6)(q27;q14) SNHG5/BCL6]]
| |
| − | : [[t(3;6)(q27;q15) ?/BCL6]]
| |
| − | : [[t(3;7)(q27;p12) IKZF1-BCL6]]
| |
| − | : [[t(3;7)(q27;q32) FRA7H/BCL6]]
| |
| − | : [[t(3;7)(q27;q32) MIR29A/BCL6]]
| |
| − | : [[t(3;8)(q27;q24) BCL6/MYC]]
| |
| − | : [[t(3;9)(q26;p23) ?/MECOM]]
| |
| − | : [[t(3;9)(q27;p13) GRHPR/BCL6]]
| |
| − | : [[t(3;9)(q27;p24) DMRT1/BCL6]]
| |
| − | : [[t(3;Var)(q27;Var) in non Hodgkin lymphoma]]
| |
| − | : [[t(4;12)(p16;p13) ETV6/FGFR3]]
| |
| − | : [[t(4;16)(q26;p13) IL2/TNFRSF17]]
| |
| − | : [[t(5;9)(q33;q22) ITK/SYK]]
| |
| − | : [[t(6;12)(p21;p13) CCND3/ETV6 in lymphoid malignancies]]
| |
| − | : [[t(6;14)(p25.3;q11.2) TRA/IRF4]]
| |
| − | : [[t(6;14)(p25;q32) IRF4/IGH]]
| |
| − | : [[t(6;20)(q15;q11.2) BACH2/BCL2L1]]
| |
| − | : [[t(6;22)(p25;q11) IRF4/IGL]]
| |
| − | : [[t(6;7)(p25.3;q32.3) DUSP22/FRA7H]]
| |
| − | : [[t(6;8)(q11;q11)]]
| |
| − | : [[t(6;8)(q27;p12) FGFR1OP/FGFR1]]
| |
| − | : [[t(7;10)(q34;q24) TRD/TLX1]]
| |
| − | : [[t(7;14)(q35;q32.1) TRB/TCL1A]]
| |
| − | : [[t(7;7)(p15;q34) TRB/HOXA10]]
| |
| − | : [[t(7;8)(p12;q24) /MYC]]
| |
| − | : [[t(8;12)(p12;p11) FGFR1OP2/FGFR1]]
| |
| − | : [[t(8;12)(q24;p12) LRMP/MYC]]
| |
| − | : [[t(8;13)(p11;q12) ZMYM2/FGFR1]]
| |
| − | : [[t(8;14)(q24;q11) TRA/MYC]]
| |
| − | : [[t(8;14)(q24;q32) IGH/MYC]]
| |
| − | : [[t(8;22)(q24;q11) IGL/MYC]]
| |
| − | : [[t(8;9)(p22;p24) PCM1/JAK2]]
| |
| − | : [[t(8;9)(q24;p13) ?/MYC]]
| |
| − | : [[t(8;9)(q24;q13)]]
| |
| − | : [[t(9;14)(p13;q32) PAX5/IGH]]
| |
| − | : [[t(X;14)(p11.4;q32.33) IGH/GPR34]]
| |
| − | : [[t(X;2)(q11;p23) MSN/ALK]]
| |
| | | | |
| − | ==Chronic Lymphoproliferative Diseases (CLD)== | + | {| class="wikitable" |
| | + | |+DELETIONS |
| | + | |- |
| | + | |'''ANOMALY''' |
| | + | |'''ASSOCIATED DISORDERS with FISH test''' |
| | + | |'''GENES''' |
| | + | |- |
| | + | |[[del(1)(p32p36)]] |
| | + | |[[NHL]],[[ MM]] |
| | + | |- |
| | + | |[[del(1)(p32-34p36.1)]] |
| | + | |- |
| | + | |[[del(1)(p36.1)]] |
| | + | |[[Neuroblastoma]] |
| | + | |[[TP73(P73)]] |
| | + | |- |
| | + | |[[del(3)(p13p21)]] |
| | | | |
| − | : [[Classification of B-cell chronic lymphoproliferative disorders (CLD)]]
| + | |- |
| − | : [[+12 or trisomy 12]]
| + | |[[del(3)(q21)]] |
| − | : [[+15 or trisomy 15 (as sole autosomal abnormality)]]
| + | |[[B-ALL]],[[ AML]],[[ NHL]] |
| − | : [[+16 or trisomy 16 (solely)]]
| + | |
