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CNS5:Diffuse hemispheric glioma, H3 G34-mutant (view source)
Revision as of 08:03, 2 May 2023
, 08:03, 2 May 2023→NPrimary Author(s)*
==NPrimary Author(s)*==
==Primary Author(s)*==
Xiaolin Hu, PhD, Sema4 OpCo Inc.
Xiaolin Hu, PhD, Sema4 OpCo Inc.
==Gene Mutations (SNV/INDEL/Methylation)==
==Gene Mutations (SNV/INDEL/Methylation)==
<br />
{| class="wikitable sortable"
{| class="wikitable sortable"
!Notes
!Notes
|-
|-
|H3F3A p.G35R/V
|''H3-3A'' p.G35R/V
|chromosome modification
|chromosome modification
|p.G35R 94%
|p.G35R 94%
|
|
|-
|-
|MGMT
|''MGMT''
|promoter methylation
|promoter methylation
|70%-74% of G34-DHG <ref name=":1" /><ref name=":4" />
|70%-74% of G34-DHG <ref name=":1" /><ref name=":4" />
*DNA methylation and gene expression profiling can be used to differentiate G34-DHG with other glioma subgroups.
*DNA methylation and gene expression profiling can be used to differentiate G34-DHG with other glioma subgroups.
*''MGMT'' promoter methylation can be assessed by methylation specific polymerase chain reaction analysis (bisulfite treated DNA undergoes real-time PCR)<br />
*''MGMT'' promoter methylation can be assessed by methylation specific polymerase chain reaction analysis (bisulfite treated DNA undergoes real-time PCR)<br />
==References==
==References==