| Line 94: |
Line 94: |
| | |} | | |} |
| | | | |
| − | ==Chromosomal Rearrangements (Gene Fusions)==
| |
| − |
| |
| − | {| class="wikitable sortable"
| |
| − | |-
| |
| − | !Chromosomal Rearrangement!!Genes in Fusion (5’ or 3’ Segments)!!Pathogenic Derivative!!Reference
| |
| − | |-
| |
| − | |t(5;9)(q33;q22)||''ITK'' / ''SYK''||der(5); der(9)||<ref>{{Cite journal|last=B|first=Streubel|last2=U|first2=Vinatzer|last3=M|first3=Willheim|last4=M|first4=Raderer|last5=A|first5=Chott|date=2006|title=Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/16341044/|language=en|pmid=16341044}}</ref><ref name=":4">{{Cite journal|last=M|first=Wang|last2=S|first2=Zhang|last3=Ss|first3=Chuang|last4=M|first4=Ashton-Key|last5=E|first5=Ochoa|last6=N|first6=Bolli|last7=G|first7=Vassiliou|last8=Z|first8=Gao|last9=Mq|first9=Du|date=2017|title=Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling|url=https://pubmed.ncbi.nlm.nih.gov/28148900/|language=en|doi=10.18632/oncotarget.14846|pmc=PMC5392284|pmid=28148900}}</ref>
| |
| − | |-
| |
| − | |t(7;14)(q35;q32.1)
| |
| − | |''TRB/TCL1A''
| |
| − | |der(7); der(14)
| |
| − | |<ref>{{Cite journal|last=Mf|first=Cosimi|last2=I|first2=Casagranda|last3=G|first3=Ghiazza|last4=G|first4=Rossi|last5=P|first5=Galvani|date=1990|title=Rearrangements on chromosomes 7 and 14 with breakpoints at 7q35 and 14q11 in angioimmunoblastic lymphadenopathy and IBL-like T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/2284141/|language=en|pmid=2284141}}</ref>
| |
| − | |-
| |
| − | |t(14;14)(q11;q32.1) / inv(14)(q11q32.1)
| |
| − | |''TRA-TRD/TCL1A''
| |
| − | |der(14)
| |
| − | |<ref>{{Cite journal|last=B|first=Schlegelberger|last2=A|first2=Feller|last3=A|first3=Himmler|last4=W|first4=Grote|date=1990|title=Inv(14)(q11q32) in one of four different clones in a case of angioimmunoblastic lymphadenopathy|url=https://pubmed.ncbi.nlm.nih.gov/2293883/|language=en|pmid=2293883}}</ref><ref>{{Cite journal|last=E|first=Leich|last2=E|first2=Haralambieva|last3=A|first3=Zettl|last4=A|first4=Chott|last5=T|first5=Rüdiger|last6=S|first6=Höller|last7=Hk|first7=Müller-Hermelink|last8=G|first8=Ott|last9=A|first9=Rosenwald|date=2007|title=Tissue microarray-based screening for chromosomal breakpoints affecting the T-cell receptor gene loci in mature T-cell lymphomas|url=https://pubmed.ncbi.nlm.nih.gov/17582237/|language=en|pmid=17582237}}</ref>
| |
| − | |-
| |
| − | |chr(2)(q33.2)
| |
| − | |''CTLA4/CD28''
| |
| − | |der(2)
| |
| − | |<ref>{{Cite journal|last=Hy|first=Yoo|last2=P|first2=Kim|last3=Ws|first3=Kim|last4=Sh|first4=Lee|last5=S|first5=Kim|last6=Sy|first6=Kang|last7=Hy|first7=Jang|last8=Je|first8=Lee|last9=J|first9=Kim|date=2016|title=Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/26819049/|language=en|doi=10.3324/haematol.2015.139253|pmc=PMC5013939|pmid=26819049}}</ref>
| |
| − | |}
| |
| − |
| |
| − | ==Characteristic Chromosomal Aberrations / Patterns==
| |
| − |
| |
| − | *Clonal rearrangement in T-Cell receptor gene in 75-90% of AITL cases<ref name=":7">{{Cite journal|last=Ad|first=Attygalle|last2=Ss|first2=Chuang|last3=Tc|first3=Diss|last4=Mq|first4=Du|last5=Pg|first5=Isaacson|last6=A|first6=Dogan|date=2007|title=Distinguishing angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified, using morphology, immunophenotype and molecular genetics|url=https://pubmed.ncbi.nlm.nih.gov/17448026/|language=en|pmid=17448026}}</ref> <ref>{{Cite journal|last=L|first=de Leval|last2=C|first2=Gisselbrecht|last3=P|first3=Gaulard|date=2010|title=Advances in the understanding and management of angioimmunoblastic T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/19961485/|language=en|pmid=19961485}}</ref><ref name=":8">{{Cite journal|last=Bt|first=Tan|last2=Ra|first2=Warnke|last3=Da|first3=Arber|date=2006|title=The frequency of B- and T-cell gene rearrangements and epstein-barr virus in T-cell lymphomas: a comparison between angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified with and without associated B-cell proliferations|url=https://pubmed.ncbi.nlm.nih.gov/16931587/|language=en|doi=10.2353/jmoldx.2006.060016|pmc=PMC1867616|pmid=16931587}}</ref>
| |
| − | *Clonal rearrangement in immunoglobulin genes in 25-30% of AITL cases<ref name=":7" /><ref name=":8" />
| |
| | | | |
| | ==Genomic Gain/Loss/LOH== | | ==Genomic Gain/Loss/LOH== |
| Line 217: |
Line 189: |
| | |} | | |} |
| | | | |
| − | ==Epigenomics (Methylation)==
| |
| | | | |
| − | *Frequent mutation in epigenetic modifiers like: <ref name=":4" /><ref name=":5" /><ref name=":11" /><ref name=":12" />
| |
| − | **''IDH2'' (20-30%)
| |
| − | **''TET2'' (50-80%)
| |
| − | **''DNMT3A'' (20-30%)
| |
| | | | |
| | ==Diagnostic Testing Methods== | | ==Diagnostic Testing Methods== |