Changes

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<blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023-11-30. The original page can be found at [[HAEM4:Hairy Cell Leukemia]].

<blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023-12-04. The original page can be found at [[HAEM4:Hairy Cell Leukemia]].

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==Primary Author(s)*==

==Primary Author(s)*==

==Cancer Category / Type==

==Cancer Category / Type==

*[[Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]

*[[HAEM4:Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]

==Cancer Sub-Classification / Subtype==

==Cancer Sub-Classification / Subtype==

|BRAF p.Val600Glu

|BRAF p.Val600Glu

|Diagnostic

|Diagnostic

|May be useful when immunophenotype is equivocal; Excludes [[Hairy Cell Leukemia Variant|HCLv]]

|May be useful when immunophenotype is equivocal; Excludes [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]]

|-

|-

|MAP2K1

|MAP2K1

^‡Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal] and [https://cancer.sanger.ac.uk/cosmic COSMIC].

^‡Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal] and [https://cancer.sanger.ac.uk/cosmic COSMIC].

'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain.  These seem to be more similar molecularly and clinically to [[Hairy Cell Leukemia Variant|HCLv]].

'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain.  These seem to be more similar molecularly and clinically to [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]].

*BRAF and MAP2K1 activating mutations are mutually exclusive

*BRAF and MAP2K1 activating mutations are mutually exclusive

==Links==

==Links==

*[[Hairy Cell Leukemia Variant]]

*[[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli]]

*[[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]

*[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]

==References==

==References==