Changes

==Primary Author(s)*==

==Primary Author(s)*==

==Cancer Category/Type==

==Cancer Category/Type==

*[[Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]

*[[HAEM4:Mature B-Cell Neoplasms|Mature B-Cell Neoplasm]]

==Cancer Sub-Classification / Subtype==

==Cancer Sub-Classification / Subtype==

^‡Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal] and [https://cancer.sanger.ac.uk/cosmic COSMIC].

^‡Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal] and [https://cancer.sanger.ac.uk/cosmic COSMIC].

'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain.  These seem to be more similar molecularly and clinically to [[Hairy Cell Leukemia Variant|HCLv]].

'''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain.  These seem to be more similar molecularly and clinically to [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]].

*BRAF and MAP2K1 activating mutations are mutually exclusive

*BRAF and MAP2K1 activating mutations are mutually exclusive

|BRAF p.Val600Glu

|BRAF p.Val600Glu

|Diagnostic

|Diagnostic

|May be useful when immunophenotype is equivocal; Excludes [[Hairy Cell Leukemia Variant|HCLv]]

|May be useful when immunophenotype is equivocal; Excludes [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]]

|-

|-

|MAP2K1

|MAP2K1

==Links==

==Links==

*[[Hairy Cell Leukemia Variant]]

*[[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli]]

*[[Splenic Diffuse Red Pulp Small B-cell Lymphoma]]

*[[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]

==References==

==References==

==Notes==

==Notes==

<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.

<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.