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HAEM4:Hairy Cell Leukemia (view source)
Revision as of 16:33, 4 December 2023
, 16:33, 4 December 2023no edit summary
==Cancer Category/Type==
==Cancer Category/Type==
*[[Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]
*[[HAEM4:Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]
==Cancer Sub-Classification / Subtype==
==Cancer Sub-Classification / Subtype==
<sup>‡</sup>Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal] and [https://cancer.sanger.ac.uk/cosmic COSMIC].
<sup>‡</sup>Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal] and [https://cancer.sanger.ac.uk/cosmic COSMIC].
'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain. These seem to be more similar molecularly and clinically to [[Hairy Cell Leukemia Variant|HCLv]].
'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain. These seem to be more similar molecularly and clinically to [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]].
*BRAF and MAP2K1 activating mutations are mutually exclusive
*BRAF and MAP2K1 activating mutations are mutually exclusive
|BRAF p.Val600Glu
|BRAF p.Val600Glu
|Diagnostic
|Diagnostic
|May be useful when immunophenotype is equivocal; Excludes [[Hairy Cell Leukemia Variant|HCLv]]
|May be useful when immunophenotype is equivocal; Excludes [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]]
|-
|-
|MAP2K1
|MAP2K1
==Links==
==Links==
*[[Hairy Cell Leukemia Variant]]
*[[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli]]
*[[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]
*[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]
==References==
==References==