| − | : [[+18 or trisomy 18 in lymphoproliferative disorders]]
| + | |- |
| − | : [[+20 or trisomy 20 (solely)]]
| + | |[[del(5)(q13q33) ]] |
| − | : [[+8 or trisomy 8]]
| + | |[[AML]],[[ MDS]],[[ MPD]] |
| − | : [[-21 or monosomy 21 (solely)]]
| + | |[[ PDGFRB]] |
| − | : [[12p rearrangements in CLL]]
| + | |- |
| − | : [[1q rearrangements in multiple myeloma]]
| + | |[[del(5)(q15q33) ]] |
| − | : [[1q triplication in hematologic malignancies]]
| + | |[[AML]],[[ MDS]],[[ MPD]] |
| − | : [[Adult T-cell leukemia/lymphoma (ATLL)]]
| + | |[[ PDGFRB ]] |
| − | : [[B-cell prolymphocytic leukemia (B-PLL)]]
| + | |- |
| − | : [[Chronic lymphocytic leukaemia (CLL)]]
| + | |[[del(5)(q22q35) ]] |
| − | : [[Classification of B-cell chronic lymphoproliferative disorders (CLD)]]
| + | |[[AML]],[[ MDS]],[[ MPD]] |
| − | : [[Classification of T-Cell disorders]]
| + | |[[ PDGFRB ]] |
| − | : [[Fibrogenesis imperfecta ossium]]
| + | |- |
| − | : [[Hairy Cell Leukemia (HCL) and Hairy Cell Leukemia Variant (HCL-V)]]
| + | |[[del(5)(q31q35)]] |
| − | : [[Lymphomatoid papulosis (LyP) with 6p25.3 rearrangement DUSP22 and IRF4/]]
| + | |[[AML]],[[ MDS]],[[ MPD]] |
| − | : [[Multiple myeloma]]
| + | |[[ PDGFRB ]] |
| − | : [[Plasma cell leukemia (PCL)]]
| + | |- |
| − | : [[Polyclonal B Lymphocytosis with Binucleated Lymphocytes (PPBL)]]
| + | |[[del(6)(q13q21)]] |
| − | : [[Splenic lymphoma with villous lymphocytes (SLVL)]]
| + | |[[WM/LPL]],[[ MM]],[[ NK lymphoma]],[[ DLBCL]] |
| − | : [[T-cell prolymphocytic leukemia (T-PLL)]]
| + | |[[BLMP1-PRDM1]] |
| − | : [[del (13q)]]
| + | |- |
| − | : [[del(13q) in chronic lymphoproliferative diseases]]
| + | |[[del(6)(q13q23) A]] |
| − | : [[del(13q) in multiple myeloma]]
| + | |[[CLL]],[[ atypical CLL]],[[ FL]],[[ MCL]],[[ T-NHL]],[[ childhood B-ALL]],[[ childhood T-ALL]],[[ adult ALL]],[[ MM]] |
| − | : [[del(6q) abnormalities in lymphoid malignancies]]
| + | |- |
| − | : [[del(6q) in Multiple Myeloma]]
| + | |[[del(6)(q15q21)]] |
| − | : [[inv(14)(q11q32.1) TRA-TRD/TCL1A]]
| + | |
| − | : [[inv(19)(p13q13) TCF3/TFPT]]
| + | |- |
| − | : [[t(11;14)(p11;q32)]]
| + | |[[del(6)(q21) A]] |
| − | : [[t(11;14)(q13;q32) IGH/CCND1]]
| + | |[[CLL]],[[ atypical CLL]],[[ AML]],[[ childhood B-ALL]],[[ childhood T-ALL]],[[ adult ALL]],[[ MM]] |
| − | : [[t(11;14)(q13;q32) IGH/CCND1 in multiple myeloma]]
| + | |- |
| − | : [[t(13;19)(q14;p13) TCF3/?]]
