495
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Changes
Translocations et al. in Hematological Cancers (view source)
Revision as of 11:45, 26 August 2016
, 11:45, 26 August 2016no edit summary
==Acknowledgement==
This list is based on the [http://www.mayomedicallaboratories.com/articles/features/hem-cyto/index.html '''Mayo Clinic Hematologic Cytogenetics Reference Sheet, November 2012'''].
__TOC__
__TOC__
|[[Translocation der(1)t(1;1)(p36;q21)|der(1)t(1;1)(p36;q21)]]
|[[Translocation der(1)t(1;1)(p36;q21)|der(1)t(1;1)(p36;q21)]]
|[[NHL]]
|[[NHL]]
|
|-
|-
|[[Translocation t(1;3)(p36;q21)|t(1;3)(p36;q21)]]
|[[Translocation t(1;3)(p36;q21)|t(1;3)(p36;q21)]]
|[[MDS]],[[ AML]]
|[[MDS]],[[AML]]
|[[PRDM16(MEL1)-RPN1]]
|[[PRDM16(MEL1)-RPN1]]
|-
|-
|[[t(1;3;5)(p36;p21;q33) ]]
|[[t(1;3;5)(p36;p21;q33)]]
|[[CEL]]
|[[CEL]]
|[[WDR48-PDGFRB]]
|[[WDR48-PDGFRB]]
|-
|-
|[[t(1;5)(q22;q33)]]
|[[t(1;5)(q22;q33)]]
|[[MPD with eosinophilia]],[[ CEL]],[[ B-ALL]]
|[[MPD]],[[ CEL]],[[ B-ALL]]
|[[PDE4DIP-PDGFRB]]
|[[PDE4DIP-PDGFRB]]
|-
|-
|[[der(1;7)(q10;p10)]]
|[[der(1;7)(q10;p10)]]
|[[MDS]],[[ AML]],[[ MPD]]
|[[MDS]],[[AML]],[[ MPD]]
|
|-
|-
|[[t(1;8)(p13;q24.1)]]
|[[t(1;8)(p13;q24.1)]]
|Missing
|
| [[MYC(C-MYC)]]
|[[MYC]]
|-
|-
|[[t(1;14)(q21;q32)]]
|[[t(1;14)(q21;q32)]]
|[[B-ALL]],[[ NHL]]
|[[B-ALL]],[[NHL]]
|[[BCL9-IGH]],[[ FCGR2B-IGH]],[[ FCRL4-IGH]],[[ MUC1/IGH]]
|[[IGH-BCL9]],[[IGH-FCGR2B]],[[IGH-FCRL4]],[[IGH-MUC1]]
|-
|-
|[[t(1;19)(q23;p13.3) ]]
|[[t(1;19)(q23;p13.3) ]]
|[[B-ALL]]
|[[B-ALL]]
|[[PBX1-TCF3(E2A)]]
|[[TCF3(E2A)-PBX1]]
|-
|[[Translocation der(16)t(1;16)(q21;q11.2)|der(16)t(1;16)(q21;q11.2)]]
|
|
|-
|-
|[[der(1;22)(q10;p10)]]
|[[der(1;22)(q10;p10)]]
|
|
|-
|-
|[[t(2;5)(p23;q35)]]
|[[t(2;5)(p23;q35)]]
|[[ALCL]],[[ NHL]]
|[[ALCL]],[[NHL]]
|[[ALK-NPM1]]
|[[NPM1-ALK]]
|-
|-
|[[t(2;8)(p12;q24.1)]]
|[[t(2;8)(p12;q24.1)]]
|[[BL]],[[ B-ALL]],[[ NHL ]]
|[[BL]],[[ B-ALL]],[[NHL]]
|[[MYC(C-MYC)]]
|[[MYC]]
|-
|-
|[[t(2;11)(p21;q23)]]
