Melanocytic Lesions: Difference between revisions
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{| class="wikitable" | {| class="wikitable" | ||
|'''Gene''' | |'''Gene''' | ||
|'''Function/Potential Role | |'''Function / Potential Role''' | ||
|- | |- | ||
|''ADAM30'' | |''ADAM30'' | ||
|Limited functional evidence | |Limited functional evidence supporting a driver role in melanoma | ||
|- | |- | ||
|''BPTF'' | |''BPTF'' | ||
|Chromatin remodeler | |Chromatin remodeler with context-dependent oncogenic properties | ||
|- | |- | ||
|''CYP24'' | |''CYP24'' | ||
|Vitamin D metabolism | |Vitamin D metabolism gene; indirect relevance to tumor biology | ||
|- | |||
|''EP300'' | |||
|Histone acetyltransferase; may function as coactivator or tumor suppressor depending on context | |||
|- | |||
|''KIRREL'' | |||
|Limited mechanistic validation as melanoma driver | |||
|- | |||
|''MKL1'' | |||
|Transcriptional coactivator; context-dependent oncogenic activity | |||
|- | |||
|''NOTCH2'' | |||
|Context-dependent signaling with oncogenic and tumor-suppressive roles depending on cellular context | |||
|- | |||
|''PDE11A'' | |||
|Phosphodiesterase with unclear contribution to melanoma progression | |||
|- | |||
|''PDE4DIP'' | |||
|Scaffold protein; no consistent evidence of recurrent oncogenic activation in melanoma | |||
|- | |||
|''PHIP'' | |||
|Implicated in melanoma progression but mechanistically complex and not a canonical oncogene | |||
|- | |||
|''PIK3C2G'' | |||
|PIK3 family member; limited evidence of recurrent activating alterations in melanoma | |||
|- | |||
|''S100A9, S100A10, S100A11, S100A12'' | |||
|Inflammatory mediators more commonly implicated in tumor microenvironment modulation than as primary genomic drivers | |||
|- | |||
|''SS18L1'' | |||
|Transcriptional regulator without clear melanoma driver validation | |||
|- | |||
|''CALML5'' | |||
|Calcium-binding protein; limited oncogenic validation | |||
|- | |||
|''CD274 (PD-L1)'' | |||
|Immune checkpoint regulator; deletion effects are context-dependent | |||
|- | |||
|''CDK10'' | |''CDK10'' | ||
|Cell-cycle regulator | |Cell-cycle regulator; limited melanoma-specific driver evidence | ||
|- | |- | ||
|''CHEK1'' | |''CHEK1'' | ||
|DNA damage kinase | |DNA damage response kinase; dual context-dependent role | ||
|- | |- | ||
|''ETS1'' | |''ETS1'' | ||
|Transcription factor | |Transcription factor with context-dependent oncogenic properties | ||
|- | |- | ||
|''IL15RA'' | |''IL15RA'' | ||
|Immune regulatory receptor | |Immune regulatory receptor; indirect tumor role | ||
|- | |- | ||
|''JAK2'' | |''JAK2'' | ||
|Oncogenic kinase | |Oncogenic kinase; loss not typical driver event in melanoma | ||
|- | |- | ||
|''LARP4B'' | |''LARP4B'' | ||
|RNA-binding protein | |RNA-binding protein; insufficient evidence as melanoma driver | ||
|- | |- | ||
|''MYB'' | |''MYB'' | ||
|Canonical oncogene | |Canonical oncogene; loss does not represent typical driver mechanism in melanoma | ||
|- | |- | ||
|''NET1'' | |''NET1'' | ||
|RhoA GEF | |RhoA GEF; limited melanoma-specific evidence | ||
|- | |- | ||
|''PRDM16'' | |''PRDM16'' | ||
| | |Context-dependent transcriptional regulator; not established as recurrent melanoma tumor suppressor | ||
|- | |- | ||
|''PRKCQ'' | |''PRKCQ'' | ||
| | |Kinase with signaling roles; melanoma-specific driver role unclear | ||
|- | |- | ||
|''YAP1'' | |''YAP1'' | ||
|Hippo pathway oncogene | |Hippo pathway oncogene; deletion suggests complex regional effects | ||
|} | |} | ||
==Reference== | ==Reference== | ||