| + | |[[del(7)(p15)]] |
| − | : [[t(14;14)(q11;q32.1) TRA-TRD/TCL1A]]
| + | |- |
| − | : [[t(14;18)(q32;q21) IGH/BCL2]]
| + | |[[del(7)(p13) ]] |
| − | : [[t(14;19)(q32;q13) IGH/BCL3]]
| + | |[[AML]],[[ NHL]] |
| − | : [[t(14;22)(q32;q11) IGH/IGL]]
| + | |- |
| − | : [[t(18;22)(q21;q11) IGL/BCL2]]
| + | |[[del(7)(p13p15)]] |
| − | : [[t(19;19)(p13;q13) TCF3/TFPT]]
| + | |
| − | : [[t(19;22)(q13;q11) BCL3/IGL]]
| + | |- |
| − | : [[t(1;14)(q21;q32) FCRL4/IGH]]
| + | |[[del(7)(p11.2)]] |
| − | : [[t(1;3)(p36;q21) PSMD2/PRDM16]]
| + | |[[B-ALL]],[[ AML]],[[ MDS]] |
| − | : [[t(1;6)(p35;p25) ?/IRF4]]
| + | |- |
| − | : [[t(1;6)(p36;p21)]]
| + | |[[del(7)(q11.2)]] |
| − | : [[t(2;14)(p13-16;q32) IGH/BCL11A]]
| + | |[[B-ALL]],[[ AML]],[[ MDS]] |
| − | : [[t(2;18)(p11;q21) IGK/BCL2]]
| + | |
| − | : [[t(2;19)(p12;q13) IGK/BCL3]]
| + | |- |
| − | : [[t(2;6)(p12;p25) IRF4/IGK]]
| + | |[[del(7)(q22q34) A]] |
| − | : [[t(2;7)(p11;q21) IGK/CDK6]]
| + | |[[AML]],[[ MDS]],[[ NHL]] |
| − | : [[t(4;14)(p16;q32) IGH/FGFR3 and WHSC1]]
| + | |
| − | : [[t(6;12)(p21;p13) CCND3/ETV6 in lymphoid malignancies]]
| + | |- |
| − | : [[t(6;14)(p21;q32) IGH/CCND3]]
| + | |[[del(7)(q32q34) A]] |
| − | : [[t(6;14)(p25;q32) IRF4/IGH]]
| + | |[[AML]],[[ MDS]],[[ NHL]] |
| − | : [[t(6;14)(q25-27;q32) BCL11B/?]]
| + | |
| − | : [[t(6;22)(p21;q11)]]
| + | |- |
| − | : [[t(6;22)(p25;q11) IRF4/IGL]]
| + | |[[del(7)(q32) A]] |
| − | : [[t(7;14)(q21;q32) ERVW-1/IgH]]
| + | |[[AML]],[[ MDS]],[[ NHL]] |
| − | : [[t(7;14)(q21;q32) IGH/CDK6]]
| + | |- |
| − | : [[t(7;14)(q35;q32.1) TRB/TCL1A]]
| + | |[[del(8)(p21)]] |
| − | : [[t(7;22)(q21;q11) IGL/CDK6]]
| + | |- |
| − | : [[t(8;12)(q24;q22) BTG1/MYC]]
| + | |[[del(8)(q22)]] |
| − | : [[t(8;17)(q24;q22) ???BCL3/MYC]]
| + | |- |
| − | : [[t(9;14)(p13;q32) PAX5/IGH]]
| + | |[[del(9)(p13)]] |
| − | : [[t(X;11)(q21;q23) BRWD3/ARHGAP20]]
| + | |[[B-ALL]],[[ NHL]],[[ pediatric B-ALL ]] |
| | + | |
| | + | |- |
| | + | |[[del(9)(p13p22)]] |
| | + | |[[B-ALL]] |
| | + | |- |
| | + | |[[del(9)(p21)]] |
| | + | |[[B-ALL]],[[ AML]],[[ NHL]] |
| | + | |
| | + | |- |
| | + | |[[del(9)(p22) ]] |
| | + | |[[B-ALL]] |
| | + | |
| | + | |- |
| | + | |[[del(9)(q13) ]] |
| | + | |[[AML M1]],[[ M2]],[[ M4]],[[ M6]] |
| | + | |
| | + | |- |
| | + | |[[del(9)(q13q22)]] |
| | + | |[[AML]],[[ MDS]] |
| | + | |
| | + | |- |
| | + | |[[del(10)(q24)]] |
| | + | |
