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HAEM4:Hairy Cell Leukemia Variant (view source)
Revision as of 16:33, 4 December 2023
, 16:33, 4 December 2023no edit summary
{{DISPLAYTITLE:Hairy Cell Leukemia Variant}}
<blockquote class='blockedit'>{{Box-round|title=PREVIOUS EDITION|This page from the 4th edition of Haematolymphoid Tumours is being updated. See 5th edition [[HAEM5:Table_of_Contents|Table of Contents]].
}}</blockquote>
==Primary Author(s)*==
==Primary Author(s)*==
==Cancer Category/Type==
==Cancer Category/Type==
*[[Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
*[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]
==Cancer Sub-Classification / Subtype==
==Cancer Sub-Classification / Subtype==
*HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults
*HCLv is a rare chronic neoplasm of B-cell origin seen mostly in adults
*Name derives from clinicopathologic similarity to [[Hairy Cell Leukemia|hairy cell leukemia]] (HCL) but with important differences
*Name derives from clinicopathologic similarity to [[HAEM5:Hairy cell leukaemia|hairy cell leukemia]] (HCL) but with important differences
*Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections
*Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections
*Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL)
*Most respond poorly to monotherapy with a purine analog or interferon alpha (used for HCL)
|Positive||CD11c, CD72, CD103
|Positive||CD11c, CD72, CD103
|-
|-
|Negative ([[Hairy Cell Leukemia|HCL]] markers)||CD25, CD123, annexin A1, TRAP, BRAF V600E
|Negative ([[HAEM5:Hairy cell leukaemia|HCL]] markers)||CD25, CD123, annexin A1, TRAP, BRAF V600E
|-
|-
|Negative
|Negative
==Links==
==Links==
*[[Hairy Cell Leukemia]]
*[[HAEM5:Hairy cell leukaemia]]
*[[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]
*[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]
==References==
==References==
==Notes==
==Notes==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.
[[Category:HAEM4]] [[Category:DISEASE]]