Changes

==Definition / Description of Disease==

==Definition / Description of Disease==

Put your text here <span style="color:#0070C0">(''Instructions: Brief description of approximately one paragraph - include disease context relative to other WHO classification categories referring to the specific WHO book pages, diagnostic criteria if applicable, and differential diagnosis if applicable'') </span>

Inflammatory Myofibroblastic Tumor (IMT) of the breast originate from mesenchymal tissue and is composed of both myofibroblastic and fibroblastic spindle cells and is accompanied by an inflammatory infiltrate, which may include plasma cells, lymphocytes, and/or eosinophils. It has intermediate biological potential (low-grade malignant) and rarely metastasizes.  

 

Essential and desirable diagnostic criteria include loose fascicles of plump spindle cells without substantial atypia or pleomorphism; inflammatory infiltrate of lymphocytes and plasma cells; consistent SMA expression; frequent ALK expression; ''ALK'' or other gene rearrangements in some cases.

==Synonyms / Terminology==

==Synonyms / Terminology==