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{{Under Construction}}
See '''[https://ccga.io/index.php/Author_Instructions ''Author Instructions'']''' and '''[https://ccga.io/index.php/How_to_Curate_a_Gene_Page ''How to Curate a Gene Page'']'''
== Genes Involved ==
==Primary Author(s)*==
Linda B. Baughn, PhD, Mayo Clinic
__TOC__
==Synonyms==
Put your text here
EXAMPLE: Tumor protein p53, 'LFS1, p53, BCC7, TRP53
== Clinical Significance ==
==Genomic Location==
'''Cytoband:''' Put your text here. EXAMPLE: 17p13.1
'''Genomic Coordinates:'''
Put your text here
EXAMPLE: chr17:7,571,720-7,590,868 [hg19]
EXAMPLE: chr17:7,668,402-7,687,538 [hg38]
== Links ==
==Cancer Category/Type==
Put your text here
== References ==
==Gene Overview==
Mullighan, Charles G., et al. "Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia." New England Journal of Medicine 360.5 (2009): 470-480.
Deletion of IKZF1 is a predictor of poor outcome and high risk of relapse in pediatric acute lymphoblastic leukemia.<ref>{{Cite journal|last=Mullighan|first=Charles G.|last2=Su|first2=Xiaoping|last3=Zhang|first3=Jinghui|last4=Radtke|first4=Ina|last5=Phillips|first5=Letha A.A.|last6=Miller|first6=Christopher B.|last7=Ma|first7=Jing|last8=Liu|first8=Wei|last9=Cheng|first9=Cheng|date=2009-01-29|title=Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674612/|journal=The New England journal of medicine|volume=360|issue=5|pages=470–480|doi=10.1056/NEJMoa0808253|issn=0028-4793|pmc=2674612|pmid=19129520}}</ref>
==Common Alteration Types==
Put your text here and fill in the table with an X where applicable
{| class="wikitable sortable"
|-
!Copy Number Loss!!Copy Number Gain!!LOH!!Loss-of-Function Mutation!!Gain-of-Function Mutation!!Translocation/Fusion
|-
|EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X
|}
==Internal Pages==
Put your links here (use "Link" icon at top of page)
==External Links==
Put your text here - Include as applicable links to:
1) Atlas of Genetics and Cytogenetics in Oncology and Haematology,
2) COSMIC,
3) CIViC,
4) St. Jude ProteinPaint,
5) Precision Medicine Knowledgebase (Weill Cornell),
6) Cancer Index,
7) OncoKB,
8) NCBI Gene
9) My Cancer Genome,
10) UniProt,
11) Pfam,
12) GeneCards,
13) OMIM
14) LOVD(3) - Leiden Open Variation Database
15) TICdb - database of Translocation breakpoints In Cancer
16) GeneReviews, and
17) Any gene-specific databases.
EXAMPLES (these may be filled in already)
'''[http://atlasgeneticsoncology.org/Genes/P53ID88.html ''TP53'' by Atlas of Genetics and Cytogenetics in Oncology and Haematology]''' - detailed gene information
'''[https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TP53 ''TP53'' by COSMIC]''' - sequence information, expression, catalogue of mutations
'''[https://civicdb.org/events/genes/45/summary/variants/1300/summary ''TP53'' by CIViC]''' - general knowledge and evidence-based variant specific information
'''[http://p53.iarc.fr/ ''TP53'' by IARC]''' - ''TP53'' database with reference sequences and mutational landscape
'''[https://pecan.stjude.cloud/proteinpaint/tp53 ''TP53'' by St. Jude ProteinPaint]''' mutational landscape and matched expression data.
'''[https://pmkb.weill.cornell.edu/search?utf8=%E2%9C%93&search=tp53 ''TP53'' by Precision Medicine Knowledgebase (Weill Cornell)]''' - manually vetted interpretations of variants and CNVs
'''[http://www.cancerindex.org/geneweb/TP53.htm ''TP53'' by Cancer Index]''' - gene, pathway, publication information matched to cancer type
'''[http://oncokb.org/#/gene/TP53 ''TP53'' by OncoKB]''' - mutational landscape, mutation effect, variant classification
'''[https://www.ncbi.nlm.nih.gov/gene/2122 ''MECOM'' by NCBI Gene]''' - brief gene overview
'''[https://www.mycancergenome.org/content/gene/tp53/ ''TP53'' by My Cancer Genome]''' - brief gene overview
'''[http://www.uniprot.org/uniprot/P04637 ''TP53'' by UniProt]''' - protein and molecular structure and function
'''[https://pfam.xfam.org/family/p53 ''TP53'' by Pfam]''' - gene and protein structure and function information
'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=tp53 ''TP53'' by GeneCards]''' - general gene information and summaries
'''[http://www.omim.org/entry/165215 ''MECOM'' by OMIM]''' - compendium of human genes and genetic phenotypes
'''[https://databases.lovd.nl/shared/genes/MECOM ''MECOM'' by LOVD(3)]''' - Leiden Open Variation Database
'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=MECOM ''MECOM'' by TICdb]''' - database of Translocation breakpoints In Cancer
'''[https://www.ncbi.nlm.nih.gov/books/NBK1311/ GeneReviews]''' - information on Li Fraumeni Syndrome
==References==
(use "Cite" icon at top of page)
<references />
===EXAMPLE Book===
#Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p129-171.
===EXAMPLE Internet Resource===
#author name(s). Date (if possible). page title, website title, web address, and date accessed.
#Cingam, S. R. and Koshy, N.V. (2017). Cancer, Leukemia, Promyelocytic, Acute (APL, APML). https://www.ncbi.nlm.nih.gov/books/NBK459352/ Accessed August 3, 2018.
==Notes==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.