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==~~Myeloid proliferations and neoplasms~~==

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==Myeloproliferative Neoplasms (MPN) ([[HAEM4:Myeloproliferative Neoplasms (MPN)|Overview Page Link]])==

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~~'''~~Myeloid ~~precursor lesions'''~~

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*[[HAEM4:Chronic Myeloid Leukemia (CML), BCR-ABL1 Positive]]

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~~''Clonal Haematopoiesis''~~

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*[[HAEM4:Chronic Neutrophilic Leukemia (CNL)]]

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- [[HAEM4:~~Clonal haematopoiesis~~]]

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*[[HAEM4:Polycythemia Vera (PV)]]

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- [[HAEM4:~~Clonal cytopenias of undetermined significance~~]]

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*[[HAEM4:Primary Myelofibrosis (PMF)]]

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*[[HAEM4:Essential Thrombocythemia (ET)]]

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*[[HAEM4:Chronic Eosinophilic Leukemia, Not Otherwise Specified]]

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*[[HAEM4:Myeloproliferative Neoplasm (MPN), Unclassifiable]]

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~~'''Myeloproliferative neoplasms~~

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==Mastocytosis ([[HAEM4:Mastocytosis|Overview Page Link]])==

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~~''Myeloproliferative neoplasms''~~

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- [[HAEM4:~~Chronic myeloid leukaemia]]~~

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~~- [[HAEM4:Chronic neutrophilic leukaemia]]~~

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~~- [[HAEM4:Chronic eosinophilic leukaemia]]~~

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~~- [[HAEM4:Polycythaemia vera]]~~

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~~- [[HAEM4:Essential thrombocythaemia]]~~

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~~- [[HAEM4:Primary myelofibrosis]]~~

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~~- [[HAEM4:Juvenile myelomonocytic leukaemia]]~~

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~~- [[HAEM4:Myeloproliferative neoplasm, NOS~~]]

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~~'''Mastocytosis'''~~

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*[[HAEM4:Cutaneous Mastocytosis]]

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- [[HAEM4:Cutaneous ~~mastocytosis~~]]

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*[[HAEM4:Systemic Mastocytosis]]

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- [[HAEM4:Systemic ~~mastocytosis~~]]

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*[[HAEM4:Mast Cell Sarcoma]]

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- [[HAEM4:Mast ~~cell sarcoma~~]]

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~~'''Myelodysplastic neoplasms'''~~

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==Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB or FGFR1, or with PCM1-JAK2 ([[HAEM4:Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB or FGFR1, or with PCM1-JAK2|Overview Page Link]])==

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~~''Myelodysplastic neoplasms~~, with ~~defining genetic abnormalities''~~

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- [[HAEM4:~~Myelodysplastic neoplasm~~ with ~~low blasts~~ and ~~5q deletion]]~~

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~~- [[HAEM4:Myelodysplastic neoplasm with low blasts and SF3B1 mutation]]~~

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~~- [[HAEM4:Myelodysplastic neoplasm with biallelic TP53 inactivation]]~~

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~~''Myelodysplastic neoplasms~~, ~~morphologically defined''~~

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~~- [[HAEM4:Myelodysplastic neoplasm with low blasts]]~~

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~~- [[HAEM4:Myelodysplastic neoplasm~~, ~~hypoplastic]]~~

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~~- [[HAEM4:Myelodysplastic neoplasm with increased blasts]]~~

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~~''Myelodysplastic neoplasms of childhood''~~

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~~- [[HAEM4:Childhood myelodysplastic neoplasm~~ with ~~low blasts]]~~

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- ~~[[HAEM4:Childhood myelodysplastic neoplasm with increased blasts~~]]

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~~'''Myelodysplastic/myeloproliferative neoplasms'''~~

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*[[HAEM4:Myeloid/Lymphoid Neoplasms with PDGFRA Rearrangement]]

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- [[HAEM4:~~Chronic myelomonocytic leukaemia~~]]

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*[[HAEM4:Myeloid/Lymphoid Neoplasms with PDGFRB Rearrangement]]

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- [[HAEM4:~~Myelodysplastic~~/~~myeloproliferative neoplasm~~ with ~~neutrophilia~~]]

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*[[HAEM4:Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement]]

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- [[HAEM4:~~Myelodysplastic~~/~~myeloproliferative neoplasm~~ with ~~SF3B1 mutation and thrombocytosis~~]]

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*[[HAEM4:Myeloid/Lymphoid Neoplasms with PCM1-JAK2]]

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- [[HAEM4:~~Myelodysplastic~~/~~myeloproliferative neoplasm, NOS~~]]

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~~'''Acute myeloid leukaemia'''~~

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==Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) ([[HAEM4:Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN)|Overview Page Link]])==

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~~''Acute myeloid leukaemia with defining genetic abnormalities''~~

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- [[HAEM4:~~Acute promyelocytic leukaemia with PML::RARA fusion]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with RUNX1::RUNX1T1 fusion]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with CBFB::MYH11 fusion]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with DEK::NUP214 fusion]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with RBM15::MRTFA fusion]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with BCR::ABL1 fusion]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with KMT2A rearrangement]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with MECOM rearrangement]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with NUP98 rearrangement]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with NPM1 mutation]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with CEBPA mutation]]~~

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~~- [[HAEM4:Acute myeloid leukaemia, myelodysplasia-related]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with other defined genetic alterations]]~~

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~~''Acute myeloid leukaemia, defined by differentiation''~~

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~~- [[HAEM4:Acute myeloid leukaemia with minimal differentiation]]~~

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~~- [[HAEM4:Acute myeloid leukaemia without maturation]]~~