|[[t(2;11)(p21;q23)]]
|[[MDS]],[[ AML]],[[ B-ALL]]
|[[MDS]],[[AML]],[[B-ALL]]
|[[MLL]]
|[[KMT2A]]
|-
|-
|[[t(2;14)(p15;q32)]]
|[[t(2;14)(p15;q32)]]
|[[CLL]],[[ NHL]],[[ B-ALL]],[[ T-ALL]],[[ AML]]
|[[CLL]],[[ NHL]],[[ B-ALL]],[[ T-ALL]],[[AML]]
|
|-
|-
|[[t(3;3)(q21;q26.2) ]]
|[[Translocation t(3;3)(q21;q26.2) and Inversion inv(3)(q21q26.2)|t(3;3)(q21;q26.2)]]
|[[MDS]],[[ AML]]
|[[MDS]],[[AML]]
|[[RPN1-MECOM(EVI1)]]
|[[RPN1-MECOM(EVI1)]]
|-
|-
|[[t(3;5)(p21-25;q32-35)]]
|[[t(3;5)(p21-25;q32-35)]]
|[[MPD]]
|[[MPD]]
|[[GOLGA4-PDGFRB ]]
|[[GOLGA4-PDGFRB]]
|-
|-
|[[t(3;21)(q26.2;q22)]]
|[[t(3;21)(q26.2;q22)]]
|[[t(4;11)(q21;q23)]]
|[[t(4;11)(q21;q23)]]
|[[B-ALL]],[[ T-ALL]]
|[[B-ALL]],[[ T-ALL]]
|[[AFF1(AF4)-MLL]]
|[[KMT2A-AFF1]]
|-
|-
|[[t(4;14)(p16.3;q32)]]
|[[t(4;14)(p16.3;q32)]]
|[[MM]]
|[[MM]]
|[[ FGFR3-IGH]]
|[[IGH-FGFR3]]
|-
|-
|[[t(4;22)(q12;q11)]]
|[[t(4;22)(q12;q11)]]
|[[atypical MPD]]
|[[atypical MPD]]
|[[ PDGFRA -BCR]]
|[[BCR-PDGFRA]]
|-
|-
|[[t(4;5;5)(q23;q31;q33)]]
|[[t(4;5;5)(q23;q31;q33)]]
|[[chronic basophilic leukemia]]
|[[Chronic Basophilic Leukemia]]
|[[PRKG2-PDGFRB]]
|[[PRKG2-PDGFRB]]
|-
|-
|-
|-
|[[t(5;12)(q33;q24)]]
|[[t(5;12)(q33;q24)]]
|[[MPD with eosinophilia ]]
|[[MPD]]
|[[GIT2-PDGFRB]]
|[[GIT2-PDGFRB]]
|-
|-
|[[t(5;12)(q33;p13)]]
|[[t(5;12)(q33;p13)]]
|[[CMML]],[[ MDS]],[[ MPD]]
|[[CMML]],[[MDS]],[[MPD]]
|[[ETV6(TEL)-PDGFRB]]
|[[ETV6(TEL)-PDGFRB]]
|-
|-
|[[t(5;14)(q33;q24)]]
|[[t(5;14)(q33;q24)]]
|[[MPD]],[[ atypical MPD]]
|[[MPD]],[[MPD]]
|[[NIN-PDGFRB]]
|[[NIN-PDGFRB]]
|-
|-
|[[t(5;14)(q33;q32)]]
|[[t(5;14)(q33;q32)]]
|
|[[CCDC88C(KIAA1509)-PDGFRB]]
|[[CCDC88C(KIAA1509)-PDGFRB]]
|-
|-
|[[t(5;15)(q33;q22)]]
|[[t(5;15)(q33;q22)]]
|[[CMML atypical MPD]]
|[[CMML]],[[MPD]]
|[[TP53BP1-PDGFRB]]
|[[TP53BP1-PDGFRB]]
|-
|-
|-
|-
|[[der(5;17)(p10;q10)]]
|[[der(5;17)(p10;q10)]]
|[[MDS]],[[ AML]]
|[[MDS]],[[AML]]
|[[NPM1(NPM)-RARA]]
|[[NPM1(NPM)-RARA]]
|-
|-
|-
|-
|[[t(5;17)(q33;p13)]]
|[[t(5;17)(q33;p13)]]
|[[CMML]],[[ atypical MPD]]
