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HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli (view source)
Revision as of 14:40, 13 December 2023
, 14:40, 13 December 2023no edit summary
{{Under Construction}}
{{Under Construction}}
<blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023-11-30. The original page can be found at [[HAEM4:Hairy Cell Leukemia Variant]].
<blockquote class='blockedit'>{{Box-round|title=HAEM5 Conversion Notes|This page was converted to the new template on 2023-12-07. The original page can be found at [[HAEM4:Hairy Cell Leukemia Variant]].
Note: consider content on the overview page: Splenic B-cell Lymphoma/Leukemia, Unclassifiable
Note: consider content on the overview page: Splenic B-cell Lymphoma/Leukemia, Unclassifiable
}}</blockquote>
}}</blockquote>
<span style="color:#0070C0">(General Instructions – The main focus of these pages is the clinically significant genetic alterations in each disease type. Use [https://www.genenames.org/ <u>HUGO-approved gene names and symbols</u>] (italicized when appropriate), [https://varnomen.hgvs.org/ HGVS-based nomenclature for variants], as well as generic names of drugs and testing platforms or assays if applicable. Please complete tables whenever possible and do not delete them (add N/A if not applicable in the table and delete the examples). Please do not delete or alter the section headings. The use of bullet points alongside short blocks of text rather than only large paragraphs is encouraged. Additional instructions below in italicized blue text should not be included in the final page content. Please also see </span><u>[[Author_Instructions]]</u><span style="color:#0070C0"> and [[Frequently Asked Questions (FAQs)|<u>FAQs</u>]] as well as contact your [[Leadership|<u>Associate Editor</u>]] or [mailto:CCGA@cancergenomics.org <u>Technical Support</u>])</span>
==Primary Author(s)*==
==Primary Author(s)*==
==Cancer Category / Type==
==Cancer Category / Type==
*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
*[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
==Cancer Sub-Classification / Subtype==
==Cancer Sub-Classification / Subtype==
*HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults
*HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults
*Name derives from clinicopathologic similarity to [[Hairy Cell Leukemia|hairy cell leukemia]] (HCL) but with important differences
*Name derives from clinicopathologic similarity to [[HAEM5:Hairy cell leukaemia|hairy cell leukemia]] (HCL) but with important differences
*Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections
*Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections
*Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL)
*Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL)
|Positive||CD11c, CD72, CD103
|Positive||CD11c, CD72, CD103
|-
|-
|Negative ([[Hairy Cell Leukemia|HCL]] markers)||CD25, CD123, annexin A1, TRAP, BRAF V600E
|Negative ([[HAEM5:Hairy cell leukaemia|HCL]] markers)||CD25, CD123, annexin A1, TRAP, BRAF V600E
|-
|-
|Negative
|Negative
==Links==
==Links==
*[[Hairy Cell Leukemia]]
*[[HAEM5:Hairy cell leukaemia]]
*[[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]
*[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]
==References==
==References==