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~~- [[HAEM4:Acute myeloid leukaemia with maturation]]~~

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~~- [[HAEM4:Acute basophilic leukaemia]]~~

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~~- [[HAEM4:Acute myelomonocytic leukaemia]]~~

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~~- [[HAEM4:Acute monocytic leukaemia]]~~

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~~- [[HAEM4:Acute erythroid leukaemia]]~~

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~~- [[HAEM4:Acute megakaryoblastic leukaemia]]~~

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~~''Myeloid sarcoma''~~

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~~- [[HAEM4:Myeloid sarcoma~~]]

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~~'''~~Myeloid ~~neoplasms~~, ~~secondary'''~~

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*[[HAEM4:Chronic Myelomonocytic Leukemia (CMML)]]

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~~''Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions''~~

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*[[HAEM4:Atypical Chronic Myeloid Leukemia (aCML), BCR-ABL1 Negative]]

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- [[HAEM4:~~Myeloid neoplasm post cytotoxic therapy~~]]

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*[[HAEM4:Juvenile Myelomonocytic Leukemia (JMML)]]

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- [[HAEM4:~~Myeloid neoplasms associated~~ with ~~germline predisposition~~]]

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*[[HAEM4:Myelodysplastic/Myeloproliferative Neoplasms with Ring Sideroblasts and Thrombocytosis (MDS/MPN-RS-T)|MDS/MPN with Ring Sideroblasts and Thrombocytosis (MDS/MPN-RS-T)]]

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- [[HAEM4:~~Myeloid proliferations associated with Down syndrome~~]]

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*[[HAEM4:Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN), Unclassifiable|MDS/MPN, Unclassifiable]]

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~~'''Myeloid/lymphoid neoplasms'''~~

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==Myelodysplastic Syndromes (MDS) ([[HAEM4:Myelodysplastic Syndromes (MDS)|Overview Page Link]])==

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~~''Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement''~~

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- [[HAEM4:~~Myeloid/lymphoid neoplasm with PDGFRA rearrangement]]~~

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~~- [[HAEM4:Myeloid/lymphoid neoplasm with PDGFRB rearrangement]]~~

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~~- [[HAEM4:Myeloid/lymphoid neoplasm with FGFR1 rearrangement]]~~

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~~- [[HAEM4:Myeloid/lymphoid neoplasm with JAK2 rearrangement]]~~

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~~- [[HAEM4:Myeloid/lymphoid neoplasm with FLT3 rearrangement]]~~

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~~- [[HAEM4:Myeloid/lymphoid neoplasm with ETV6::ABL1 fusion]]~~

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~~- [[HAEM4:Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes~~]]

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~~'''Acute leukaemias of mixed or ambiguous lineage'''~~

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*[[HAEM4:Myelodysplastic Syndrome (MDS) with Single Lineage Dysplasia|MDS with Single Lineage Dysplasia]]

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~~''Acute leukaemia of ambiguous lineage with defining genetic abnormalities''~~

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*[[HAEM4:Myelodysplastic Syndrome with Ring Sideroblasts (MDS-RS)|MDS with Ring Sideroblasts (MDS-RS)]]

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- [[HAEM4:~~Mixed-phenotype acute leukaemia~~ with ~~BCR::ABL1 fusion~~]]

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*[[HAEM4:Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia|MDS with Ring Sideroblasts and Multilineage Dysplasia]]

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- [[HAEM4:~~Mixed~~-~~phenotype acute leukaemia~~ with ~~KMT2A rearrangement~~]]

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*[[HAEM4:Myelodysplastic Syndrome (MDS) with Multilineage Dysplasia|MDS with Multilineage Dysplasia]]

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- [[HAEM4:~~Acute leukaemia of ambiguous lineage~~ with ~~other defined genetic alterations~~ ]]

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*[[HAEM4:Myelodysplastic Syndrome (MDS) with Excess Blasts|MDS with Excess Blasts]]

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~~''Acute leukaemia of ambiguous lineage, immunophenotypically defined''~~

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*[[HAEM4:Myelodysplastic Syndrome (MDS) with Isolated del(5q)|MDS with Isolated del(5q)]]

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- [[HAEM4:~~Mixed-phenotype acute leukaemia, B/myeloid~~]]

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*[[HAEM4:Myelodysplastic Syndrome (MDS), Unclassifiable|MDS, Unclassifiable]]

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- [[HAEM4:~~Mixed-phenotype acute leukaemia, T/myeloid~~]]

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*[[HAEM4:Refractory Cytopenia of Childhood]]

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- [[HAEM4:~~Mixed-phenotype acute leukaemia, rare types~~]]

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- [[HAEM4:~~Acute leukaemia of ambiguous lineage~~, ~~NOS~~]]

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- [[HAEM4:~~Acute undifferentiated leukaemia~~]]

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~~==Histiocytic/Dendritic cell neoplasms==~~

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~~'''Plasmacytoid dendritic cell neoplasms'''~~

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==Myeloid Neoplasms with Germline Predisposition ([[HAEM4:Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms|Overview Page Link]])==

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~~''Plasmacytoid dendritic cell neoplasms''~~

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~~- [[HAEM4:Mature plasmacytoid dendritic cell proliferation associated~~ with ~~myeloid neoplasm]]~~

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- [[HAEM4:~~Blastic plasmacytoid dendritic cell neoplasm~~]]

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~~'''Langerhans cell and other dendritic cell neoplasms'''~~

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*[[HAEM4:Acute Myeloid Leukaemia with Germline CEBPA Mutation]]

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~~''Langerhans cells neoplasms''~~

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*[[HAEM4:Myeloid Neoplasms with Germline DDX41 Mutation]]