|[[CMML]],[[MPD]]
|[[RABEP1-PDGFRB ]]
|[[RABEP1-PDGFRB ]]
|-
|-
|[[der(6)t(1;6)(q21;p21.3)]]
|[[der(6)t(1;6)(q21;p21.3)]]
|[[PMF]]
|[[PMF]]
|
|-
|-
|[[t(6;9)(p23;q34) ]]
|[[t(6;9)(p23;q34) ]]
|[[MDS]],[[ AML]]
|[[MDS]],[[AML]]
|[[DEK-NUP214 (CAN)]]
|[[DEK-NUP214 (CAN)]]
|-
|-
|[[t(6;11)(q27;q23) ]]
|[[t(6;11)(q27;q23) ]]
|[[AML]],[[ t-AML]],[[ T-ALL]]
|[[AML]],[[ t-AML]],[[T-ALL]]
|[[MLLT4(AF6)-MLL]]
|[[KMT2A-MLLT4]]
|-
|-
|[[t(7;11)(p15;p15)]]
|[[t(7;11)(p15;p15)]]
|[[t(8;14)(q24.1;q32) ]]
|[[t(8;14)(q24.1;q32) ]]
|[[BL]],[[ B-ALL]],[[ NHL]]
|[[BL]],[[ B-ALL]],[[ NHL]]
|[[MYC(C-MYC)- IGH]]
|[[IGH-MYC]]
|-
|-
|[[t(8;16)(p11.2;p13.3) A]]
|[[t(8;16)(p11.2;p13.3)]]
|[[AML M4]],[[ M5a]],[[ M5b]],[[ t-MDS]]
|[[AML]],[[t-MDS]]
|[[KAT6A(MYST3)-CREBBP(CBP)]]
|[[KAT6A(MYST3)-CREBBP(CBP)]]
|-
|-
|[[t(8;21)(q22;q22) A ]]
|[[t(8;21)(q22;q22) A ]]
|[[AML M2 mostly]],[[ rarely M1]],[[ M4]]
|[[AML]]
|[[RUNX1(AML)-RUNX1T1(ETO)]]
|[[RUNX1(AML)-RUNX1T1(ETO)]]
|-
|-
|[[t(8;22)(q24.1;q11.2) ]]
|[[t(8;22)(q24.1;q11.2) ]]
|[[BL]],[[ B-ALL]],[[ NHL]],[[ MM]]
|[[BL]],[[ B-ALL]],[[NHL]],[[ MM]]
|[[MYC(C-MYC)-IGL(IGL)]]
|[[IGL-MYC]]
|-
|-
|[[add(9)(p24)]]
|[[add(9)(p24)]]
|
|[[JAK2]]
|[[JAK2]]
|-
|-
|[[t(9;11)(p22;q23)]]
|[[t(9;11)(p22;q23)]]
|[[AML mostly M5]],[[ M4]],[[ B-ALL]]
|[[AML]],[[B-ALL]]
|[[MLLT3(AF9)-MLL]]
|[[KMT2A-MLLT3]]
|-
|-
|[[t(9;14)(p13;q32)]]
|[[t(9;14)(p13;q32)]]
|[[MM]],[[ CLL]],[[ DLBCL]],[[ FL]],[[ MCL splenic MZL]]
|[[MM]],[[CLL]],[[DLBCL]],[[FL]],[[MCL splenic MZL]]
|[[PAX5-IGH]]
|[[PAX5-IGH]]
|-
|-
|[[t(9;22)(q34;q11.2) A B ]]
|[[t(9;22)(q34;q11.2)]]
|[[CML]],[[ B-ALL]],[[ T-ALL]]
|[[CML]],[[ B-ALL]],[[T-ALL]]
|[[ABL1(ABL)-BCR]]
|[[ABL1(ABL)-BCR]]
|-
|-
|[[t(11;14)(q13;q32) A ]]
|[[t(11;14)(q13;q32)]]
|[[MCL]],[[ MM]]
|[[MCL]],[[ MM]]
|[[CCND1(BCL1)- IGH]]
|[[IGH-CCND1]]
|-
|-
|[[t(11;14)(q23;q32)]]
|[[t(11;14)(q23;q32)]]
|[[t-AML]]
|[[AML]]
|[[MLL-KIAA0284]]
|[[KMT2A-KIAA0284]]
|-
|-
|[[t(11;16)(q23;p13.3)]]
|[[t(11;16)(q23;p13.3)]]
