Changes

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{{Under Construction}}

<blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023-11-30. The original page can be found at [[HAEM4:Hairy Cell Leukemia Variant]].

<blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023-12-04. The original page can be found at [[HAEM4:Hairy Cell Leukemia Variant]].

Note: consider content on the overview page: Splenic B-cell Lymphoma/Leukemia, Unclassifiable

Note: consider content on the overview page: Splenic B-cell Lymphoma/Leukemia, Unclassifiable

==Cancer Category / Type==

==Cancer Category / Type==

*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]

*[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]

==Cancer Sub-Classification / Subtype==

==Cancer Sub-Classification / Subtype==

*HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults

*HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults

*Name derives from clinicopathologic similarity to [[Hairy Cell Leukemia|hairy cell leukemia]] (HCL) but with important differences

*Name derives from clinicopathologic similarity to [[HAEM5:Hairy cell leukaemia|hairy cell leukemia]] (HCL) but with important differences

*Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections

*Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections

*Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL)

*Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL)

|Positive||CD11c, CD72, CD103

|Positive||CD11c, CD72, CD103

|-

|-

|Negative ([[Hairy Cell Leukemia|HCL]] markers)||CD25, CD123, annexin A1, TRAP, BRAF V600E

|Negative ([[HAEM5:Hairy cell leukaemia|HCL]] markers)||CD25, CD123, annexin A1, TRAP, BRAF V600E

|-

|-

|Negative

|Negative

==Links==

==Links==

*[[Hairy Cell Leukemia]]

*[[HAEM5:Hairy cell leukaemia]]

*[[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]

*[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]

==References==

==References==