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HAEM4:Transient Abnormal Myelopoiesis (TAM) Associated with Down Syndrome (view source)
Revision as of 16:29, 4 December 2023
, 16:29, 4 December 2023no edit summary
[[AML|Acute Myeloid Leukemia]]
[[AML|Acute Myeloid Leukemia]]
[[Myeloid Proliferations Associated with Down Syndrome]]
[[HAEM4:Myeloid Proliferations Associated with Down Syndrome]]
==Cancer Sub-Classification / Subtype==
==Cancer Sub-Classification / Subtype==
==Definition / Description of Disease==
==Definition / Description of Disease==
This is a distinct entity in the World Health Organization (WHO) classification system within the section of [[Myeloid Proliferations Associated with Down Syndrome]]<ref name=":0">Arber DA, et al., (2017). Myeloid proliferations associated with Down syndrome, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p169-170.</ref>.
This is a distinct entity in the World Health Organization (WHO) classification system within the section of [[HAEM4:Myeloid Proliferations Associated with Down Syndrome]]<ref name=":0">Arber DA, et al., (2017). Myeloid proliferations associated with Down syndrome, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p169-170.</ref>.
Transient abnormal myelopoiesis (TAM) associated with Down syndrome (DS) is a unique disorder of newborns with DS that presents with clinical and morphological findings indistinguishable from those of acute myeloid leukemia. The blasts have morphological and immunological features of megakaryocytic lineage<ref name=":0" /><ref name=":1">{{Cite journal|last=Klusmann|first=Jan-Henning|last2=Creutzig|first2=Ursula|last3=Zimmermann|first3=Martin|last4=Dworzak|first4=Michael|last5=Jorch|first5=Norbert|last6=Langebrake|first6=Claudia|last7=Pekrun|first7=Arnulf|last8=Macakova-Reinhardt|first8=Katarina|last9=Reinhardt|first9=Dirk|date=2008|title=Treatment and prognostic impact of transient leukemia in neonates with Down syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/18182574|journal=Blood|volume=111|issue=6|pages=2991–2998|doi=10.1182/blood-2007-10-118810|issn=0006-4971|pmc=2265448|pmid=18182574}}</ref><ref name=":2">{{Cite journal|last=Gruber|first=Tanja A.|last2=Downing|first2=James R.|date=2015|title=The biology of pediatric acute megakaryoblastic leukemia|url=https://www.ncbi.nlm.nih.gov/pubmed/26186939|journal=Blood|volume=126|issue=8|pages=943–949|doi=10.1182/blood-2015-05-567859|issn=1528-0020|pmc=4551356|pmid=26186939}}</ref><ref name=":3">{{Cite journal|last=Bhatnagar|first=Neha|last2=Nizery|first2=Laure|last3=Tunstall|first3=Oliver|last4=Vyas|first4=Paresh|last5=Roberts|first5=Irene|date=2016|title=Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update|url=https://www.ncbi.nlm.nih.gov/pubmed/27510823|journal=Current Hematologic Malignancy Reports|volume=11|issue=5|pages=333–341|doi=10.1007/s11899-016-0338-x|issn=1558-822X|pmc=5031718|pmid=27510823}}</ref><ref name=":4">{{Cite journal|last=Bombery|first=Melissa|last2=Vergilio|first2=Jo-Anne|date=2014|title=Transient abnormal myelopoiesis in neonates: GATA get the diagnosis|url=https://www.ncbi.nlm.nih.gov/pubmed/25268193|journal=Archives of Pathology & Laboratory Medicine|volume=138|issue=10|pages=1302–1306|doi=10.5858/arpa.2014-0304-CC|issn=1543-2165|pmid=25268193}}</ref><ref name=":5">{{Cite journal|last=Saida|first=Satoshi|date=2016|title=Evolution of myeloid leukemia in children with Down syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/26910243|journal=International Journal of Hematology|volume=103|issue=4|pages=365–372|doi=10.1007/s12185-016-1959-5|issn=1865-3774|pmid=26910243}}</ref>.
Transient abnormal myelopoiesis (TAM) associated with Down syndrome (DS) is a unique disorder of newborns with DS that presents with clinical and morphological findings indistinguishable from those of acute myeloid leukemia. The blasts have morphological and immunological features of megakaryocytic lineage<ref name=":0" /><ref name=":1">{{Cite journal|last=Klusmann|first=Jan-Henning|last2=Creutzig|first2=Ursula|last3=Zimmermann|first3=Martin|last4=Dworzak|first4=Michael|last5=Jorch|first5=Norbert|last6=Langebrake|first6=Claudia|last7=Pekrun|first7=Arnulf|last8=Macakova-Reinhardt|first8=Katarina|last9=Reinhardt|first9=Dirk|date=2008|title=Treatment and prognostic impact of transient leukemia in neonates with Down syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/18182574|journal=Blood|volume=111|issue=6|pages=2991–2998|doi=10.1182/blood-2007-10-118810|issn=0006-4971|pmc=2265448|pmid=18182574}}</ref><ref name=":2">{{Cite journal|last=Gruber|first=Tanja A.|last2=Downing|first2=James R.|date=2015|title=The biology of pediatric acute megakaryoblastic leukemia|url=https://www.ncbi.nlm.nih.gov/pubmed/26186939|journal=Blood|volume=126|issue=8|pages=943–949|doi=10.1182/blood-2015-05-567859|issn=1528-0020|pmc=4551356|pmid=26186939}}</ref><ref name=":3">{{Cite journal|last=Bhatnagar|first=Neha|last2=Nizery|first2=Laure|last3=Tunstall|first3=Oliver|last4=Vyas|first4=Paresh|last5=Roberts|first5=Irene|date=2016|title=Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update|url=https://www.ncbi.nlm.nih.gov/pubmed/27510823|journal=Current Hematologic Malignancy Reports|volume=11|issue=5|pages=333–341|doi=10.1007/s11899-016-0338-x|issn=1558-822X|pmc=5031718|pmid=27510823}}</ref><ref name=":4">{{Cite journal|last=Bombery|first=Melissa|last2=Vergilio|first2=Jo-Anne|date=2014|title=Transient abnormal myelopoiesis in neonates: GATA get the diagnosis|url=https://www.ncbi.nlm.nih.gov/pubmed/25268193|journal=Archives of Pathology & Laboratory Medicine|volume=138|issue=10|pages=1302–1306|doi=10.5858/arpa.2014-0304-CC|issn=1543-2165|pmid=25268193}}</ref><ref name=":5">{{Cite journal|last=Saida|first=Satoshi|date=2016|title=Evolution of myeloid leukemia in children with Down syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/26910243|journal=International Journal of Hematology|volume=103|issue=4|pages=365–372|doi=10.1007/s12185-016-1959-5|issn=1865-3774|pmid=26910243}}</ref>.
==Other Information==
==Other Information==
Also see [[Myeloid Proliferations Associated with Down Syndrome]]
Also see [[HAEM4:Myeloid Proliferations Associated with Down Syndrome]]
==Links==
==Links==