|[[BIRC3(API2)-MALT1]]
|[[BIRC3(API2)-MALT1]]
|-
|-
|[[t(11;19)(q23;p13.1) ]]
|[[t(11;19)(q23;p13.1)]]
|[[AML]]
|[[AML]]
|[[MLL-ELL]]
|[[KMT2A-ELL]]
|-
|-
|[[t(11;19)(q23;p13.3) ]]
|[[t(11;19)(q23;p13.3)]]
|[[B-ALL]],[[ AML]],[[ T-ALL]]
|[[B-ALL]],[[AML]],[[T-ALL]]
|[[MLL-MLLT1(ENL)]]
|[[KMT2A-MLLT1]]
|-
|-
|[[t(14;16)(q32;q23)]]
|[[t(14;16)(q32;q23)]]
|[[IGH-MAF]]
|[[IGH-MAF]]
|-
|-
|[[t(14;18)(q32;q21) ]]
|[[t(14;18)(q32;q21)]]
|[[BL]],[[ DLBCL]],[[ FL]],[[ CLL]]
|[[BL]],[[DLBCL]],[[FL]],[[CLL]]
|[[IGH-BCL2]]
|[[IGH-BCL2]]
|-
|-
|[[t(14;19)(q32;q13.3)]]
|[[t(14;19)(q32;q13.3)]]
|[[CLL]],[[ DLBCL]],[[ MCL]],[[ MZL]],[[ SLVL]]
|[[CLL]],[[DLBCL]],[[MCL]],[[MZL]],[[SLVL]]
|[[IGH-BCL3]]
|-
|-
|[[t(14;19)(q32;q13)]]
|[[t(14;19)(q32;q13)]]
|[[der(Y)t(Y;1)(q12;q12) ]]
|[[der(Y)t(Y;1)(q12;q12) ]]
|[[MDS]]
|[[MDS]]
|
|}
|}
|'''GENES'''
|'''GENES'''
|-
|-
|[[inv(3)(q21q26.2) ]]
|[[Translocation t(3;3)(q21;q26.2) and Inversion inv(3)(q21q26.2)|inv(3)(q21q26.2)]]
|[[MDS]],[[ AML]]
|[[MDS]],[[ AML]]
|[[RPN1-MECOM(EVI1)]]
|[[RPN1-MECOM(EVI1)]]
|[[inv(16)(p13.1q22)]]
|[[inv(16)(p13.1q22)]]
|[[AML M4Eo]]
|[[AML M4Eo]]
|[[MYH11]],[[ CBFB]]
|[[MYH11-CBFB]]
|}
|}
|-
|-
|[[i(11)(q10) ]]
|[[i(11)(q10) ]]
|[[AML M2]],[[AML M4]],[[ MDS]]
|[[AML]],[[AML]],[[ MDS]]
|
|
|-
|-
|[[i(17)(q10)]]
|[[i(17)(q10)]]
|[[MDS]],[[ MPD]],[[ AML]],[[ CML]],[[ B-ALL]],[[ CLL]],[[ Hodgkin and NHL]]
|[[MDS]],[[ MPD]],[[ AML]],[[ CML]],[[ B-ALL]],[[CLL]],[[ Hodgkin and NHL]]
|
|
|-
|-
|[[i(21)(q10)]]
|[[i(21)(q10)]]
|[[B-ALL]],[[ MDS]],[[ NHL]],[[ AML]],[[ CMML]]
|[[B-ALL]],[[ MDS]],[[ NHL]],[[AML]],[[ CMML]]
|
|
|-
|-
|[[idic(X)(q13)]]
|[[idic(X)(q13)]]
|[[AML M1]],[[ M2]],[[ M4]],[[ MDS]],[[ RARS]]
|[[AML]],[[MDS]],[[RARS]]
|[[XIST]]
|[[XIST]]
|}
|}
|[[t(X;14) and t(Y;14)]]
|[[t(X;14) and t(Y;14)]]
|[[B-ALL]]
|[[B-ALL]]
|[[IGH-CRLF2]]
|[[T(X;14) and t(Y;14)|IGH-CRLF2]]
|-
|-
|[[t(5;14)(q35;q32)]]
|[[t(5;14)(q35;q32)]]
|-
|-
|[[del(1)(p32p32)]]
|[[del(1)(p32p32)]]
|[[B-ALL]]
