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HAEM4:Hairy Cell Leukemia Variant (view source)
Revision as of 16:33, 4 December 2023
, 16:33, 4 December 2023no edit summary
==Cancer Category/Type==
==Cancer Category/Type==
*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
*[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
==Cancer Sub-Classification / Subtype==
==Cancer Sub-Classification / Subtype==
*HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults
*HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults
*Name derives from clinicopathologic similarity to [[Hairy Cell Leukemia|hairy cell leukemia]] (HCL) but with important differences
*Name derives from clinicopathologic similarity to [[HAEM5:Hairy cell leukaemia|hairy cell leukemia]] (HCL) but with important differences
*Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections
*Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections
*Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL)
*Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL)
|Positive||CD11c, CD72, CD103
|Positive||CD11c, CD72, CD103
|-
|-
|Negative ([[Hairy Cell Leukemia|HCL]] markers)||CD25, CD123, annexin A1, TRAP, BRAF V600E
|Negative ([[HAEM5:Hairy cell leukaemia|HCL]] markers)||CD25, CD123, annexin A1, TRAP, BRAF V600E
|-
|-
|Negative
|Negative
==Links==
==Links==
*[[Hairy Cell Leukemia]]
*[[HAEM5:Hairy cell leukaemia]]
*[[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]
*[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]
==References==
==References==