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BRST5:Tall Cell Carcinoma with Reversed Polarity (view source)
Revision as of 13:24, 29 February 2024
, 13:24, 29 February 2024Jennelleh moved page Tall Cell Carcinoma with Reversed Polarity to BRST5:Tall Cell Carcinoma with Reversed Polarity without leaving a redirect: Move to namespace BRST5
==Cancer Sub-Classification / Subtype==
==Cancer Sub-Classification / Subtype==
Tall cell carcinoma with reverse polarity
Tall cell carcinoma with reversed polarity
==Definition / Description of Disease==
==Definition / Description of Disease==
Tall cell carcinoma with reverse polarity is a rare variant of invasive breast carcinoma with unusual histopathologic features. In 2019, 5th edition of the World Health Organization (WHO) classification of breast tumors, it is in the group of rare and salivary gland-type tumors and is associated with favorable prognosis.
Tall cell carcinoma with reversed polarity is a rare variant of invasive breast carcinoma with unusual histopathologic features. In 2019, 5th edition of the World Health Organization (WHO) classification of breast tumors, it is in the group of rare and salivary gland-type tumors and is associated with favorable prognosis.
==Synonyms / Terminology==
==Synonyms / Terminology==
*Occasionally true papillae and cyst-like structures with colloid-like material are identified.
*Occasionally true papillae and cyst-like structures with colloid-like material are identified.
*Epithelial cells are tall, may have nuclear grooves and intranuclear cytoplasmic inclusions.
*Epithelial cells are tall, may have nuclear grooves and intranuclear cytoplasmic inclusions.
*The most characteristic feature is the presence of nuclei in the apical rather than basal pole of the cells hence the “reverse polarity”.[[File:Tall Cell Carcinoma with Reversed Polarity Evin G picture Aug 2023.jpg|none|thumb|600x600px|Breast tissue specimen containing tall cell carcinoma with reversed polarity. This tumor features solid nests of tumor cells with fibrovascular cores including foamy histiocytes (H&E stain, original magnification x20). Courtesy of H. Evin Gulbahce, University of Utah.]]<br />
*The most characteristic feature is the presence of nuclei in the apical rather than basal pole of the cells hence the “reverse polarity.”
==Immunophenotype==
==Immunophenotype==