Changes

CNS5:Diffuse hemispheric glioma, H3 G34-mutant (view source)

Revision as of 08:03, 2 May 2023

191 bytes removed , 08:03, 2 May 2023

m

→‎NPrimary Author(s)*

Line 1: Line 1: −

==~~NPrimary~~ Author(s)*==

+

==Primary Author(s)*==

Xiaolin Hu, PhD, Sema4 OpCo Inc.

Line 175: Line 175:

==Gene Mutations (SNV/INDEL/Methylation)==

−

~~Put your text here and fill in the table~~

+

<br />

{| class="wikitable sortable"

Line 185: Line 185:

!Notes

|-

−

|~~H3F3A~~ p.G35R/V

+

|''H3-3A'' p.G35R/V

|chromosome modification

|p.G35R 94%

Line 206: Line 206:

|

|-

−

|MGMT

+

|''MGMT''

|promoter methylation

|70%-74% of G34-DHG <ref name=":1" /><ref name=":4" />

Line 251: Line 251:

*DNA methylation and gene expression profiling can be used to differentiate G34-DHG with other glioma subgroups.

*''MGMT'' promoter methylation can be assessed by methylation specific polymerase chain reaction analysis (bisulfite treated DNA undergoes real-time PCR)<br />

−

~~==Familial Forms==~~

−

~~Put your text here~~

−

~~==Additional Information==~~

−

~~Put your text here~~

−

~~==Links==~~

−

~~Put your text placeholder here (use "Link" icon at top of page)~~

==References==

Laveniya.Satgunaseelan

Editors

31

edits