Compendium of Cancer Genome Aberrations

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{{Under Construction}}
   
==Primary Author(s)*==
 
==Primary Author(s)*==
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==Cancer Category/Type==
 
==Cancer Category/Type==
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[[Angioimmunoblastic T-cell Lymphoma and Other Nodal Lymphomas of T Follicular Helper Cell Origin]]
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[[HAEM4:Angioimmunoblastic T-cell Lymphoma and Other Nodal Lymphomas of T Follicular Helper Cell Origin]]
    
==Cancer Sub-Classification / Subtype==
 
==Cancer Sub-Classification / Subtype==
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==Epidemiology / Prevalence==
 
==Epidemiology / Prevalence==
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*Occurs in middle-aged and elderly individuals
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*Occurs in middle-aged and elderly individuals<ref name=":0">{{Cite journal|last=L|first=de Leval|last2=C|first2=Gisselbrecht|last3=P|first3=Gaulard|date=2010|title=Advances in the understanding and management of angioimmunoblastic T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/19961485/|language=en|pmid=19961485}}</ref>
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*Males >> Females
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*Males >> Females<ref name=":0" />
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*One of the most common specific subtypes of PTCL
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*One of the most common specific subtypes of PTCL<ref>{{Cite journal|last=M|first=Vences|last2=Jm|first2=Guayasamin|last3=A|first3=Miralles|last4=I|first4=De la Riva|date=2013|title=To name or not to name: Criteria to promote economy of change in Linnaean classification schemes|url=https://pubmed.ncbi.nlm.nih.gov/26042291/|language=en|pmid=26042291}}</ref><ref>{{Cite journal|last=T|first=Rüdiger|last2=Dd|first2=Weisenburger|last3=Jr|first3=Anderson|last4=Jo|first4=Armitage|last5=J|first5=Diebold|last6=Ka|first6=MacLennan|last7=Bn|first7=Nathwani|last8=F|first8=Ullrich|last9=Hk|first9=Müller-Hermelink|date=2002|title=Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin's Lymphoma Classification Project|url=https://pubmed.ncbi.nlm.nih.gov/11863096/|language=en|pmid=11863096}}</ref><ref>{{Cite journal|last=J|first=Vose|last2=J|first2=Armitage|last3=D|first3=Weisenburger|date=2008|title=International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes|url=https://pubmed.ncbi.nlm.nih.gov/18626005/|language=en|pmid=18626005}}</ref>
 
**15-30% of non-cutaneous T-cell lymphomas
 
**15-30% of non-cutaneous T-cell lymphomas
 
**1-2% of all non-Hodgkin lymphomas
 
**1-2% of all non-Hodgkin lymphomas
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==Clinical Features<small><ref>{{Cite journal|last=F|first=Lachenal|last2=F|first2=Berger|last3=H|first3=Ghesquières|last4=P|first4=Biron|last5=A|first5=Hot|last6=E|first6=Callet-Bauchu|last7=C|first7=Chassagne|last8=B|first8=Coiffier|last9=I|first9=Durieu|date=2007|title=Angioimmunoblastic T-cell lymphoma: clinical and laboratory features at diagnosis in 77 patients|url=https://pubmed.ncbi.nlm.nih.gov/17873758/|language=en|pmid=17873758}}</ref><ref>{{Cite journal|last=N|first=Mourad|last2=N|first2=Mounier|last3=J|first3=Brière|last4=E|first4=Raffoux|last5=A|first5=Delmer|last6=A|first6=Feller|last7=Cj|first7=Meijer|last8=Jf|first8=Emile|last9=R|first9=Bouabdallah|date=2008|title=Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials|url=https://pubmed.ncbi.nlm.nih.gov/18292286/|language=en|doi=10.1182/blood-2007-08-105759|pmc=PMC2343588|pmid=18292286}}</ref><ref>{{Cite journal|last=W|first=Siegert|last2=C|first2=Nerl|last3=A|first3=Agthe|last4=M|first4=Engelhard|last5=G|first5=Brittinger|last6=M|first6=Tiemann|last7=K|first7=Lennert|last8=D|first8=Huhn|date=1995|title=Angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma: prognostic impact of clinical observations and laboratory findings at presentation. The Kiel Lymphoma Study Group|url=https://pubmed.ncbi.nlm.nih.gov/8664186/|language=en|pmid=8664186}}</ref></small>==
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==Clinical Features<small><ref>{{Cite journal|last=A|first=Dogan|last2=Ad|first2=Attygalle|last3=C|first3=Kyriakou|date=2003|title=Angioimmunoblastic T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/12780782/|language=en|pmid=12780782}}</ref><ref>{{Cite journal|last=F|first=Lachenal|last2=F|first2=Berger|last3=H|first3=Ghesquières|last4=P|first4=Biron|last5=A|first5=Hot|last6=E|first6=Callet-Bauchu|last7=C|first7=Chassagne|last8=B|first8=Coiffier|last9=I|first9=Durieu|date=2007|title=Angioimmunoblastic T-cell lymphoma: clinical and laboratory features at diagnosis in 77 patients|url=https://pubmed.ncbi.nlm.nih.gov/17873758/|language=en|pmid=17873758}}</ref><ref>{{Cite journal|last=N|first=Mourad|last2=N|first2=Mounier|last3=J|first3=Brière|last4=E|first4=Raffoux|last5=A|first5=Delmer|last6=A|first6=Feller|last7=Cj|first7=Meijer|last8=Jf|first8=Emile|last9=R|first9=Bouabdallah|date=2008|title=Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials|url=https://pubmed.ncbi.nlm.nih.gov/18292286/|language=en|doi=10.1182/blood-2007-08-105759|pmc=PMC2343588|pmid=18292286}}</ref><ref>{{Cite journal|last=W|first=Siegert|last2=C|first2=Nerl|last3=A|first3=Agthe|last4=M|first4=Engelhard|last5=G|first5=Brittinger|last6=M|first6=Tiemann|last7=K|first7=Lennert|last8=D|first8=Huhn|date=1995|title=Angioimmunoblastic lymphadenopathy (AILD)-type T-cell lymphoma: prognostic impact of clinical observations and laboratory findings at presentation. The Kiel Lymphoma Study Group|url=https://pubmed.ncbi.nlm.nih.gov/8664186/|language=en|pmid=8664186}}</ref></small>==
 