| | + | |- |
| | + | |[[del(11)(p11.2) ]] |
| | + | |[[NHL]] |
| | + | |
| | + | |- |
| | + | |[[del(11)(p12p13) ]] |
| | + | |[[B-ALL]] |
| | + | |[[LMO2]] |
| | + | |- |
| | + | |[[del(11)(q13)]] |
| | + | |Missing |
| | + | |- |
| | + | |[[del(11)(q13q21)]] |
| | + | |Missing |
| | + | |- |
| | + | |[[del(11)(q13q23)]] |
| | + | |[[AML]],[[ CLL]],[[ MDS]],[[ NHL]] |
| | + | |[[ATM]] |
| | + | |- |
| | + | |[[del(11)(q21q23)]] |
| | + | |[[AML]] |
| | + | |[[MLL]] |
| | + | |- |
| | + | |[[del(11)(q23) ]] |
| | + | |[[AML]],[[ B-ALL]],[[ CLL]],[[ MDS]],[[ NHL]] |
| | + | |[[MLL]] |
| | + | |- |
| | + | |[[add(12)(p)/ del(12)(p11.2p13)]] |
| | + | |[[AML]],[[ MDS]],[[ B-ALL]] |
| | + | |[[ETV6(TEL)]] |
| | + | |- |
| | + | |[[del(13)(q12q14) A B]] |
| | + | |[[AML]],[[ AMM]],[[ MDS]],[[ NHL]] |
| | + | |
| | + | |- |
| | + | |[[del(13)(q12q22) A B]] |
| | + | |[[AML]],[[ PMF]],[[ CLL]],[[ MM]],[[ MDS]],[[ NHL]] |
| | + | |- |
| | + | |[[del(14)(q24) ]] |
| | + | |[[NHL]] |
| | + | |- |
| | + | |[[del(16)(q22) ]] |
| | + | |[[AML]],[[ AML-M4Eo]],[[ NHL]] |
| | + | |
| | + | |- |
| | + | |[[del(17)(p11.2) A]] |
| | + | |[[B-ALL]],[[ AML]],[[ CLL]],[[ MDS]],[[ NHL]] |
| | + | |[[TP53(P53)]] |
| | + | |- |
| | + | |[[del(18)(q21)]] |
| | + | |[[AML]],[[ NHL]] |
| | + | |
| | + | |- |
| | + | |[["del(20)(q11.2q13.1) |
| | + | del(20)(q11.2q13.3)"]] |
| | + | |[[AML]],[[ MDS]],[[ MPD]] |
| | + | |- |
| | + | |[[ider(20)(p11.1)del(20)(q11.2q13.3)]] |
| | + | |[[AML]],[[ MDS]],[[ MPD]] |
| | + | |[[" |
| | + | |- |
| | + | |[[del(X)(q24)]] |
| | + | |[[NHL]] |
| | + | |
| | + | |} |
| | + | |
| | + | ==Numerical Abnormalities== |
| | + | |
| | + | {| class="wikitable" |
| | + | |+NUMERICAL |
| | + | |- |
| | + | |'''ANOMALY''' |
| | + | |'''ASSOCIATED DISORDERS with FISH test''' |
| | + | |'''GENES''' |
| | + | |- |
| | + | |[[+3]] |
| | + | |[[SLVL]],[[ T-cell lymphoma]],[[ MZL]],[[ MCL]],[[ MALT]] |
| | + | |- |
| | + | |[[+4]] |
| | + | |[[AML M1-M2 and M4]],[[ and treatment related AML]] |
| | + | |- |
| | + | |[[+8]] |
| | + | |[[B-ALL]],[[ AML]],[[ MPD]],[[ MDS]],[[ PV]] |
| | + | |- |
| | + | |[[+9]] |
| | + | |[[AML]],[[ MDS]],[[ MPD]],[[ PV]],[[ B-ALL]],[[ T-ALL]] |
| | + | |- |
| | + | |[[+10]] |
| | + | |[[AML]],[[ B-ALL]],[[ MDS]] |
| | + | |- |
| | + | |[[+11]] |
| | + | |[[AML M1]],[[ M2]],[[ M4]],[[ MDS ]] |
| | + | |- |
| | + | |[[+12]] |
