Changes

==Morphologic Features==

==Morphologic Features==

* Grossly, grey/tan solid mass within cortical and subcortical region with soft consistence, necrotic and hemorrhagic features.

*Grossly, grey/tan solid mass within cortical and subcortical region with soft consistence, necrotic and hemorrhagic features.

* Microscopically, heterogenous histological appearance including glioblastoma (GBM) and central nervous system embryonal tumor. GBM typically presents with highly cellularity, infiltrative astrocytic tumor. High mitotic activity and microvascular proliferation and necrosis are frequently seen. Embryonal tumors show hyperchromatic nuclei and scant cytoplasm with occasionally Homer-Wright rosettes appearance.

*Microscopically, heterogenous histological appearance including glioblastoma (GBM) and central nervous system embryonal tumor. GBM typically presents with highly cellularity, infiltrative astrocytic tumor. High mitotic activity and microvascular proliferation and necrosis are frequently seen. Embryonal tumors show hyperchromatic nuclei and scant cytoplasm with occasionally Homer-Wright rosettes appearance.

==Immunophenotype==

==Immunophenotype==

{| class="wikitable sortable"

{| class="wikitable sortable"

!Finding!!Marker

!Finding!!Marker

|-

|-

|Positive (universal)||EXAMPLE CD1

|Positive (universal)||MAP2, FOXG1, Ki-67, H3.3 p.G35R or p. G35V

|-

|-

|Positive (subset)||EXAMPLE CD2

|Positive (subset)||GFAP (GBM), synaptophysin (embryonal tumor), p53

|-

|-

|Negative (universal)||EXAMPLE CD3

|Negative (universal)||ATRX, Olig2

|-

|-

|Negative (subset)||EXAMPLE CD4

|Negative (subset)||

|}

|}