'''Sign and Symptoms'''
 
'''Sign and Symptoms'''
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==Chromosomal Rearrangements (Gene Fusions)==
 
==Chromosomal Rearrangements (Gene Fusions)==
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{| class="wikitable sortable"
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|-
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!Chromosomal Rearrangement!!Genes in Fusion (5’ or 3’ Segments)!!Pathogenic Derivative!!Reference
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|-
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|t(5;9)(q33;q22)||''ITK'' / ''SYK''||der(5); der(9)||<ref>{{Cite journal|last=B|first=Streubel|last2=U|first2=Vinatzer|last3=M|first3=Willheim|last4=M|first4=Raderer|last5=A|first5=Chott|date=2006|title=Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/16341044/|language=en|pmid=16341044}}</ref><ref name=":4">{{Cite journal|last=M|first=Wang|last2=S|first2=Zhang|last3=Ss|first3=Chuang|last4=M|first4=Ashton-Key|last5=E|first5=Ochoa|last6=N|first6=Bolli|last7=G|first7=Vassiliou|last8=Z|first8=Gao|last9=Mq|first9=Du|date=2017|title=Angioimmunoblastic T cell lymphoma: novel molecular insights by mutation profiling|url=https://pubmed.ncbi.nlm.nih.gov/28148900/|language=en|doi=10.18632/oncotarget.14846|pmc=PMC5392284|pmid=28148900}}</ref>
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|-
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|t(7;14)(q35;q32.1)
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|''TRB/TCL1A''
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|der(7); der(14)
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|<ref>{{Cite journal|last=Mf|first=Cosimi|last2=I|first2=Casagranda|last3=G|first3=Ghiazza|last4=G|first4=Rossi|last5=P|first5=Galvani|date=1990|title=Rearrangements on chromosomes 7 and 14 with breakpoints at 7q35 and 14q11 in angioimmunoblastic lymphadenopathy and IBL-like T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/2284141/|language=en|pmid=2284141}}</ref>
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|-
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|t(14;14)(q11;q32.1) / inv(14)(q11q32.1)
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|''TRA-TRD/TCL1A''
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|der(14)
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|<ref>{{Cite journal|last=B|first=Schlegelberger|last2=A|first2=Feller|last3=A|first3=Himmler|last4=W|first4=Grote|date=1990|title=Inv(14)(q11q32) in one of four different clones in a case of angioimmunoblastic lymphadenopathy|url=https://pubmed.ncbi.nlm.nih.gov/2293883/|language=en|pmid=2293883}}</ref><ref>{{Cite journal|last=E|first=Leich|last2=E|first2=Haralambieva|last3=A|first3=Zettl|last4=A|first4=Chott|last5=T|first5=Rüdiger|last6=S|first6=Höller|last7=Hk|first7=Müller-Hermelink|last8=G|first8=Ott|last9=A|first9=Rosenwald|date=2007|title=Tissue microarray-based screening for chromosomal breakpoints affecting the T-cell receptor gene loci in mature T-cell lymphomas|url=https://pubmed.ncbi.nlm.nih.gov/17582237/|language=en|pmid=17582237}}</ref>
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|-
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|chr(2)(q33.2)
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|''CTLA4/CD28''
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|der(2)
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|<ref>{{Cite journal|last=Hy|first=Yoo|last2=P|first2=Kim|last3=Ws|first3=Kim|last4=Sh|first4=Lee|last5=S|first5=Kim|last6=Sy|first6=Kang|last7=Hy|first7=Jang|last8=Je|first8=Lee|last9=J|first9=Kim|date=2016|title=Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/26819049/|language=en|doi=10.3324/haematol.2015.139253|pmc=PMC5013939|pmid=26819049}}</ref>
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|}
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==Characteristic Chromosomal Aberrations / Patterns==
 
==Characteristic Chromosomal Aberrations / Patterns==
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==Links==
 
==Links==
   −
[[Angioimmunoblastic T-cell Lymphoma and Other Nodal Lymphomas of T Follicular Helper Cell Origin]]
+
[[HAEM4:Angioimmunoblastic T-cell Lymphoma and Other Nodal Lymphomas of T Follicular Helper Cell Origin]]
    
==References==
 
==References==
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