|[[T-ALL]]
|[[TAL1-STIL]]
|[[SIL(STIL)-TAL1]]
|}
|}
|-
|-
|[[del(3)(p13p21)]]
|[[del(3)(p13p21)]]
|
|
|-
|-
|[[del(3)(q21)]]
|[[del(3)(q21)]]
|[[del(6)(q21)]]
|[[del(6)(q21)]]
|[[CLL]],[[ atypical CLL]],[[ AML]],[[ childhood B-ALL]],[[ childhood T-ALL]],[[ adult ALL]],[[ MM]]
|[[CLL]],[[ atypical CLL]],[[ AML]],[[ childhood B-ALL]],[[ childhood T-ALL]],[[ adult ALL]],[[ MM]]
|
|-
|-
|[[del(7)(p15)]]
|[[del(7)(p15)]]
|
|
|-
|-
|[[del(7)(p13) ]]
|[[del(7)(p13) ]]
|[[AML]],[[ NHL]]
|[[AML]],[[ NHL]]
|
|-
|-
|[[del(7)(p13p15)]]
|[[del(7)(p13p15)]]
|
|
|-
|-
|[[del(7)(p11.2)]]
|[[del(7)(p11.2)]]
|[[B-ALL]],[[ AML]],[[ MDS]]
|[[B-ALL]],[[ AML]],[[ MDS]]
|
|-
|-
|[[del(7)(q11.2)]]
|[[del(7)(q11.2)]]
|[[B-ALL]],[[ AML]],[[ MDS]]
|[[B-ALL]],[[ AML]],[[ MDS]]
|
|-
|-
|[[del(7)(q22q34)]]
|[[del(7)(q22q34)]]
|[[AML]],[[ MDS]],[[ NHL]]
|[[AML]],[[ MDS]],[[ NHL]]
|
|-
|-
|[[del(7)(q32q34)]]
|[[del(7)(q32q34)]]
|[[AML]],[[ MDS]],[[ NHL]]
|[[AML]],[[ MDS]],[[ NHL]]
|
|-
|-
|[[del(7)(q32)]]
|[[del(7)(q32)]]
|[[AML]],[[ MDS]],[[ NHL]]
|[[AML]],[[ MDS]],[[ NHL]]
|
|-
|-
|[[del(8)(p21)]]
|[[del(8)(p21)]]
|
|
|-
|-
|[[del(8)(q22)]]
|[[del(8)(q22)]]
|
|
|-
|-
|[[del(9)(p13)]]
|[[del(9)(p13)]]
|[[B-ALL]],[[ NHL]],[[ pediatric B-ALL ]]
|[[B-ALL]],[[ NHL]],[[ pediatric B-ALL ]]
|
|-
|-
|[[del(9)(p13p22)]]
|[[del(9)(p13p22)]]
|[[B-ALL]]
|[[B-ALL]]
|
|-
|-
|[[del(9)(p21)]]
|[[del(9)(p21)]]
|[[B-ALL]],[[ AML]],[[ NHL]]
|[[B-ALL]],[[ AML]],[[ NHL]]
|
|-
|-
|[[del(9)(p22)]]
|[[del(9)(p22)]]
|[[B-ALL]]
|[[B-ALL]]
|
|-
|-
|[[del(9)(q13)]]
|[[del(9)(q13)]]
|[[AML M1]],[[ M2]],[[ M4]],[[ M6]]
|[[AML M1]],[[ M2]],[[ M4]],[[ M6]]
|
|-
|-
|[[del(9)(q13q22)]]
|[[del(9)(q13q22)]]
|[[AML]],[[ MDS]]
|[[AML]],[[ MDS]]
|
|-
|-
|[[del(10)(q24)]]
|[[del(10)(q24)]]
|
|
|-
|-
|[[del(11)(p11.2)]]
|[[del(11)(p11.2)]]
|[[NHL]]
|[[NHL]]
|
|-
|-
|[[del(11)(p12p13)]]
|[[del(11)(p12p13)]]
|-
|-
|[[del(11)(q13)]]
|[[del(11)(q13)]]
|Missing
|
|
|-
|-
|[[del(11)(q13q21)]]
|[[del(11)(q13q21)]]