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- [[HAEM4:~~Langerhans cell histiocytosis~~]]

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*[[HAEM4:Myeloid Neoplasms with Germline RUNX1 Mutation]]

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- [[HAEM4:~~Langerhans cell sarcoma~~]]

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*[[HAEM4:Myeloid Neoplasms with Germline ANKRD26 Mutation]]

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~~''Other dendritic cell neoplasms''~~

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*[[HAEM4:Myeloid Neoplasms with Germline ETV6 Mutation]]

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- [[HAEM4:~~Indeterminate dendritic cell tumour~~]]

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*[[HAEM4:Myeloid Neoplasms with Germline GATA2 Mutation]]

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- [[HAEM4:~~Interdigitating dendritic cell sarcoma~~]]

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~~'''Histiocyte/macrophage neoplasms'''~~

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==Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms ([[HAEM4:Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms|Overview Page Link]])==

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~~''Histiocytic neoplasms''~~

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- [[HAEM4:~~Juvenile xanthogranuloma]]~~

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~~- [[HAEM4:Erdheim-Chester disease]]~~

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~~- [[HAEM4:Rosai-Dorfman Disease~~]]

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~~- [[HAEM4:ALK-positive histiocytosis]]~~

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~~- [[HAEM4:Histiocytic sarcoma]]~~

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~~==B-cell lymphoid proliferations and lymphomas~~==

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~~'''Tumour like lesions with B-cell predominance'''~~

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*[[HAEM4:Acute Myeloid Leukemia (AML) with Recurrent Genetic Abnormalities|AML with Recurrent Genetic Abnormalities]]

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- [[HAEM4:~~Reactive B-cell rich lymphoid proliferations that can mimic lymphoma]]~~

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~~- [[HAEM4:IgG4-related disease]]~~

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~~- [[HAEM4:Unicentric Castleman disease]]~~

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~~- [[HAEM4:Idiopathic multicentric Castleman disease]]~~

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~~- [[HAEM4:KSHV/HHV8-associated multicentric Castleman disease~~]]

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~~'''Precursor B-cell neoplasms'''~~

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- [[HAEM4:Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1); RUNX1-RUNX1T1|AML with t(8;21)(q22;q22.1); RUNX1-RUNX1T1]]

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~~''B-lymphoblastic leukaemias/lymphomas''~~

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- [[HAEM4:Acute Myeloid Leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11|AML with with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11]]

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- [[HAEM4:B-~~lymphoblastic leukaemia/lymphoma~~]]

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- [[HAEM4:Acute Promyelocytic Leukemia (APL) with PML-RARA]]

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- [[HAEM4:B-~~lymphoblastic leukaemia/lymphoma~~ with ~~high hyperdiploidy~~]]

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- [[HAEM4:Acute Myeloid Leukemia (AML) with t(9;11)(p21.3;q23.3); KMT2A-MLLT3|AML with t(9;11)(p21.3;q23.3); KMT2A-MLLT3]]

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- [[HAEM4:B-~~lymphoblastic leukaemia/lymphoma with hypodiploidy~~]]

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- [[HAEM4:Acute Myeloid Leukemia (AML) with t(6;9)(p23;q34.1); DEK-NUP214|AML with t(6;9)(p23;q34.1); DEK-NUP214]]

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- [[HAEM4:B-~~lymphoblastic leukaemia/lymphoma~~ with ~~iAMP21~~]]

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- [[HAEM4:Acute Myeloid Leukemia (AML) with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);GATA2, MECOM|AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);GATA2, MECOM]]

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- [[HAEM4:~~B-lymphoblastic leukaemia/lymphoma~~ with ~~BCR::ABL1 fusion]]~~

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- [[HAEM4:Acute Myeloid Leukemia (AML) Megakaryoblastic with t(1;22)(p13.3;q13.1);RBM15-MKL1|AML Megakaryoblastic with t(1;22)(p13.3;q13.1);RBM15-MKL1]]

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~~- [[HAEM4:B~~-~~lymphoblastic leukaemia/lymphoma~~ with ~~BCR::ABL1~~-~~like features~~]]

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- [[HAEM4:Acute Myeloid Leukemia (AML) with BCR-ABL1|AML with BCR-ABL1]]

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- [[HAEM4:~~B lymphoblastic leukaemia/lymphoma~~ with ~~KMT2A rearrangement~~]]

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- [[HAEM4:Acute Myeloid Leukemia (AML) with Mutated NPM1|AML with Mutated NPM1]]

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- [[HAEM4:~~B lymphoblastic leukaemia/lymphoma~~ with ~~ETV6::RUNX1 fusion]]~~

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- [[HAEM4:Acute Myeloid Leukemia (AML) with Biallelic Mutations of CEBPA|AML with Biallelic Mutations of CEBPA]]

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~~- [[HAEM4:B~~-~~lymphoblastic leukaemia/lymphoma~~ with ~~ETV6::RUNX1~~-~~like features~~]]

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- [[HAEM4:Acute Myeloid Leukemia (AML) with Mutated RUNX1|AML with Mutated RUNX1]]

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- [[HAEM4:~~B lymphoblastic leukaemia/lymphoma~~ with ~~TCF3::PBX1 fusion]]~~

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- ~~[[HAEM4:B lymphoblastic leukaemia/lymphoma~~ with ~~IGH::IL3 fusion~~ ]]

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- [[HAEM4:~~B lymphoblastic leukaemia/lymphoma~~ with ~~TCF3::HLF fusion~~]]

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- [[HAEM4:~~B-lymphoblastic leukaemia/lymphoma~~ with ~~other defined genetic alterations~~]]

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- [[HAEM4:~~B-lymphoblastic leukaemia/lymphoma, NOS~~]]