| | + | |[[AML]],[[ CLL]],[[ NHL]],[[ MALT]],[[ HCL]],[[ SLVL]],[[ WM/LPL]],[[ FL]],[[ MCL and DLBCL]] |
| | + | |- |
| | + | |[[+13/+13,+13]] |
| | + | |[[AML-M0]] |
| | + | |- |
| | + | |[[+14]] |
| | + | |[[MDS RA]],[[ RAEB±T mainly]],[[ AML M1]],[[ M2]],[[ M4]],[[ atypical MPD]] |
| | + | |- |
| | + | |[[+15]] |
| | + | |Age related when sole anomaly or with -Y |
| | + | |- |
| | + | |[[+19]] |
| | + | |[[AML]],[[ MDS]] |
| | + | |- |
| | + | |[[+21]] |
| | + | |[[AML]],[[ B-ALL]],[[ MDS]],[[ MPD]] |
| | + | |- |
| | + | |[[+22]] |
| | + | |[[AML-M4eo]] |
| | + | |- |
| | + | |[[-7 A B]] |
| | + | |[[MDS]],[[ RAEB/RAEB±T]],[[ CMML]],[[ J-CML]],[[ AML most often M4 or M6.]] |
| | + | |- |
| | + | |[[-Y ]] |
| | + | |age related when sole anomaly |
| | | | |
| − | ==Other==
| + | |} |
| | | | |
| − | : [[Castleman's disease]]
| + | ==Primarily Pediatric== |
| | + | |
| | + | {| class="wikitable" |
| | + | |+PEDIATRIC |
| | + | |- |
| | + | |'''ANOMALY''' |
| | + | |'''ASSOCIATED DISORDERS with FISH test''' |
| | + | |'''GENES''' |
| | + | |- |
| | + | |[[t(1;19)(q23;p13.3)]] |
| | + | |[[B-ALL]] |
| | + | |[[PBX1-TCF3(E2A)]] |
| | + | |- |
| | + | |[[der(19)t(1;19)(q23;p13.3)]] |
| | + | |[[B-ALL]] |
| | + | |[[PBX1-TCF3(E2A)]] |
| | + | |- |
| | + | |[[t(8;14)(q11;q32)]] |
| | + | |[[B-ALL]] |
| | + | |[[CEBPD-IGH]] |
| | + | |- |
| | + | |[[i(9)(q10)/idic(9)(q10)]] |
| | + | |[[B-ALL]] |
| | + | |- |
| | + | |[[dic(9;12)(p11;p11.2)]] |
| | + | |[[B-ALL]] |
| | + | |- |
| | + | |[[dic(9;20)(p11;q11)]] |
| | + | |[[B-ALL]] |
| | + | |[[PAX5]] |
| | + | |- |
| | + | |[[t(17;19)(q22;p13)]] |
| | + | |[[B-ALL]] |
| | + | |[[TCF3(E2A)-HLF]] |
| | + | |- |
| | + | |[[t(1;22)(p13;q13)]] |
| | + | |[[AML M7]] |
| | + | |[[RBM15-MKL1]] |
| | + | |- |
| | + | |[[t(10;11)(p13;q23) ]] |
| | + | |[[Primarily AML ]],[[ uncommonly B-ALL]] |
| | + | |[[MLLT10(AF10)/MLL]] |
| | + | |- |
| | + | |[[t(16;21)(p11.2;q22)]] |
| | + | |[[AML]] |
| | + | |[[FUS-ERG]] |
| | + | |- |
| | + | |[[t(16;21)(q24;q22)]] |
| | + | |[[AML]] |
| | + | |[[CBFA2T3-RUNX1-(AML1)]] |
| | + | |- |
| | + | |[[t(10;11)(p13;q14)]] |
| | + | |[[T-ALL]] |
| | + | |[[MLLT10(AF10)/PICALM ]] |
| | + | |- |
| | + | |[[t(11;14)(p15;q11.2)]] |
| | + | |[[T-ALL]] |
| | + | |[[LMO1-TRA]] |
| | + | |- |
| | + | |[[t(11;14)(p13;q11-q11.2) ]] |
| | + | |[[T-ALL]] |
| | + | |[[LMO2(Rhom2)-TRA]] |
| | + | |
| | + | |} |