|Missing
|
|
|-
|-
|[[del(11)(q13q23)]]
|[[del(11)(q13q23)]]
|[[del(13)(q12q14)]]
|[[del(13)(q12q14)]]
|[[AML]],[[ AMM]],[[ MDS]],[[ NHL]]
|[[AML]],[[ AMM]],[[ MDS]],[[ NHL]]
|
|-
|-
|[[del(13)(q12q22)]]
|[[del(13)(q12q22)]]
|[[AML]],[[ PMF]],[[ CLL]],[[ MM]],[[ MDS]],[[ NHL]]
|[[AML]],[[ PMF]],[[ CLL]],[[ MM]],[[ MDS]],[[ NHL]]
|
|-
|-
|[[del(14)(q24) ]]
|[[del(14)(q24) ]]
|[[NHL]]
|[[NHL]]
|
|-
|-
|[[del(16)(q22)]]
|[[del(16)(q22)]]
|[[AML]],[[ AML-M4Eo]],[[ NHL]]
|[[AML]],[[AML-M4Eo]],[[ NHL]]
|
|-
|-
|[[del(17)(p11.2)]]
|[[del(17)(p11.2)]]
|[[del(18)(q21)]]
|[[del(18)(q21)]]
|[[AML]],[[ NHL]]
|[[AML]],[[ NHL]]
|
|-
|[[del(20)(q11.2q13.1)]]
|
|
|-
|-
|[[del(20)(q11.2q13.1)
|[[del(20)(q11.2q13.3)]]
del(20)(q11.2q13.3)]]
|[[AML]],[[MDS]],[[MPD]]
|[[AML]],[[ MDS]],[[ MPD]]
|
|-
|-
|[[ider(20)(p11.1)del(20)(q11.2q13.3)]]
|[[ider(20)(p11.1)del(20)(q11.2q13.3)]]
|[[AML]],[[ MDS]],[[ MPD]]
|[[AML]],[[ MDS]],[[ MPD]]
|[["
|
|-
|-
|[[del(X)(q24)]]
|[[del(X)(q24)]]
|[[NHL]]
|[[NHL]]
|
|}
|}
|'''ANOMALY'''
|'''ANOMALY'''
|'''ASSOCIATED DISORDERS with FISH test'''
|'''ASSOCIATED DISORDERS with FISH test'''
|-
|-
|[[+3]]
|[[+3]]
|-
|-
|[[+15]]
|[[+15]]
|Age related when sole anomaly or with -Y
|[[Age Related]] when sole anomaly or with [[-Y]]
|-
|-
|[[+19]]
|[[+19]]
|[[AML-M4eo]]
|[[AML-M4eo]]
|-
|-
|[[-7 A B]]
|[[-7]]
|[[MDS]],[[ RAEB/RAEB±T]],[[ CMML]],[[ J-CML]],[[ AML most often M4 or M6.]]
|[[MDS]],[[RAEB/RAEB±T]],[[CMML]],[[J-CML]],[[AML most often M4 or M6.]]
|-
|-
|[[-Y ]]
|[[-Y ]]
|age related when sole anomaly
|[[Age Related]] when sole anomaly
|}
|}
|[[t(8;14)(q11;q32)]]
|[[t(8;14)(q11;q32)]]
|[[B-ALL]]
|[[B-ALL]]
|[[CEBPD-IGH]]
|[[IGH-CEBPB]]
|-
|-
|[[i(9)(q10)/idic(9)(q10)]]
|[[i(9)(q10)/idic(9)(q10)]]
|[[B-ALL]]
|[[B-ALL]]
|
|-
|-
|[[dic(9;12)(p11;p11.2)]]
|[[dic(9;12)(p11;p11.2)]]
|[[B-ALL]]
|[[B-ALL]]
|
|-
|-
|[[dic(9;20)(p11;q11)]]
|[[dic(9;20)(p11;q11)]]
|[[T-ALL]]
|[[T-ALL]]
|[[LMO2(Rhom2)-TRA]]
|[[LMO2(Rhom2)-TRA]]
|}
|}