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~~'''Mature B-cell neoplasms'''~~

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*[[HAEM4:Acute Myeloid Leukemia (AML) with Myelodysplasia-Related Changes|AML with Myelodysplasia-Related Changes]]

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~~''Pre-neoplastic and neoplastic small lymphocytic proliferations ''~~

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~~- [[HAEM4:Monoclonal B-cell lymphocytosis]]~~

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~~- [[HAEM4:Chronic lymphocytic leukaemia/small lymphocytic lymphoma]]~~

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~~''Splenic B-cell lymphomas and leukaemias''~~

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~~- [[HAEM4:Hairy cell leukaemia]]~~

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~~- [[HAEM4:Splenic marginal zone lymphoma]]~~

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~~- [[HAEM4:Splenic diffuse red pulp small B-cell lymphoma]]~~

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~~- [[HAEM4:Splenic B-cell lymphoma/leukaemia with prominent nucleoli]]~~

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~~''Lymphoplasmacytic lymphoma''~~

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~~- [[HAEM4:Lymphoplasmacytic lymphoma]]~~

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~~''Marginal zone lymphoma''~~

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~~- [[HAEM4:Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue]]~~

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~~- [[HAEM4:Primary cutaneous marginal zone lymphoma ]]~~

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~~- [[HAEM4:Nodal marginal zone lymphoma]]~~

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~~- [[HAEM4:Paediatric nodal marginal zone lymphoma]]~~

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~~''Follicular lymphoma''~~

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~~- [[HAEM4:In situ follicular B-cell neoplasm]]~~

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~~- [[HAEM4:Follicular lymphoma]]~~

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~~- [[HAEM4:Paediatric-type follicular lymphoma]]~~

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~~- [[HAEM4:Duodenal-type follicular lymphoma]]~~

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~~''Cutaneous follicle centre lymphoma''~~

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~~- [[HAEM4:Primary cutaneous follicle centre lymphoma]]~~

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~~''Mantle cell lymphoma''~~

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~~- [[HAEM4:In situ mantle cell neoplasm]]~~

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~~- [[HAEM4:Mantle cell lymphoma]]~~

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~~- [[HAEM4:Leukaemic non-nodal mantle cell lymphoma]]~~

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~~''Transformations of indolent B-cell lymphomas''~~

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~~- [[HAEM4:Transformations of indolent B-cell lymphomas]]~~

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~~''Large B-cell lymphomas''~~

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~~- [[HAEM4:Diffuse large B-cell lymphoma, NOS]]~~

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~~- [[HAEM4:T-cell/histiocyte-rich large B-cell lymphoma]]~~

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~~- [[HAEM4:Diffuse large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2 rearrangements]]~~

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~~- [[HAEM4:ALK-positive large B-cell lymphoma]]~~

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- [[HAEM4:~~Large B-cell lymphoma~~ with ~~IRF4 rearrangement]]~~

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~~- [[HAEM4:High grade B~~-~~cell lymphoma~~ with ~~11q aberrations]]~~

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~~- [[HAEM4:Lymphomatoid granulomatosis]]~~

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~~- [[HAEM4:EBV-positive diffuse large B-cell lymphoma]]~~

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~~- [[HAEM4:Diffuse large B-cell lymphoma associated with chronic inflammation]]~~

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~~- [[HAEM4:Fibrin-associated large B-cell lymphoma]]~~

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~~- [[HAEM4:Fluid overload-associated large B-cell lymphoma]]~~

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~~- [[HAEM4:Plasmablastic lymphoma]]~~

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~~- [[HAEM4:Primary large B-cell lymphoma of immune-privileged sites]]~~

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~~- [[HAEM4:Primary cutaneous diffuse large B-cell lymphoma, leg type]]~~

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~~- [[HAEM4:Intravascular large B-cell lymphoma]]~~

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~~- [[HAEM4:Primary mediastinal large B-cell lymphoma]]~~

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~~- [[HAEM4:Mediastinal grey zone lymphoma]]~~

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~~- [[HAEM4:High-grade B-cell lymphoma, NOS]]~~

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~~''Burkitt lymphoma''~~

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~~- [[HAEM4:Burkitt lymphoma]]~~

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~~''KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas''~~

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~~- [[HAEM4:Primary effusion lymphoma]]~~

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~~- [[HAEM4:KSHV/HHV8-positive diffuse large B-cell lymphoma]]~~

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~~- [[HAEM4:KSHV/HHV8-positive germinotropic lymphoproliferative disorder]]~~

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~~''Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation''~~

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~~- [[HAEM4:Hyperplasias arising in immune deficiency/dysregulation]]~~

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~~- [[HAEM4:Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation ]]~~

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~~- [[HAEM4:EBV-positive mucocutaneous ulcer]]~~

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~~- [[HAEM4:Lymphomas arising in immune deficiency / dysregulation ]]~~

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~~- [[HAEM4:Inborn error of immunity~~-~~associated lymphoid proliferations and lymphomas~~]]

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~~'''Hodgkin lymphoma'''~~

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*[[HAEM4:Therapy-Related Myeloid Neoplasms]]

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- [[HAEM4:~~Classic Hodgkin lymphoma ]]~~

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- ~~[[HAEM4:Nodular lymphocyte predominant Hodgkin lymphoma~~]]

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~~'''Plasma cell neoplasms and other diseases with paraproteins'''~~

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*[[HAEM4:Acute Myeloid Leukemia (AML), Not Otherwise Specified|AML, Not Otherwise Specified]]

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~~''Monoclonal gammopathies''~~

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- [[HAEM4:~~Cold agglutinin disease ]]~~

