Changes

|N/A

|N/A

|}

|}

==Gene Mutations (SNV/INDEL)==

==Gene Mutations (SNV/INDEL/Methylation)==

Put your text here and fill in the table

Put your text here and fill in the table

!Notes

!Notes

|-

|-

|H3F3A

|H3F3A p.G35R/V

|p.G34R/V

|chromosome modification

|all of this cateogory

|TP53 inactivation mutations 83%;

ATRX mutations 93%

|TP53 inactivation mutations 90%;

ATRX mutations 95%

MGMT promoter methylation 70% <ref name=":1" />

MGMT promoter methylation 70% <ref name=":1" />

|IDH

 

PDGFRA 50-70%<ref>{{Cite journal|last=Chen|first=Carol C. L.|last2=Deshmukh|first2=Shriya|last3=Jessa|first3=Selin|last4=Hadjadj|first4=Djihad|last5=Lisi|first5=Véronique|last6=Andrade|first6=Augusto Faria|last7=Faury|first7=Damien|last8=Jawhar|first8=Wajih|last9=Dali|first9=Rola|date=2020-12-10|title=Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis|url=https://pubmed.ncbi.nlm.nih.gov/33259802|journal=Cell|volume=183|issue=6|pages=1617–1633.e22|doi=10.1016/j.cell.2020.11.012|issn=1097-4172|pmc=7791404|pmid=33259802}}</ref> <ref>{{Cite journal|last=Lucas|first=Calixto-Hope G.|last2=Mueller|first2=Sabine|last3=Reddy|first3=Alyssa|last4=Taylor|first4=Jennie W.|last5=Oberheim Bush|first5=Nancy Ann|last6=Clarke|first6=Jennifer L.|last7=Chang|first7=Susan M.|last8=Gupta|first8=Nalin|last9=Berger|first9=Mitchel S.|date=2021-11-02|title=Diffuse hemispheric glioma, H3 G34-mutant: Genomic landscape of a new tumor entity and prospects for targeted therapy|url=https://pubmed.ncbi.nlm.nih.gov/34519829|journal=Neuro-Oncology|volume=23|issue=11|pages=1974–1976|doi=10.1093/neuonc/noab184|issn=1523-5866|pmc=8628364|pmid=34519829}}</ref>

 

TERT

TERT

|Yes

|Yes

|

|

|

|

==Epigenomic Alterations==

==Epigenomic Alterations==

H3.3 G34R/V/D mutations impair di- or tri- methylation of lysine 36 by blocking the access to its lysine methyltransferase (e.g. SETD2) <ref>{{Cite journal|last=Shi|first=Leilei|last2=Shi|first2=Jiejun|last3=Shi|first3=Xiaobing|last4=Li|first4=Wei|last5=Wen|first5=Hong|date=2018-05-25|title=Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis|url=https://pubmed.ncbi.nlm.nih.gov/29689253|journal=Journal of Molecular Biology|volume=430|issue=11|pages=1562–1565|doi=10.1016/j.jmb.2018.04.014|issn=1089-8638|pmc=6450091|pmid=29689253}}</ref>. This attenuated interaction between SETD2 and H3 K36 alters genome wide methylation level and promote tumorigenesis.  

* H3.3 G34R/V/D mutations impair di- or tri- methylation of lysine 36 by blocking the access to its lysine methyltransferase SETD2 and lysine demethylase KDM2A <ref>{{Cite journal|last=Shi|first=Leilei|last2=Shi|first2=Jiejun|last3=Shi|first3=Xiaobing|last4=Li|first4=Wei|last5=Wen|first5=Hong|date=2018-05-25|title=Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis|url=https://pubmed.ncbi.nlm.nih.gov/29689253|journal=Journal of Molecular Biology|volume=430|issue=11|pages=1562–1565|doi=10.1016/j.jmb.2018.04.014|issn=1089-8638|pmc=6450091|pmid=29689253}}</ref><ref>{{Cite journal|last=Cheng|first=Zhongjun|last2=Cheung|first2=Peggie|last3=Kuo|first3=Alex J.|last4=Yukl|first4=Erik T.|last5=Wilmot|first5=Carrie M.|last6=Gozani|first6=Or|last7=Patel|first7=Dinshaw J.|date=2014-08-15|title=A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36|url=https://pubmed.ncbi.nlm.nih.gov/25128496|journal=Genes & Development|volume=28|issue=16|pages=1758–1771|doi=10.1101/gad.246561.114|issn=1549-5477|pmc=4197961|pmid=25128496}}</ref>. This attenuated interaction alters genome wide methylation level and promote tumorigenesis.  

==Genes and Main Pathways Involved==

==Genes and Main Pathways Involved==

|EXAMPLE: Increased cell growth and proliferation

|EXAMPLE: Increased cell growth and proliferation

|-

|-

|EXAMPLE: CDKN2A; Inactivating mutations

|MGMT; promoter methylatioin

|EXAMPLE: Cell cycle regulation

|EXAMPLE: Cell cycle regulation

|EXAMPLE: Unregulated cell division

|EXAMPLE: Unregulated cell division