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Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1
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According to "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues", blah, blah.
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According to "WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues",
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"...clinical and morphologic presentations associated with FGFR1 rearrangement are variable, and include not only presentation as a myeloproliferative neoplasm with eosinophilia, but also as AML and they may even present as, or evolve to, precursor T or B lymphoblastic leukaemia/lymphoma with prominent eosinphils." (p.28).
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FGFR1 rearrangements are used to rule out diagnoses of Chronic Eosinophilic Leukaemia (p.54) and Myeloproliferative neoplasm,unclassifiable (p.66).
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In the case of FGFR1-related disease,
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a lymphomatous presentation is common,
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particularly T-LBL with accompanying eosinophilia. Other patients have had CEL,
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precursor-B lymphoblastic leukaemia/
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lymphoma or AML. (.70).
==Gene Overview==
==Gene Overview==