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~~- [[HAEM4:IgM monoclonal gammopathy of undetermined significance]]~~

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~~- [[HAEM4:Non-IgM monoclonal gammopathy of undetermined significance]]~~

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~~- [[HAEM4:Monoclonal gammopathy of renal significance]]~~

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~~''Diseases with monoclonal immunoglobulin deposition''~~

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~~- [[HAEM4:Immunoglobulin-related~~ (AL) ~~amyloidosis]]~~

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~~- [[HAEM4:Monoclonal immunoglobulin deposition disease]]~~

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~~''Heavy chain diseases''~~

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~~- [[HAEM4:Mu heavy chain disease]]~~

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~~- [[HAEM4:Gamma heavy chain disease]]~~

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~~- [[HAEM4:Alpha heavy chain disease]]~~

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~~''Plasma cell neoplasms''~~

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~~- [[HAEM4:Plasmacytoma]]~~

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~~- [[HAEM4:Plasma cell myeloma / multiple myeloma]]~~

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~~- [[HAEM4:Plasma cell neoplasms with associated paraneoplastic syndrome~~]]

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~~==T-cell and NK-cell lymphoid proliferations and lymphomas==~~

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~~'''Tumour~~-~~like lesions~~ with T-~~cell predominance'''~~

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- [[HAEM4:Acute Myeloid Leukemia (AML) with Minimal Differentiation|AML with Minimal Differentiation]]

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- [[HAEM4:~~Kikuchi~~-~~Fujimoto disease~~]]

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- [[HAEM4:Acute Myeloid Leukemia (AML) without Maturation|AML without Maturation]]

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- [[HAEM4:~~Autoimmune lymphoproliferative syndrome~~]]

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- [[HAEM4:Acute Myeloid Leukemia (AML) with Maturation|AML with Maturation]]

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- [[HAEM4:~~Indolent T~~-~~lymphoblastic proliferation~~]]

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- [[HAEM4:Acute Myelomonocytic Leukemia]]

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- [[HAEM4:Acute Monoblastic and Monocytic Leukemia]]

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- [[HAEM4:Pure Erythroid Leukemia]]

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- [[HAEM4:Acute Megakaryoblastic Leukemia (AMKL)]]

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- [[HAEM4:Acute Basophilic Leukemia]]

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- [[HAEM4:Acute Panmyelosis with Myelofibrosis]]

−

~~'''Precursor T-cell neoplasms'''~~

+

*[[HAEM4:Myeloid Sarcoma]]

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~~''T-lymphoblastic leukaemia / lymphoma''~~

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- [[HAEM4:~~T-lymphoblastic leukaemia / lymphoma, NOS]]~~

−

~~- [[HAEM4:Early T-precursor lymphoblastic leukaemia / lymphoma~~ ]]

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~~'''Mature T-cell and NK-cell neoplasms'''~~

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*[[HAEM4:Myeloid Proliferations Associated with Down Syndrome]]

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~~''Mature T-cell and NK-cell leukaemias''~~

−

- [[HAEM4:~~T-prolymphocytic leukaemia~~]]

−

~~- [[HAEM4:T-large granular lymphocytic leukaemia]]~~

−

~~- [[HAEM4:NK-large granular lymphocytic leukaemia]]~~

−

~~- [[HAEM4:Adult T-cell leukaemia/lymphoma]]~~

−

~~- [[HAEM4:Sezary syndrome]]~~

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~~- [[HAEM4:Aggressive NK-cell leukaemia]]~~

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~~''Primary cutaneous T-cell lymphoid proliferations and lymphomas''~~

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~~- [[HAEM4:Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder]]~~

−

~~- [[HAEM4:Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder]]~~

−

~~- [[HAEM4:Mycosis fungoides]]~~

−

~~- [[HAEM4:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis]]~~

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~~- [[HAEM4:Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma]]~~

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~~- [[HAEM4:Subcutaneous panniculitis-like T-cell lymphoma]]~~

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~~- [[HAEM4:Primary cutaneous gamma/delta T-cell lymphoma]]~~

−

~~- [[HAEM4:Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma]]~~

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~~- [[HAEM4:Primary cutaneous peripheral T-cell lymphoma, NOS]]~~

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~~''Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas''~~

−

~~- [[HAEM4:Indolent T-cell lymphoma of the gastrointestinal tract]]~~

−

~~- [[HAEM4:Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract]]~~

−

~~- [[HAEM4:Enteropathy-associated T-cell lymphoma]]~~

−

~~- [[HAEM4:Monomorphic epitheliotropic intestinal T-cell lymphoma]]~~

−

~~- [[HAEM4:Intestinal T-cell lymphoma, NOS]]~~

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~~''Hepatosplenic T-cell lymphoma''~~

−

~~- [[HAEM4:Hepatosplenic T-cell lymphoma]]~~

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~~''Anaplastic large cell lymphoma''~~

−

~~- [[HAEM4:ALK-positive anaplastic large cell lymphoma]]~~

−

~~- [[HAEM4:ALK-negative anaplastic large cell lymphoma]]~~

−

~~- [[HAEM4:Breast implant-associated anaplastic large cell lymphoma]]~~

−

~~''Nodal T-follicular helper (TFH) cell lymphoma''~~

−

~~- [[HAEM4:Nodal TFH cell lymphoma, angioimmunoblastic-type]]~~

−

~~- [[HAEM4:Nodal TFH cell lymphoma, follicular-type]]~~

−

~~- [[HAEM4:Nodal TFH cell lymphoma, NOS]]~~

−

~~''Other peripheral T-cell lymphomas''~~

−

~~- [[HAEM4:Peripheral T-cell lymphoma, NOS]]~~

−

~~''EBV-positive NK-cell and T-cell lymphomas''~~

−

~~- [[HAEM4:EBV-positive nodal T- and NK-cell lymphoma]]~~

−

~~- [[HAEM4:Extranodal NK/T-cell lymphoma]]~~

−

~~''EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood''~~

−

~~- [[HAEM4:Severe mosquito bite allergy]]~~

−

~~- [[HAEM4:Hydroa vacciniforme lymphoproliferative disorder]]~~

−

~~- [[HAEM4:Systemic chronic active EBV disease]]~~

−

~~- [[HAEM4:Systemic EBV-positive T-cell lymphoma of childhood]]~~

−

~~==Stroma-derived neoplasms of lymphoid tissues==~~

−

~~'''Mesenchymal dendritic cell neoplasms'''~~

+

- [[HAEM4:Transient Abnormal Myelopoiesis (TAM) Associated with Down Syndrome]]

−

~~''Follicular dendritic cell neoplasms''~~

+

- [[HAEM4:Myeloid Leukemia Associated with Down Syndrome]]

−

- [[HAEM4:~~Follicular dendritic cell sarcoma]]~~

−

~~- [[HAEM4:EBV-positive inflammatory follicular dendritic cell sarcoma~~]]

−

- [[HAEM4:~~Fibroblastic reticular cell tumour~~]]

−

~~'''Myofibroblastic tumours'''~~

+

==Blastic Plasmacytoid Dendritic Cell Neoplasm ([[HAEM4:Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms|Overview Page Link]])==

−

~~''Myofibroblastic tumour''~~

−

- [[HAEM4:~~Intranodal palisaded myofibroblastoma~~]]

−

~~'''Spleen~~-~~specific vascular~~-~~stromal tumours'''~~

+

*[[HAEM4:Blastic Plasmacytoid Dendritic Cell Neoplasm]]

−

''Splenic ~~vascular~~-~~stromal tumours''~~

+

−

- [[HAEM4:~~Littoral~~ cell ~~angioma~~]]

+

==Acute Leukemias of Ambiguous Lineage (MPAL) ([[HAEM4:Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms|Overview Page Link]])==

−

- [[HAEM4:~~Splenic hamartoma~~]]

+

−

- [[HAEM4:~~Sclerosing angiomatoid nodular transformation~~ (~~SANT~~) of ~~spleen~~]]

+

*[[HAEM4:Acute Leukemias of Ambiguous Lineage]]

−

==~~Genetic tumour syndromes~~==

+

−

- [[HAEM4:~~Fanconi anaemia~~]]

+

- [[HAEM4:Acute Undifferentiated Leukemia]]

−

- [[HAEM4:~~Bloom syndrome~~]]

+

- [[HAEM4:Mixed Phenotype Acute Leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR-ABL1]]

−

- [[HAEM4:~~Ataxia~~-~~telangiectasia syndrome~~]]

+

- [[HAEM4:Mixed Phenotype Acute Leukemia (MPAL) with t(v;11q23.3); KMT2A Rearranged]]

−

- [[HAEM4:~~RASopathies~~]]

+

- [[HAEM4:Mixed Phenotype Acute Leukemia (MPAL), B/Myeloid, Not Otherwise Specified]]

+

- [[HAEM4:Mixed Phenotype Acute Leukemia (MPAL), T/Myeloid, Not Otherwise Specified]]

+

- [[HAEM4:Mixed-Phenotype Acute Leukemia, Not Otherwise Specified (NOS), Rare Types]]

+

- [[HAEM4:Acute Leukemias of Ambiguous Lineage, Not Otherwise Specified (NOS)]]

+

==Precursor Lymphoid Neoplasms (B-ALL, T-ALL) ([[HAEM4:Precursor Lymphoid Neoplasms|Overview Page Link]])==

+

*[[HAEM4:B-Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities|B-Lymphoblastic Leukemia/Lymphoma (B-ALL) with Recurrent Genetic Abnormalities]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1|B-ALL with t(9;22)(q34.1;q11.2); BCR-ABL1]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A-Rearranged|B-ALL with t(v;11q23.3); KMT2A-Rearranged]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1|B-ALL with t(12;21)(p13.2;q22.1); ETV6-RUNX1]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma with Hyperdiploidy|B-ALL with Hyperdiploidy]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma with Hypodiploidy|B-ALL with Hypodiploidy]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma with t(5;14)(q31.1;q32.1); IGH/IL3|B-ALL with t(5;14)(q31.1;q32.1); IGH/IL3]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1|B-ALL with t(1;19)(q23;p13.3); TCF3-PBX1]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like|B-ALL, BCR-ABL1-Like]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma with iAMP21|B-ALL with iAMP21]]

+

- [[HAEM4:B-Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified|B-ALL, Not Otherwise Specified]]

+

*[[HAEM4:T-Lymphoblastic Leukemia/Lymphoma|T-Lymphoblastic Leukemia/Lymphoma (T-ALL)]]

+

- [[HAEM4:Early T-Cell Precursor Lymphoblastic Leukemia]]

+

- [[HAEM4:NK-Lymphoblastic Leukemia/Lymphoma]]

+

==Mature B-Cell Neoplasms (CLL, Plasma Cell Neoplasms, Non-Hodgkin B-cell Lymphomas) ([[HAEM4:Mature B-Cell Neoplasms|Overview Page Link]])==

+

*[[HAEM4:Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma]]

+

- [[HAEM4:Monoclonal B-cell Lymphocytosis]]

+

*[[HAEM4:B-cell Prolymphocytic Leukemia]]

+

*[[HAEM4:Splenic Marginal Zone Lymphoma]]

+

*[[HAEM4:Hairy Cell Leukemia]]

+

*[[HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable]]

+

- [[HAEM4:Splenic Diffuse Red Pulp Small B-cell Lymphoma]]

+

- [[HAEM4:Hairy Cell Leukemia Variant]]

+

*[[HAEM4:Lymphoplasmacytic Lymphoma]]

+

- [[HAEM4:Waldenstrom Macroglobulinemia]]

+

*[[HAEM4:IgM Monoclonal Gammopathy of Undetermined Significance]]

+

*[[HAEM4:Heavy Chain Diseases]]

+

- [[HAEM4:Mu Heavy Chain Disease]]

+

- [[HAEM4:Gamma Heavy Chain Disease]]

+

- [[HAEM4:Alpha Heavy Chain Disease]]

+

*[[HAEM4:Plasma Cell Neoplasms]]

+

- [[HAEM4:Non-IgM Monoclonal Gammopathy of Undetermined Signiﬁcance]]

+

- [[HAEM4:Plasma Cell Myeloma]]

+

- [[HAEM4:Plasma Cell Myeloma Variants]]

+

- [[HAEM4:Plasmacytoma]]

+

- [[HAEM4:Monoclonal Immunoglobulin Deposition Diseases]]

+

- [[HAEM4:Primary Amyloidosis]]

+

- [[HAEM4:Light Chain and Heavy Chain Deposition Disease]]

+

- [[HAEM4:Plasma Cell Neoplasms with Associated Paraneoplastic Syndrome]]

+

- [[HAEM4:POEMS Syndrome]]

+

- [[HAEM4:TEMPI Syndrome]]

+

*[[HAEM4:Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)]]

+

*[[HAEM4:Nodal Marginal Zone Lymphoma]]

+

- [[HAEM4:Paediatric Nodal Marginal Zone Lymphoma]]

+

*[[HAEM4:Follicular Lymphoma]]

+

- [[HAEM4:Testicular Follicular Lymphoma]]

+

- [[HAEM4:In Situ Follicular Neoplasia]]

+

- [[HAEM4:Duodenal-Type Follicular Lymphoma]]

+

*[[HAEM4:Paediatric-Type Follicular Lymphoma]]

+

*[[HAEM4:Large B-cell Lymphoma with IRF4 Rearrangement]]

+

*[[HAEM4:Primary Cutaneous Follicle Centre Lymphoma]]

+

*[[HAEM4:Mantle Cell Lymphoma]]

+

- [[HAEM4:Leukemic Non-Nodal Mantle Cell Lymphoma]]

+

- [[HAEM4:In Situ Mantle Cell Neoplasia]]

+

*[[HAEM4:Diffuse Large B-cell Lymphoma, Not Otherwise Specified]]

+

*[[HAEM4:T-cell/Histiocyte-Rich Large B-cell Lymphoma]]

+

*[[HAEM4:Primary Diffuse Large B-cell Lymphoma of the CNS]]

+

*[[HAEM4:Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type]]

+

*[[HAEM4:EBV-Positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified (NOS)]]

+

*[[HAEM4:EBV-Positive Mucocutaneous Ulcer]]

+

*[[HAEM4:Diffuse Large B-cell Lymphoma Associated with Chronic Inflammation]]

+

- [[HAEM4:Fibrin-Associated Diffuse Large B-cell Lymphoma]]

+

*[[HAEM4:Lymphomatoid Granulomatosis]]

+

*[[HAEM4:Primary Mediastinal (Thymic) Large B-cell Lymphoma]]

+

*[[HAEM4:Intravascular Large B-cell Lymphoma]]

+

*[[HAEM4:ALK-Positive Large B-cell Lymphoma]]

+

*[[HAEM4:Plasmablastic Lymphoma]]

+

*[[HAEM4:Primary Effusion Lymphoma]]

+

*[[HAEM4:HHV8-Associated Lymphoproliferative Disorders]]

+

- [[HAEM4:Multicentric Castleman Disease]]

+

- [[HAEM4:HHV8-Positive Diffuse Large B-cell Lymphoma, Not Otherwise Specified (NOS)]]

+

- [[HAEM4:HHV8-Positive Germinotropic Lymphoproliferative Disorder]]

+

*[[HAEM4:Burkitt Lymphoma]]

+

*[[HAEM4:Burkitt-Like Lymphoma with 11q Aberration]]

+

*[[HAEM4:High-Grade B-cell Lymphoma]]

+

- [[HAEM4:High-Grade B-cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements]]

+

- [[HAEM4:High-Grade B-cell Lymphoma, Not Otherwise Specified (NOS)]]

+

*[[HAEM4:B-cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-cell Lymphoma and Classic Hodgkin Lymphoma]]

+

==Mature T- and NK-cell Neoplasms ([[HAEM4:Mature T- and NK-cell Neoplasms|Overview Page Link]])==

+

*[[HAEM4:T-cell Prolymphocytic Leukemia]]

+

*[[HAEM4:T-cell Large Granular Lymphocytic Leukemia]]

+

*[[HAEM4:Chronic Lymphoproliferative Disorder of NK Cells]]

+

*[[HAEM4:Aggressive NK-cell Leukemia]]

+

*[[HAEM4:EBV-Positive T-cell and NK-cell Lymphoproliferative Diseases of Childhood]]

+

- [[HAEM4:Systemic EBV-Positive T-cell Lymphoma of Childhood]]

+

- [[HAEM4:Chronic Active EBV Infection of T- and NK-cell Type, Systemic Form]]

+

- [[HAEM4:Hydroa Vacciniforme-Like Lymphoproliferative Disorder]]

+

- [[HAEM4:Severe Mosquito Bite Allergy]]

+

*[[HAEM4:Adult T-cell Leukemia/Lymphoma]]

+

*[[HAEM4:Extranodal NK/T-cell Lymphoma, Nasal Type]]

+

*[[HAEM4:Intestinal T-cell Lymphoma]]

+

- [[HAEM4:Enteropathy-Associated T-cell Lymphoma]]

+

- [[HAEM4:Monomorphic Epitheliotropic Intestinal T-cell Lymphoma]]

+

- [[HAEM4:Intestinal T-cell Lymphoma, Not Otherwise Specified (NOS)]]

+

- [[HAEM4:Indolent T-cell Lymphoproliferative Disorder of the Gastrointestinal Tract]]

+

*[[HAEM4:Hepatosplenic T-cell Lymphoma]]

+

*[[HAEM4:Subcutaneous Panniculitis-Like T-cell Lymphoma]]

+

*[[HAEM4:Mycosis Fungoides]]

+

*[[HAEM4:Sézary Syndrome]]

+

*[[HAEM4:Primary Cutaneous CD30 Positive T-cell Lymphoproliferative Disorders]]

+

- [[HAEM4:Lymphomatoid Papulosis]]

+

- [[HAEM4:Primary Cutaneous Anaplastic Large Cell Lymphoma]]

+

*[[HAEM4:Primary Cutaneous Peripheral T-cell Lymphomas, Rare Subtypes]]

+

- [[HAEM4:Primary Cutaneous Gamma Delta T-cell Lymphoma]]

+

- [[HAEM4:Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma]]

+

- [[HAEM4:Primary Cutaneous Acral CD8+ T-cell Lymphoma]]

+

- [[HAEM4:Primary Cutaneous CD4+ Small/Medium T-cell Lymphoproliferative Disorder]]

+

*[[HAEM4:Peripheral T-cell Lymphoma, Not Otherwise Specified (NOS)]]

+

*[[HAEM4:Angioimmunoblastic T-cell Lymphoma and Other Nodal Lymphomas of T Follicular Helper Cell Origin]]

+

- [[HAEM4:Angioimmunoblastic T-cell Lymphoma]]

+

- [[HAEM4:Follicular T-cell Lymphoma]]

+

- [[HAEM4:Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype]]

+

*[[HAEM4:Anaplastic Large Cell Lymphoma, ALK-Positive]]

+

*[[HAEM4:Anaplastic Large Cell Lymphoma, ALK-Negative]]

+

*[[HAEM4:Breast Implant-Associated Anaplastic Large Cell Lymphoma]]

+

==Hodgkin Lymphomas ([[HAEM4:Hodgkin Lymphomas|Overview Page Link]])==

+

*[[HAEM4:Nodular Lymphocyte Predominant Hodgkin Lymphoma]]

+

*[[HAEM4:Classic Hodgkin Lymphoma]]

+

- [[HAEM4:Nodular Sclerosis Classic Hodgkin Lymphoma]]

+

- [[HAEM4:Lymphocyte-Rich Classic Hodgkin Lymphoma]]

+

- [[HAEM4:Mixed Cellularity Classic Hodgkin Lymphoma]]

+

- [[HAEM4:Lymphocyte-Depleted Classic Hodgkin Lymphoma]]

+

==Immunodeficiency-Associated Lymphoproliferative Disorders ([[HAEM4:Immunodeficiency-Associated Lymphoproliferative Disorders|Overview Page Link]])==

+

*[[HAEM4:Lymphomas Associated with HIV Infection]]

+

*[[HAEM4:Post-Transplant Lymphoproliferative Disorders]]

+

- [[HAEM4:Non-Destructive Post-Transplant Lymphoproliferative Disorders]]

+

- [[HAEM4:Polymorphic Post-Transplant Lymphoproliferative Disorders]]

+

- [[HAEM4:Monomorphic Post-Transplant Lymphoproliferative Disorders (B- and T/NK-cell Types)]]

+

- [[HAEM4:Monomorphic B-cell PTLD]]

+

- [[HAEM4:Monomorphic T/NK-cell PTLD]]

+

- [[HAEM4:Classical Hodgkin Lymphoma Post-Transplant Lymphoproliferative Disorder]]

+

*[[HAEM4:Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders]]

+

==Histiocytic and Dendritic Cell Neoplasms ([[HAEM4:Histiocytic and Dendritic Cell Neoplasms|Overview Page Link]])==

+

*[[HAEM4:Histiocytic Sarcoma]]

+

*[[HAEM4:Tumors Derived From Langerhans Cells]]

+

- [[HAEM4:Langerhans Cell Histiocytosis]]

+

- [[HAEM4:Langerhans Cell Sarcoma]]

+

*[[HAEM4:Indeterminate Dendritic Cell Tumour]]

+

*[[HAEM4:Interdigitating Dendritic Cell Sarcoma]]

+

*[[HAEM4:Follicular Dendritic Cell Sarcoma]]

+

- [[HAEM4:Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma]]

+

*[[HAEM4:Fibroblastic Reticular Cell Tumor]]

+

*[[HAEM4:Disseminated Juvenile Xanthogranuloma]]

+

*[[HAEM4:Erdheim-Chester Disease]]

+

==Notes==

+

<nowiki>*</nowiki>The hierarchical tumour classification structure displayed on this page is reproduced from the [https://tumourclassification.iarc.who.int/welcome/ WHO Classification of Tumours] with permission from the copyright holder, ©International Agency for Research on Cancer.

Bailey.Glen

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HAEM4:Table of Contents (view source)

Revision as of 16:24, 3 November 2023